TOP TEN perturbations for 38474_at (Homo sapiens)

Organism: Homo sapiens
Gene: 38474_at
Selected probe(set): 1553972_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38474_at (1553972_a_at) across 6674 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):-3.9859324
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2.

lung cancer study 1 (PDX; pseudosarcomatous carcinoma; primary) / lung cancer study 1 (PDX; non-small cell carcinoma; primary)

Relative Expression (log2-ratio):-3.815073
Number of Samples:4 / 2
Experimental lung cancer study 1 (PDX; pseudosarcomatous carcinoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary pseudosarcomatous carcinoma of the lung (subcutaneously implanted).
Control lung cancer study 1 (PDX; non-small cell carcinoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary non-small cell carcinoma of the lung (subcutaneously implanted).

expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (carcinoma, NOS; metastatic)

Relative Expression (log2-ratio):-3.7077904
Number of Samples:2 / 5
Experimental expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic)
Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary.
Control expO ovary cancer study 1 (carcinoma, NOS; metastatic)
Metastatic tumor tissue samples obtained from patients with primary carcinoma (NOS) of the ovary.

hepatoblastoma study 1 (crowded fetal) / normal liver tissue

Relative Expression (log2-ratio):-3.6241674
Number of Samples:3 / 5
Experimental hepatoblastoma study 1 (crowded fetal)
Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); crowded fetal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; lung)

Relative Expression (log2-ratio):3.3779716
Number of Samples:2 / 5
Experimental colorectal cancer study 43 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma.
Control colorectal cancer study 43 (metastase; lung)
Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma.

hepatoblastoma study 1 (epithelial mixed) / normal liver tissue

Relative Expression (log2-ratio):-3.3338833
Number of Samples:12 / 5
Experimental hepatoblastoma study 1 (epithelial mixed)
Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); epithelial mixed subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

ovarian tumor study 28 (endometrioid carcinoma) / ovarian tumor study 28 (adenocarcinoma)

Relative Expression (log2-ratio):-3.3125982
Number of Samples:6 / 3
Experimental ovarian tumor study 28 (endometrioid carcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with endometrioid carcinoma.
Control ovarian tumor study 28 (adenocarcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with adenocarcinoma.

expO endometrial cancer study 1 (papillary serous cystadenocarcinoma; metastatic) / expO endometrial cancer study 1 (endometrioid carcinoma; metastatic)

Relative Expression (log2-ratio):3.229662
Number of Samples:2 / 20
Experimental expO endometrial cancer study 1 (papillary serous cystadenocarcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary papillary serous cystadenocarcinoma of the endometrium.
Control expO endometrial cancer study 1 (endometrioid carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the endometrium.

expO ovary cancer study 1 (endometrioid and clear cell adenocarcinoma; primary) / expO ovary cancer study 1 (adenocarcinoma with mixed subtypes; primary)

Relative Expression (log2-ratio):-3.089655
Number of Samples:2 / 4
Experimental expO ovary cancer study 1 (endometrioid and clear cell adenocarcinoma; primary)
Primary tumor tissue samples obtained from the ovary of patients with endometrioid and clear cell adenocarcinoma.
Control expO ovary cancer study 1 (adenocarcinoma with mixed subtypes; primary)
Primary tumor tissue samples obtained from the ovary of patients with adenocarcinoma with mixed subtypes.

hepatoblastoma study 1 (mixed epithelial and mesenchymal) / normal liver tissue

Relative Expression (log2-ratio):-3.085144
Number of Samples:4 / 5
Experimental hepatoblastoma study 1 (mixed epithelial and mesenchymal)
Liver tumor tissue samples from children with hepatoblastoma (mesenchymal type (MEM-HB); mixed epithelial and mesenchymal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

Organism: Homo sapiens
Gene: 38474_at
Selected probe(set): 1553972_a_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38474_at (1553972_a_at) across 6674 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):-3.9859324
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2.

lung cancer study 1 (PDX; pseudosarcomatous carcinoma; primary) / lung cancer study 1 (PDX; non-small cell carcinoma; primary)

Relative Expression (log2-ratio):-3.815073
Number of Samples:4 / 2
Experimental lung cancer study 1 (PDX; pseudosarcomatous carcinoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary pseudosarcomatous carcinoma of the lung (subcutaneously implanted).
Control lung cancer study 1 (PDX; non-small cell carcinoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary non-small cell carcinoma of the lung (subcutaneously implanted).

expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (carcinoma, NOS; metastatic)

Relative Expression (log2-ratio):-3.7077904
Number of Samples:2 / 5
Experimental expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic)
Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary.
Control expO ovary cancer study 1 (carcinoma, NOS; metastatic)
Metastatic tumor tissue samples obtained from patients with primary carcinoma (NOS) of the ovary.

hepatoblastoma study 1 (crowded fetal) / normal liver tissue

Relative Expression (log2-ratio):-3.6241674
Number of Samples:3 / 5
Experimental hepatoblastoma study 1 (crowded fetal)
Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); crowded fetal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; lung)

Relative Expression (log2-ratio):3.3779716
Number of Samples:2 / 5
Experimental colorectal cancer study 43 (metastase; brain)
Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma.
Control colorectal cancer study 43 (metastase; lung)
Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma.

hepatoblastoma study 1 (epithelial mixed) / normal liver tissue

Relative Expression (log2-ratio):-3.3338833
Number of Samples:12 / 5
Experimental hepatoblastoma study 1 (epithelial mixed)
Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); epithelial mixed subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.

ovarian tumor study 28 (endometrioid carcinoma) / ovarian tumor study 28 (adenocarcinoma)

Relative Expression (log2-ratio):-3.3125982
Number of Samples:6 / 3
Experimental ovarian tumor study 28 (endometrioid carcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with endometrioid carcinoma.
Control ovarian tumor study 28 (adenocarcinoma)
Primary tumor tissue sample obtained from the ovary of female patients with adenocarcinoma.

expO endometrial cancer study 1 (papillary serous cystadenocarcinoma; metastatic) / expO endometrial cancer study 1 (endometrioid carcinoma; metastatic)

Relative Expression (log2-ratio):3.229662
Number of Samples:2 / 20
Experimental expO endometrial cancer study 1 (papillary serous cystadenocarcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary papillary serous cystadenocarcinoma of the endometrium.
Control expO endometrial cancer study 1 (endometrioid carcinoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the endometrium.

expO ovary cancer study 1 (endometrioid and clear cell adenocarcinoma; primary) / expO ovary cancer study 1 (adenocarcinoma with mixed subtypes; primary)

Relative Expression (log2-ratio):-3.089655
Number of Samples:2 / 4
Experimental expO ovary cancer study 1 (endometrioid and clear cell adenocarcinoma; primary)
Primary tumor tissue samples obtained from the ovary of patients with endometrioid and clear cell adenocarcinoma.
Control expO ovary cancer study 1 (adenocarcinoma with mixed subtypes; primary)
Primary tumor tissue samples obtained from the ovary of patients with adenocarcinoma with mixed subtypes.

hepatoblastoma study 1 (mixed epithelial and mesenchymal) / normal liver tissue

Relative Expression (log2-ratio):-3.085144
Number of Samples:4 / 5
Experimental hepatoblastoma study 1 (mixed epithelial and mesenchymal)
Liver tumor tissue samples from children with hepatoblastoma (mesenchymal type (MEM-HB); mixed epithelial and mesenchymal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group.
Control normal liver tissue
Normal liver tissue samples.