TOP TEN perturbations for 38517_at (Homo sapiens)

Organism: Homo sapiens
Gene: 38517_at
Selected probe(set): 203882_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38517_at (203882_at) across 6674 perturbations tested by GENEVESTIGATOR:

glioma study 16 (LN-319) / normal astrocyte sample

Relative Expression (log2-ratio):4.7397556
Number of Samples:2 / 3
Experimental glioma study 16 (LN-319)
Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

p63 depletion study 1 (shRNA) / empty vector transduced ME180 cell sample

Relative Expression (log2-ratio):4.559147
Number of Samples:3 / 3
Experimental p63 depletion study 1 (shRNA)
ME180 cells were transduced with lentiviral supernatant containing pLL p63shRNA, and harvested ~65 hours later.
Control empty vector transduced ME180 cell sample
ME180 cells were transduced with lentiviral supernatant containing empty vector, and harvested ~65 hours later.

interferon-alpha-A/D study 2 (early) / untreated BE(2)-C cell sample (immature)

Relative Expression (log2-ratio):3.9605494
Number of Samples:3 / 3
Experimental interferon-alpha-A/D study 2 (early)
Undifferentiated, cultured BE(2)-C cells were incubated with universal type I IFN (IFNa-A/D) for 6 hours before samples were taken. ATC code:---
Control untreated BE(2)-C cell sample (immature)
Undifferentiated, cultured BE(2)-C neuroblastoma cell samples.

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):3.649993
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

interferon-alpha-A/D study 2 (late) / untreated BE(2)-C cell sample (immature)

Relative Expression (log2-ratio):3.5987225
Number of Samples:3 / 3
Experimental interferon-alpha-A/D study 2 (late)
Undifferentiated, cultured BE(2)-C cells were incubated with universal type I IFN (IFNa-A/D) for 12 hours before samples were taken. ATC code:---
Control untreated BE(2)-C cell sample (immature)
Undifferentiated, cultured BE(2)-C neuroblastoma cell samples.

interferon-alpha-A/D study 1 (early) / untreated BE(2)-C cell sample (mature)

Relative Expression (log2-ratio):3.2365417
Number of Samples:3 / 3
Experimental interferon-alpha-A/D study 1 (early)
Cultured BE(2)-C cells were differentiated with 10 uM all-trans retinoic acid (RA) for 3 weeks into cells with mature neuron cell characteristics and incubated with universal type I IFN (IFN-alpha-A/D) for 6 hours before samples were taken. ATC code:---
Control untreated BE(2)-C cell sample (mature)
Differentiated, cultured BE(2)-C neuroblastoma cells. Cells were differentiated with 10 uM all-trans retinoic acid (RA) for 3 weeks into cells with mature neuron cell characteristics before samples were taken.

glioma study 16 (BS-149) / normal astrocyte sample

Relative Expression (log2-ratio):3.215704
Number of Samples:2 / 3
Experimental glioma study 16 (BS-149)
Human glioma cell line BS149 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

IFN-a2b study 2 / untreated mouse-derived ovarian cancer cell (sidep.) sample

Relative Expression (log2-ratio):3.200674
Number of Samples:2 / 2
Experimental IFN-a2b study 2
Side population subset of ovarian cancer cells derived from the malignant effusion developed in mice injected with cells obtained from ascitic fluid of ovarian cancer bearing-patients. Cells were treated with 1000 IU/ml IFN-alpha2b for 5 hours.
Control untreated mouse-derived ovarian cancer cell (sidep.) sample
Side population subset of ovarian cancer cells derived from the malignant effusion developed in mice injected with cells obtained from ascitic fluid of ovarian cancer bearing-patients. Cells were untreated.

expO connective/soft tissue cancer study 1 (myxoid liposarcoma; metastatic) / expO connective/soft tissue cancer study 1 (fibrous histiocytoma, malignant; metastatic)

Relative Expression (log2-ratio):-2.87387
Number of Samples:2 / 5
Experimental expO connective/soft tissue cancer study 1 (myxoid liposarcoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary myxoid liposarcoma of the connective and soft tissue.
Control expO connective/soft tissue cancer study 1 (fibrous histiocytoma, malignant; metastatic)
Metastatic tumor tissue samples obtained from patients with primary malignant fibrous histiocytoma of the connective and soft tissue.

MCF-7.5C / MCF-7

Relative Expression (log2-ratio):2.8238
Number of Samples:3 / 4
Experimental MCF-7.5C
Human metastatic cancer cell line derived from the pleural effusion of a patient with adenocarcinoma of the breast. Long-term estrogen deprived breast cancer cells, which are resistant to estrogen-deprivation and therefore show an aromatase inhibitor resistantance. Parental cell line:: MCF-7 Synonyms:MCF-7 clone 5C; 5C; MCF-7:5C Cellosaurus code:
Control MCF-7
Human metastatic cancer cell line derived from the pleural effusion of a patient (69 years old, caucasian) with adenocarcinoma of the breast. Synonyms:MCF 7; MCF.7; MCF7; Michigan Cancer Foundation 7; ssMCF7; MCF7/WT; IBMF-7; MCF7-CTRL Cellosaurus code:

Organism: Homo sapiens
Gene: 38517_at
Selected probe(set): 203882_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38517_at (203882_at) across 6674 perturbations tested by GENEVESTIGATOR:

glioma study 16 (LN-319) / normal astrocyte sample

Relative Expression (log2-ratio):4.7397556
Number of Samples:2 / 3
Experimental glioma study 16 (LN-319)
Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

p63 depletion study 1 (shRNA) / empty vector transduced ME180 cell sample

Relative Expression (log2-ratio):4.559147
Number of Samples:3 / 3
Experimental p63 depletion study 1 (shRNA)
ME180 cells were transduced with lentiviral supernatant containing pLL p63shRNA, and harvested ~65 hours later.
Control empty vector transduced ME180 cell sample
ME180 cells were transduced with lentiviral supernatant containing empty vector, and harvested ~65 hours later.

interferon-alpha-A/D study 2 (early) / untreated BE(2)-C cell sample (immature)

Relative Expression (log2-ratio):3.9605494
Number of Samples:3 / 3
Experimental interferon-alpha-A/D study 2 (early)
Undifferentiated, cultured BE(2)-C cells were incubated with universal type I IFN (IFNa-A/D) for 6 hours before samples were taken. ATC code:---
Control untreated BE(2)-C cell sample (immature)
Undifferentiated, cultured BE(2)-C neuroblastoma cell samples.

glioma study 16 (LN-215) / normal astrocyte sample

Relative Expression (log2-ratio):3.649993
Number of Samples:2 / 3
Experimental glioma study 16 (LN-215)
Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

interferon-alpha-A/D study 2 (late) / untreated BE(2)-C cell sample (immature)

Relative Expression (log2-ratio):3.5987225
Number of Samples:3 / 3
Experimental interferon-alpha-A/D study 2 (late)
Undifferentiated, cultured BE(2)-C cells were incubated with universal type I IFN (IFNa-A/D) for 12 hours before samples were taken. ATC code:---
Control untreated BE(2)-C cell sample (immature)
Undifferentiated, cultured BE(2)-C neuroblastoma cell samples.

interferon-alpha-A/D study 1 (early) / untreated BE(2)-C cell sample (mature)

Relative Expression (log2-ratio):3.2365417
Number of Samples:3 / 3
Experimental interferon-alpha-A/D study 1 (early)
Cultured BE(2)-C cells were differentiated with 10 uM all-trans retinoic acid (RA) for 3 weeks into cells with mature neuron cell characteristics and incubated with universal type I IFN (IFN-alpha-A/D) for 6 hours before samples were taken. ATC code:---
Control untreated BE(2)-C cell sample (mature)
Differentiated, cultured BE(2)-C neuroblastoma cells. Cells were differentiated with 10 uM all-trans retinoic acid (RA) for 3 weeks into cells with mature neuron cell characteristics before samples were taken.

glioma study 16 (BS-149) / normal astrocyte sample

Relative Expression (log2-ratio):3.215704
Number of Samples:2 / 3
Experimental glioma study 16 (BS-149)
Human glioma cell line BS149 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

IFN-a2b study 2 / untreated mouse-derived ovarian cancer cell (sidep.) sample

Relative Expression (log2-ratio):3.200674
Number of Samples:2 / 2
Experimental IFN-a2b study 2
Side population subset of ovarian cancer cells derived from the malignant effusion developed in mice injected with cells obtained from ascitic fluid of ovarian cancer bearing-patients. Cells were treated with 1000 IU/ml IFN-alpha2b for 5 hours.
Control untreated mouse-derived ovarian cancer cell (sidep.) sample
Side population subset of ovarian cancer cells derived from the malignant effusion developed in mice injected with cells obtained from ascitic fluid of ovarian cancer bearing-patients. Cells were untreated.

expO connective/soft tissue cancer study 1 (myxoid liposarcoma; metastatic) / expO connective/soft tissue cancer study 1 (fibrous histiocytoma, malignant; metastatic)

Relative Expression (log2-ratio):-2.87387
Number of Samples:2 / 5
Experimental expO connective/soft tissue cancer study 1 (myxoid liposarcoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary myxoid liposarcoma of the connective and soft tissue.
Control expO connective/soft tissue cancer study 1 (fibrous histiocytoma, malignant; metastatic)
Metastatic tumor tissue samples obtained from patients with primary malignant fibrous histiocytoma of the connective and soft tissue.

MCF-7.5C / MCF-7

Relative Expression (log2-ratio):2.8238
Number of Samples:3 / 4
Experimental MCF-7.5C
Human metastatic cancer cell line derived from the pleural effusion of a patient with adenocarcinoma of the breast. Long-term estrogen deprived breast cancer cells, which are resistant to estrogen-deprivation and therefore show an aromatase inhibitor resistantance. Parental cell line:: MCF-7 Synonyms:MCF-7 clone 5C; 5C; MCF-7:5C Cellosaurus code:
Control MCF-7
Human metastatic cancer cell line derived from the pleural effusion of a patient (69 years old, caucasian) with adenocarcinoma of the breast. Synonyms:MCF 7; MCF.7; MCF7; Michigan Cancer Foundation 7; ssMCF7; MCF7/WT; IBMF-7; MCF7-CTRL Cellosaurus code: