TOP TEN perturbations for 38517_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38517_at
Selected probe(set): 203882_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38517_at (203882_at) across 6674 perturbations tested by GENEVESTIGATOR:
glioma study 16 (LN-319) / normal astrocyte sample
Relative Expression (log2-ratio):4.7397556Number of Samples:2 / 3
| Experimental | glioma study 16 (LN-319) |
| Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2. | |
| Control | normal astrocyte sample |
| Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
p63 depletion study 1 (shRNA) / empty vector transduced ME180 cell sample
Relative Expression (log2-ratio):4.559147Number of Samples:3 / 3
| Experimental | p63 depletion study 1 (shRNA) |
| ME180 cells were transduced with lentiviral supernatant containing pLL p63shRNA, and harvested ~65 hours later. | |
| Control | empty vector transduced ME180 cell sample |
| ME180 cells were transduced with lentiviral supernatant containing empty vector, and harvested ~65 hours later. |
interferon-alpha-A/D study 2 (early) / untreated BE(2)-C cell sample (immature)
Relative Expression (log2-ratio):3.9605494Number of Samples:3 / 3
| Experimental | interferon-alpha-A/D study 2 (early) |
| Undifferentiated, cultured BE(2)-C cells were incubated with universal type I IFN (IFNa-A/D) for 6 hours before samples were taken. ATC code:--- | |
| Control | untreated BE(2)-C cell sample (immature) |
| Undifferentiated, cultured BE(2)-C neuroblastoma cell samples. |
glioma study 16 (LN-215) / normal astrocyte sample
Relative Expression (log2-ratio):3.649993Number of Samples:2 / 3
| Experimental | glioma study 16 (LN-215) |
| Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2. | |
| Control | normal astrocyte sample |
| Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
interferon-alpha-A/D study 2 (late) / untreated BE(2)-C cell sample (immature)
Relative Expression (log2-ratio):3.5987225Number of Samples:3 / 3
| Experimental | interferon-alpha-A/D study 2 (late) |
| Undifferentiated, cultured BE(2)-C cells were incubated with universal type I IFN (IFNa-A/D) for 12 hours before samples were taken. ATC code:--- | |
| Control | untreated BE(2)-C cell sample (immature) |
| Undifferentiated, cultured BE(2)-C neuroblastoma cell samples. |
interferon-alpha-A/D study 1 (early) / untreated BE(2)-C cell sample (mature)
Relative Expression (log2-ratio):3.2365417Number of Samples:3 / 3
| Experimental | interferon-alpha-A/D study 1 (early) |
| Cultured BE(2)-C cells were differentiated with 10 uM all-trans retinoic acid (RA) for 3 weeks into cells with mature neuron cell characteristics and incubated with universal type I IFN (IFN-alpha-A/D) for 6 hours before samples were taken. ATC code:--- | |
| Control | untreated BE(2)-C cell sample (mature) |
| Differentiated, cultured BE(2)-C neuroblastoma cells. Cells were differentiated with 10 uM all-trans retinoic acid (RA) for 3 weeks into cells with mature neuron cell characteristics before samples were taken. |
glioma study 16 (BS-149) / normal astrocyte sample
Relative Expression (log2-ratio):3.215704Number of Samples:2 / 3
| Experimental | glioma study 16 (BS-149) |
| Human glioma cell line BS149 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2. | |
| Control | normal astrocyte sample |
| Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
IFN-a2b study 2 / untreated mouse-derived ovarian cancer cell (sidep.) sample
Relative Expression (log2-ratio):3.200674Number of Samples:2 / 2
| Experimental | IFN-a2b study 2 |
| Side population subset of ovarian cancer cells derived from the malignant effusion developed in mice injected with cells obtained from ascitic fluid of ovarian cancer bearing-patients. Cells were treated with 1000 IU/ml IFN-alpha2b for 5 hours. | |
| Control | untreated mouse-derived ovarian cancer cell (sidep.) sample |
| Side population subset of ovarian cancer cells derived from the malignant effusion developed in mice injected with cells obtained from ascitic fluid of ovarian cancer bearing-patients. Cells were untreated. |
expO connective/soft tissue cancer study 1 (myxoid liposarcoma; metastatic) / expO connective/soft tissue cancer study 1 (fibrous histiocytoma, malignant; metastatic)
Relative Expression (log2-ratio):-2.87387Number of Samples:2 / 5
| Experimental | expO connective/soft tissue cancer study 1 (myxoid liposarcoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary myxoid liposarcoma of the connective and soft tissue. | |
| Control | expO connective/soft tissue cancer study 1 (fibrous histiocytoma, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary malignant fibrous histiocytoma of the connective and soft tissue. |
MCF-7.5C / MCF-7
Relative Expression (log2-ratio):2.8238Number of Samples:3 / 4
| Experimental | MCF-7.5C |
| Human metastatic cancer cell line derived from the pleural effusion of a patient with adenocarcinoma of the breast. Long-term estrogen deprived breast cancer cells, which are resistant to estrogen-deprivation and therefore show an aromatase inhibitor resistantance. Parental cell line:: MCF-7 Synonyms:MCF-7 clone 5C; 5C; MCF-7:5C Cellosaurus code: | |
| Control | MCF-7 |
| Human metastatic cancer cell line derived from the pleural effusion of a patient (69 years old, caucasian) with adenocarcinoma of the breast. Synonyms:MCF 7; MCF.7; MCF7; Michigan Cancer Foundation 7; ssMCF7; MCF7/WT; IBMF-7; MCF7-CTRL Cellosaurus code: |
Organism: Homo sapiens
Gene: 38517_at
Selected probe(set): 203882_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38517_at (203882_at) across 6674 perturbations tested by GENEVESTIGATOR:
glioma study 16 (LN-319) / normal astrocyte sample
Relative Expression (log2-ratio):4.7397556Number of Samples:2 / 3
| Experimental | glioma study 16 (LN-319) |
| Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2. | |
| Control | normal astrocyte sample |
| Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
p63 depletion study 1 (shRNA) / empty vector transduced ME180 cell sample
Relative Expression (log2-ratio):4.559147Number of Samples:3 / 3
| Experimental | p63 depletion study 1 (shRNA) |
| ME180 cells were transduced with lentiviral supernatant containing pLL p63shRNA, and harvested ~65 hours later. | |
| Control | empty vector transduced ME180 cell sample |
| ME180 cells were transduced with lentiviral supernatant containing empty vector, and harvested ~65 hours later. |
interferon-alpha-A/D study 2 (early) / untreated BE(2)-C cell sample (immature)
Relative Expression (log2-ratio):3.9605494Number of Samples:3 / 3
| Experimental | interferon-alpha-A/D study 2 (early) |
| Undifferentiated, cultured BE(2)-C cells were incubated with universal type I IFN (IFNa-A/D) for 6 hours before samples were taken. ATC code:--- | |
| Control | untreated BE(2)-C cell sample (immature) |
| Undifferentiated, cultured BE(2)-C neuroblastoma cell samples. |
glioma study 16 (LN-215) / normal astrocyte sample
Relative Expression (log2-ratio):3.649993Number of Samples:2 / 3
| Experimental | glioma study 16 (LN-215) |
| Human glioma cell line LN215 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2. | |
| Control | normal astrocyte sample |
| Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
interferon-alpha-A/D study 2 (late) / untreated BE(2)-C cell sample (immature)
Relative Expression (log2-ratio):3.5987225Number of Samples:3 / 3
| Experimental | interferon-alpha-A/D study 2 (late) |
| Undifferentiated, cultured BE(2)-C cells were incubated with universal type I IFN (IFNa-A/D) for 12 hours before samples were taken. ATC code:--- | |
| Control | untreated BE(2)-C cell sample (immature) |
| Undifferentiated, cultured BE(2)-C neuroblastoma cell samples. |
interferon-alpha-A/D study 1 (early) / untreated BE(2)-C cell sample (mature)
Relative Expression (log2-ratio):3.2365417Number of Samples:3 / 3
| Experimental | interferon-alpha-A/D study 1 (early) |
| Cultured BE(2)-C cells were differentiated with 10 uM all-trans retinoic acid (RA) for 3 weeks into cells with mature neuron cell characteristics and incubated with universal type I IFN (IFN-alpha-A/D) for 6 hours before samples were taken. ATC code:--- | |
| Control | untreated BE(2)-C cell sample (mature) |
| Differentiated, cultured BE(2)-C neuroblastoma cells. Cells were differentiated with 10 uM all-trans retinoic acid (RA) for 3 weeks into cells with mature neuron cell characteristics before samples were taken. |
glioma study 16 (BS-149) / normal astrocyte sample
Relative Expression (log2-ratio):3.215704Number of Samples:2 / 3
| Experimental | glioma study 16 (BS-149) |
| Human glioma cell line BS149 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2. | |
| Control | normal astrocyte sample |
| Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
IFN-a2b study 2 / untreated mouse-derived ovarian cancer cell (sidep.) sample
Relative Expression (log2-ratio):3.200674Number of Samples:2 / 2
| Experimental | IFN-a2b study 2 |
| Side population subset of ovarian cancer cells derived from the malignant effusion developed in mice injected with cells obtained from ascitic fluid of ovarian cancer bearing-patients. Cells were treated with 1000 IU/ml IFN-alpha2b for 5 hours. | |
| Control | untreated mouse-derived ovarian cancer cell (sidep.) sample |
| Side population subset of ovarian cancer cells derived from the malignant effusion developed in mice injected with cells obtained from ascitic fluid of ovarian cancer bearing-patients. Cells were untreated. |
expO connective/soft tissue cancer study 1 (myxoid liposarcoma; metastatic) / expO connective/soft tissue cancer study 1 (fibrous histiocytoma, malignant; metastatic)
Relative Expression (log2-ratio):-2.87387Number of Samples:2 / 5
| Experimental | expO connective/soft tissue cancer study 1 (myxoid liposarcoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary myxoid liposarcoma of the connective and soft tissue. | |
| Control | expO connective/soft tissue cancer study 1 (fibrous histiocytoma, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary malignant fibrous histiocytoma of the connective and soft tissue. |
MCF-7.5C / MCF-7
Relative Expression (log2-ratio):2.8238Number of Samples:3 / 4
| Experimental | MCF-7.5C |
| Human metastatic cancer cell line derived from the pleural effusion of a patient with adenocarcinoma of the breast. Long-term estrogen deprived breast cancer cells, which are resistant to estrogen-deprivation and therefore show an aromatase inhibitor resistantance. Parental cell line:: MCF-7 Synonyms:MCF-7 clone 5C; 5C; MCF-7:5C Cellosaurus code: | |
| Control | MCF-7 |
| Human metastatic cancer cell line derived from the pleural effusion of a patient (69 years old, caucasian) with adenocarcinoma of the breast. Synonyms:MCF 7; MCF.7; MCF7; Michigan Cancer Foundation 7; ssMCF7; MCF7/WT; IBMF-7; MCF7-CTRL Cellosaurus code: |