TOP TEN perturbations for 38519_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38519_at
Selected probe(set): 206340_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38519_at (206340_at) across 6674 perturbations tested by GENEVESTIGATOR:
colorectal cancer study 4 (recurring) / adjacent colon tissue (recurring)
Relative Expression (log2-ratio):-5.0305834Number of Samples:24 / 3
Experimental | colorectal cancer study 4 (recurring) |
LCM-tumor tissue samples of patients who received resection after diagnosis of primary colorectal cancer. Patients developed metastatic recurrence during follow-up after surgery. | |
Control | adjacent colon tissue (recurring) |
Histologically normal colon tissue samples from patients with primary colorectal cancer collected after resection. Tissue was further extracted using laser-capture microdissection (LCM). With metastatic recurrence after resection during follow-up. |
renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; metastatic) / renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; primary)
Relative Expression (log2-ratio):-3.997013Number of Samples:2 / 18
Experimental | renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; metastatic) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary clear cell adenocarcinoma, NOS of the kidney (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
Control | renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the kidney (subcutaneously implanted). |
colorectal cancer study 33 (carcinoma; colonic mucosa) / normal colon mucosa sample
Relative Expression (log2-ratio):-3.4661036Number of Samples:5 / 5
Experimental | colorectal cancer study 33 (carcinoma; colonic mucosa) |
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal carcinoma. | |
Control | normal colon mucosa sample |
Histopathological normal colon mucosa sample obtained by laser capture microdissection (LCM) from the distant normal colon of patients with colorectal cancer. |
expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO kidney cancer study 1 (granular cell carcinoma; primary)
Relative Expression (log2-ratio):3.3925695Number of Samples:22 / 4
Experimental | expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the kidney of patients with papillary adenocarcinoma (NOS). | |
Control | expO kidney cancer study 1 (granular cell carcinoma; primary) |
Primary tumor tissue samples obtained from the kidney of patients with granular cell carcinoma. |
ovarian tumor study 14 / normal ovarian surface epithelial cell sample
Relative Expression (log2-ratio):-3.3614302Number of Samples:4 / 4
Experimental | ovarian tumor study 14 |
Human pooled cancer samples from the ovary of patients with moderate and poorly differentiated serous carcinoma of the ovary. | |
Control | normal ovarian surface epithelial cell sample |
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from donors with non-cancerous, benign gynecological diseases. |
hepatocyte (ESC) / HepaRG
Relative Expression (log2-ratio):-3.3379793Number of Samples:8 / 12
Experimental | hepatocyte (ESC) |
Hepatocyte-like cells differentiated from embryonic stem cells (ESC) | |
Control | HepaRG |
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: |
PMA study 8 (0.0001 uM; Hep-G2) / vehicle (DMSO) treated Hep-G2 cell sample
Relative Expression (log2-ratio):-3.3166075Number of Samples:3 / 9
Experimental | PMA study 8 (0.0001 uM; Hep-G2) |
Hep-G2 cells exposed to 0.0001 uM PMA (dissolved in 0.5% v/v DMSO) for 72 hours. Synonyms: phorbol-12-myristat-13-acetate (PMA), tetradecanoylphorbol-acetate (TPA), tetradecanoyl phorbol acetate, 12-O-tetradecanoylphorbol-13-acetate. Cells were exposed to the chemical when 80% confluence was reached. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:--- | |
Control | vehicle (DMSO) treated Hep-G2 cell sample |
Hep-G2 cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Cells were exposed to the vehicle when 80% confluence was reached. |
colorectal adenoma study 7 (colonic mucosa) / normal colon mucosa sample
Relative Expression (log2-ratio):-3.2774038Number of Samples:5 / 5
Experimental | colorectal adenoma study 7 (colonic mucosa) |
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal adenoma. | |
Control | normal colon mucosa sample |
Histopathological normal colon mucosa sample obtained by laser capture microdissection (LCM) from the distant normal colon of patients with colorectal cancer. |
expO kidney cancer study 1 (renal cell carcinoma, NOS; primary) / expO kidney cancer study 1 (granular cell carcinoma; primary)
Relative Expression (log2-ratio):3.1949263Number of Samples:5 / 4
Experimental | expO kidney cancer study 1 (renal cell carcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the kidney of patients with renal cell carcinoma (NOS). | |
Control | expO kidney cancer study 1 (granular cell carcinoma; primary) |
Primary tumor tissue samples obtained from the kidney of patients with granular cell carcinoma. |
expO kidney cancer study 1 (renal cell carcinoma, sarcomatoid; primary) / expO kidney cancer study 1 (granular cell carcinoma; primary)
Relative Expression (log2-ratio):3.0395994Number of Samples:3 / 4
Experimental | expO kidney cancer study 1 (renal cell carcinoma, sarcomatoid; primary) |
Primary tumor tissue samples obtained from the kidney of patients with renal cell carcinoma, sarcomatoid. | |
Control | expO kidney cancer study 1 (granular cell carcinoma; primary) |
Primary tumor tissue samples obtained from the kidney of patients with granular cell carcinoma. |