TOP TEN perturbations for 38546_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38546_at
Selected probe(set): 205227_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38546_at (205227_at) across 6674 perturbations tested by GENEVESTIGATOR:
oligodendrocyte progenitor cell study 2 (O4-;CD140a+) / oligodendrocyte progenitor cell study 2 (O4-;CD140a-)
Relative Expression (log2-ratio):4.7809706Number of Samples:5 / 5
Experimental | oligodendrocyte progenitor cell study 2 (O4-;CD140a+) |
Fetal oligodendrocyte cells between 20-22wk gestational age derived from fetal brains were FACS sorted on the basis of CD140a (PDGFRA) antigens. Samples were O4-/CD140a+. | |
Control | oligodendrocyte progenitor cell study 2 (O4-;CD140a-) |
Fetal oligodendrocyte cells between 20-22wk gestational age derived from fetal brains were FACS sorted on the basis of CD140a (PDGFRA) antigens. Samples were O4-/CD140a-. |
CNS cancer study 1 (PDX; glioblastoma, NOS; primary) / CNS cancer study 1 (PDX; ependymoma, NOS; primary)
Relative Expression (log2-ratio):4.030299Number of Samples:3 / 2
Experimental | CNS cancer study 1 (PDX; glioblastoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioblastoma, NOS of the central nervous system (subcutaneously implanted). | |
Control | CNS cancer study 1 (PDX; ependymoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary ependymoma, NOS of the central nervous system (subcutaneously implanted). |
brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)
Relative Expression (log2-ratio):3.5747185Number of Samples:15 / 22
Experimental | brain tumor study 1 (pilocytic astrocytoma) |
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma. | |
Control | brain tumor study 1 (medulloblastoma) |
Primary tumor tissue sample from the brain of patients with medulloblastoma. |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; primary)
Relative Expression (log2-ratio):3.5075884Number of Samples:3 / 7
Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, sarcoma, NOS of the soft tissue (subcutaneously implanted). |
brain tumor study 1 (pilocytic astrocytoma) / normal brain tissue
Relative Expression (log2-ratio):3.460247Number of Samples:15 / 12
Experimental | brain tumor study 1 (pilocytic astrocytoma) |
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma. | |
Control | normal brain tissue |
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors. |
CNS cancer study 1 (PDX; glioma, malignant, NOS; primary) / CNS cancer study 1 (PDX; ependymoma, NOS; primary)
Relative Expression (log2-ratio):3.202817Number of Samples:2 / 2
Experimental | CNS cancer study 1 (PDX; glioma, malignant, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioma, malignant, NOS of the central nervous system (subcutaneously implanted). | |
Control | CNS cancer study 1 (PDX; ependymoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary ependymoma, NOS of the central nervous system (subcutaneously implanted). |
omeprazole study 6 (600uM) / vehicle (DMSO) treated hepatocyte sample
Relative Expression (log2-ratio):-3.143426Number of Samples:2 / 2
Experimental | omeprazole study 6 (600uM) |
Hepatocytes treated with compound: omeprazole (600uM; CHEMBL1503) for 24 hours. ATC code: | |
Control | vehicle (DMSO) treated hepatocyte sample |
Hepatocytes treated with vehicle (DMSO) for 24 hours. |
Langerhans cell histiocytosis study 1 / normal plasmocytoid dendritic cell sample
Relative Expression (log2-ratio):3.057376Number of Samples:7 / 3
Experimental | Langerhans cell histiocytosis study 1 |
Langerhans cell histiocytes (LCH) were isolated from LCH lesions of patients undergoing surgery. All patients had single system disease, five patients had bone lesion, one had skin lesion and one had mucosal manifestation. Langerhans cells histiocytes were purified by FACS as CD1a+ / CD270 + population with > 95% purity. | |
Control | normal plasmocytoid dendritic cell sample |
Normal plasmocytoid dendritic cells were isolated from peripheral blood of healthy adult donors. Plasmocytoid dendritic cells were defined as HLA-DR+ / CD45RAhi / CD11c- / BDCA2+ population. |
brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (ependymoma)
Relative Expression (log2-ratio):2.8418188Number of Samples:15 / 46
Experimental | brain tumor study 1 (pilocytic astrocytoma) |
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma. | |
Control | brain tumor study 1 (ependymoma) |
Primary tumor tissue sample from the brain of patients with ependymoma. |
succinate dehydrogenase B depletion study 1 (siRNA) / control siRNA transfected Hep3B cell sample
Relative Expression (log2-ratio):2.7636814Number of Samples:3 / 3
Experimental | succinate dehydrogenase B depletion study 1 (siRNA) |
Hep3B cells stably transfected with short hairpin vectors containing an siRNA directed to the subunit B of the succinate dehydrogenase. | |
Control | control siRNA transfected Hep3B cell sample |
Hep3B cells stably transfected with empty siRNA expression vector (pU6). |