TOP TEN perturbations for 38565_at (Homo sapiens)

Organism: Homo sapiens
Gene: 38565_at
Selected probe(set): 205670_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38565_at (205670_at) across 6674 perturbations tested by GENEVESTIGATOR:

renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; metastatic) / renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-5.0372057
Number of Samples:2 / 18
Experimental renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary clear cell adenocarcinoma, NOS of the kidney (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.
Control renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the kidney (subcutaneously implanted).

expO kidney cancer study 1 (neoplasm, malignant; primary) / expO kidney cancer study 1 (granular cell carcinoma; primary)

Relative Expression (log2-ratio):3.4257832
Number of Samples:2 / 4
Experimental expO kidney cancer study 1 (neoplasm, malignant; primary)
Primary tumor tissue samples obtained from the kidney of patients with malignant neoplasm.
Control expO kidney cancer study 1 (granular cell carcinoma; primary)
Primary tumor tissue samples obtained from the kidney of patients with granular cell carcinoma.

renal cell carcinoma study 1 (prim. tumor) / adjacent kidney tissue

Relative Expression (log2-ratio):3.2010221
Number of Samples:3 / 3
Experimental renal cell carcinoma study 1 (prim. tumor)
Tumor tissue from the primary tumor of patients with renal cell carcinoma (RCC).
Control adjacent kidney tissue
Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type.

PGC-1 overexpr. study 1 (2x9) / control transfected HEPG2 sample

Relative Expression (log2-ratio):2.8361073
Number of Samples:3 / 3
Experimental PGC-1 overexpr. study 1 (2x9)
HEP-G2 cells infected with adenoviruses carrying a mutant form of PPARG Coactivator 1 Alpha (PGC-1) where L2 and L3 motifs of PGC-1 were replaced with sequences corresponding to the L3-09 peptide (2x9). Cells were analyzed 24 hours after infection.
Control control transfected HEPG2 sample
HEp-G2 cells infected with adenoviruses carrying B-galactosidase as a control. Cells were analyzed 24 hours after infection.

expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO kidney cancer study 1 (neoplasm, malignant; primary)

Relative Expression (log2-ratio):-2.7140913
Number of Samples:22 / 2
Experimental expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the kidney of patients with papillary adenocarcinoma (NOS).
Control expO kidney cancer study 1 (neoplasm, malignant; primary)
Primary tumor tissue samples obtained from the kidney of patients with malignant neoplasm.

AsPC-1 / BxPC-3

Relative Expression (log2-ratio):2.7041283
Number of Samples:3 / 3
Experimental AsPC-1
Human xenograft derived metastatic cancer cell line derived from mouse xenografts initiated with metastatic cells from the ascites derived from a 62 years old female Caucasian patient with pancreatic adenocarcinoma. Synonyms:AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 Cellosaurus code:
Control BxPC-3
Human pancreatic adenocarcinoma cell line derived from a 61 years old female patient. Synonyms:BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3 Cellosaurus code:

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)

Relative Expression (log2-ratio):2.6505337
Number of Samples:15 / 22
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.

HCC study 20 (CDX; Hep-G2; ectopic) / HCC study 20 (PDX; ectopic)

Relative Expression (log2-ratio):-2.5878553
Number of Samples:3 / 11
Experimental HCC study 20 (CDX; Hep-G2; ectopic)
Tumor tissue biopsy samples from Hep-G2 cell line-derived xenograft (CDX) ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks.
Control HCC study 20 (PDX; ectopic)
Tumor tissue biopsy samples from patient-derived xenograft (PDX) sample ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. Donor tumor tissue was obtained intraoperatively during liver resection from three patients. All three patients had hepatocellular carcinoma confirmed by histology. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks.

PGC-1 overexpr. study 1 (WT) / control transfected HEPG2 sample

Relative Expression (log2-ratio):2.5875368
Number of Samples:3 / 3
Experimental PGC-1 overexpr. study 1 (WT)
HEP-G2 cells infected with adenoviruses carrying a wild-type form of PPARG Coactivator 1 Alpha (PGC-1). Cells were analyzed 24 hours after infection.
Control control transfected HEPG2 sample
HEp-G2 cells infected with adenoviruses carrying B-galactosidase as a control. Cells were analyzed 24 hours after infection.

clear cell renal cell carcinoma study 3 (non-obese; smoker) / smoking study 71 (non-obese)

Relative Expression (log2-ratio):2.5600958
Number of Samples:16 / 15
Experimental clear cell renal cell carcinoma study 3 (non-obese; smoker)
Tumor tissue from patients with clear cell renal cell carcinoma (ccRCC). Patients were smokers and had a BMI < 30 kg/m2. Patients with late T4 stage and grade 4 tumors were excluded.
Control smoking study 71 (non-obese)
Kidney tissue samples from non-obese smokers with a BMI < 30 kg/m2 and pack-years > 20.