TOP TEN perturbations for 38565_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38565_at
Selected probe(set): 205670_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38565_at (205670_at) across 6674 perturbations tested by GENEVESTIGATOR:
renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; metastatic) / renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; primary)
Relative Expression (log2-ratio):-5.0372057Number of Samples:2 / 18
Experimental | renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; metastatic) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary clear cell adenocarcinoma, NOS of the kidney (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
Control | renal cell carcinoma study 10 (PDX; clear cell adenocarcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary clear cell adenocarcinoma, NOS of the kidney (subcutaneously implanted). |
expO kidney cancer study 1 (neoplasm, malignant; primary) / expO kidney cancer study 1 (granular cell carcinoma; primary)
Relative Expression (log2-ratio):3.4257832Number of Samples:2 / 4
Experimental | expO kidney cancer study 1 (neoplasm, malignant; primary) |
Primary tumor tissue samples obtained from the kidney of patients with malignant neoplasm. | |
Control | expO kidney cancer study 1 (granular cell carcinoma; primary) |
Primary tumor tissue samples obtained from the kidney of patients with granular cell carcinoma. |
renal cell carcinoma study 1 (prim. tumor) / adjacent kidney tissue
Relative Expression (log2-ratio):3.2010221Number of Samples:3 / 3
Experimental | renal cell carcinoma study 1 (prim. tumor) |
Tumor tissue from the primary tumor of patients with renal cell carcinoma (RCC). | |
Control | adjacent kidney tissue |
Histologically normal tissue from an unaffected site (renal tubules) of patients with renal cell carcinoma (RCC) of the clear cell type. |
PGC-1 overexpr. study 1 (2x9) / control transfected HEPG2 sample
Relative Expression (log2-ratio):2.8361073Number of Samples:3 / 3
Experimental | PGC-1 overexpr. study 1 (2x9) |
HEP-G2 cells infected with adenoviruses carrying a mutant form of PPARG Coactivator 1 Alpha (PGC-1) where L2 and L3 motifs of PGC-1 were replaced with sequences corresponding to the L3-09 peptide (2x9). Cells were analyzed 24 hours after infection. | |
Control | control transfected HEPG2 sample |
HEp-G2 cells infected with adenoviruses carrying B-galactosidase as a control. Cells were analyzed 24 hours after infection. |
expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO kidney cancer study 1 (neoplasm, malignant; primary)
Relative Expression (log2-ratio):-2.7140913Number of Samples:22 / 2
Experimental | expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the kidney of patients with papillary adenocarcinoma (NOS). | |
Control | expO kidney cancer study 1 (neoplasm, malignant; primary) |
Primary tumor tissue samples obtained from the kidney of patients with malignant neoplasm. |
AsPC-1 / BxPC-3
Relative Expression (log2-ratio):2.7041283Number of Samples:3 / 3
Experimental | AsPC-1 |
Human xenograft derived metastatic cancer cell line derived from mouse xenografts initiated with metastatic cells from the ascites derived from a 62 years old female Caucasian patient with pancreatic adenocarcinoma. Synonyms:AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 Cellosaurus code: | |
Control | BxPC-3 |
Human pancreatic adenocarcinoma cell line derived from a 61 years old female patient. Synonyms:BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3 Cellosaurus code: |
brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)
Relative Expression (log2-ratio):2.6505337Number of Samples:15 / 22
Experimental | brain tumor study 1 (pilocytic astrocytoma) |
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma. | |
Control | brain tumor study 1 (medulloblastoma) |
Primary tumor tissue sample from the brain of patients with medulloblastoma. |
HCC study 20 (CDX; Hep-G2; ectopic) / HCC study 20 (PDX; ectopic)
Relative Expression (log2-ratio):-2.5878553Number of Samples:3 / 11
Experimental | HCC study 20 (CDX; Hep-G2; ectopic) |
Tumor tissue biopsy samples from Hep-G2 cell line-derived xenograft (CDX) ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks. | |
Control | HCC study 20 (PDX; ectopic) |
Tumor tissue biopsy samples from patient-derived xenograft (PDX) sample ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. Donor tumor tissue was obtained intraoperatively during liver resection from three patients. All three patients had hepatocellular carcinoma confirmed by histology. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks. |
PGC-1 overexpr. study 1 (WT) / control transfected HEPG2 sample
Relative Expression (log2-ratio):2.5875368Number of Samples:3 / 3
Experimental | PGC-1 overexpr. study 1 (WT) |
HEP-G2 cells infected with adenoviruses carrying a wild-type form of PPARG Coactivator 1 Alpha (PGC-1). Cells were analyzed 24 hours after infection. | |
Control | control transfected HEPG2 sample |
HEp-G2 cells infected with adenoviruses carrying B-galactosidase as a control. Cells were analyzed 24 hours after infection. |
clear cell renal cell carcinoma study 3 (non-obese; smoker) / smoking study 71 (non-obese)
Relative Expression (log2-ratio):2.5600958Number of Samples:16 / 15
Experimental | clear cell renal cell carcinoma study 3 (non-obese; smoker) |
Tumor tissue from patients with clear cell renal cell carcinoma (ccRCC). Patients were smokers and had a BMI < 30 kg/m2. Patients with late T4 stage and grade 4 tumors were excluded. | |
Control | smoking study 71 (non-obese) |
Kidney tissue samples from non-obese smokers with a BMI < 30 kg/m2 and pack-years > 20. |