TOP TEN perturbations for 38583_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38583_at
Selected probe(set): 217452_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38583_at (217452_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
stem cell differentiation study 59 (iDRG; 12d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):6.1460776Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (iDRG; 12d) |
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 9d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):5.9040837Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (iDRG; 9d) |
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 1 day. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (8d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):5.176412Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (8d) |
WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 15d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):5.138229Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (iDRG; 15d) |
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) / focal segmental glomerulosclerosis study 9 (glomerulus)
Relative Expression (log2-ratio):-4.1563835Number of Samples:21 / 10
Experimental | rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) |
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist. | |
Control | focal segmental glomerulosclerosis study 9 (glomerulus) |
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist. |
cytomegalovirus study 1 / C. albicans study 1
Relative Expression (log2-ratio):-4.108293Number of Samples:3 / 3
Experimental | cytomegalovirus study 1 |
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with CMV-antigens (lysate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC´s. | |
Control | C. albicans study 1 |
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with Candida albicans-antigens (sonicate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC´s. |
tetanus toxin study 1 / cytomegalovirus study 1
Relative Expression (log2-ratio):3.8043618Number of Samples:3 / 3
Experimental | tetanus toxin study 1 |
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with tetanus toxoid (tetanospasmin) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC´s. | |
Control | cytomegalovirus study 1 |
Peripheral blood mononuclear cell samples from healthy, HIV-negative individuals were CFSE labeled and stimulated with CMV-antigens (lysate) for 6 days. CFSE-low and pathogen-specific CD4+ T cell samples were isolated by FACS sorting from stimulated PBMC´s. |
hair follicle growth study 1 (P5) / hair follicle growth study 1 (P0)
Relative Expression (log2-ratio):3.8020258Number of Samples:3 / 3
Experimental | hair follicle growth study 1 (P5) |
Dermal papilla cells isolated from occipital scalp hair follicles obtained and cultured subsequent in two dimensional culture. Samples were taken at passage 5. | |
Control | hair follicle growth study 1 (P0) |
Dermal papilla cells isolated from occipital scalp hair follicles obtained and cultured subsequent in two dimensional culture. Samples were taken directly after cell explant outgrowth. |
dexamethasone study 7 (late) / vehicle treated HOb514 cell sample
Relative Expression (log2-ratio):3.680871Number of Samples:3 / 3
Experimental | dexamethasone study 7 (late) |
Primary human osteoblast like cells (HOb514) obtained from the trabecular bone of the proximal femoral shaft treated with 10-7 M dexamethasone for 24 hours. ATC code:, , , , , , , , , , | |
Control | vehicle treated HOb514 cell sample |
Primary human osteoblast like cells (HOb514) obtained from the trabecular bone of the proximal femoral shaft incubated with 10-4 mg/ml of vehicle for 24h. |
brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (ependymoma)
Relative Expression (log2-ratio):3.650003Number of Samples:15 / 46
Experimental | brain tumor study 1 (pilocytic astrocytoma) |
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma. | |
Control | brain tumor study 1 (ependymoma) |
Primary tumor tissue sample from the brain of patients with ependymoma. |