Organism: Homo sapiens
Gene: 38586_at
Selected probe(set): 205892_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38586_at (205892_s_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-7.0440483
Number of Samples:3 / 11

Experimental	HCC study 20 (CDX; Hep-G2; ectopic)
	Tumor tissue biopsy samples from Hep-G2 cell line-derived xenograft (CDX) ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks.
Control	HCC study 20 (PDX; ectopic)
	Tumor tissue biopsy samples from patient-derived xenograft (PDX) sample ectopically generated in SCID mice by injecting hepatocellular carcinoma cells subcutaneously. Donor tumor tissue was obtained intraoperatively during liver resection from three patients. All three patients had hepatocellular carcinoma confirmed by histology. In order to establish ectopic models, cells were injected subcutaneously into the flank regions. The mice were euthanized after two weeks.

Relative Expression (log2-ratio):-7.028611
Number of Samples:3 / 12

Experimental	4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (7500 uM; HepaRG)
	HepaRG cells exposed to 7500 uM 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (dissolved in 0.5% v/v DMSO) for 72 hours. Cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Chemical was added at day 19 of cultivation. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:---
Control	vehicle (DMSO) treated HepaRG cell sample
	HepaRG cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Firstly, cells were cultivated in DMSO-containing medium between days 13 - 19 to allow them to differentiate into hepatocyte-like cells and become fully functional. Then the vehicle was added.

Relative Expression (log2-ratio):-6.8996716
Number of Samples:2 / 19

Experimental	azathioprine study 8 (48h)
	HepG2 cells exposed to 250μM azathioprine in DMSO solvent for 48 hours. ATC code:
Control	vehicle (DMSO) treated HepG2 cell sample
	HepG2 cells exposed to DMSO solvent for 48 hours.

Relative Expression (log2-ratio):-6.690132
Number of Samples:19 / 69

Experimental	clear cell renal cell carcinoma study 4 (stage 2)
	Primary tumor tissue from patients with stage 2 clear cell renal cell carcinoma (ccRCC).
Control	normal kidney tissue
	Normal kidney tissue samples obtained from healthy individuals.

Relative Expression (log2-ratio):-6.566205
Number of Samples:14 / 69

Experimental	clear cell renal cell carcinoma study 4 (stage 3)
	Primary tumor tissue from patients with stage 3 clear cell renal cell carcinoma (ccRCC).
Control	normal kidney tissue
	Normal kidney tissue samples obtained from healthy individuals.

Relative Expression (log2-ratio):-6.341775
Number of Samples:3 / 3

Experimental	succinate dehydrogenase B depletion study 1 (siRNA)
	Hep3B cells stably transfected with short hairpin vectors containing an siRNA directed to the subunit B of the succinate dehydrogenase.
Control	control siRNA transfected Hep3B cell sample
	Hep3B cells stably transfected with empty siRNA expression vector (pU6).

Relative Expression (log2-ratio):-6.314866
Number of Samples:23 / 69

Experimental	clear cell renal cell carcinoma study 4 (stage 1)
	Primary tumor tissue from patients with stage 1 clear cell renal cell carcinoma (ccRCC).
Control	normal kidney tissue
	Normal kidney tissue samples obtained from healthy individuals.

Relative Expression (log2-ratio):-5.4880543
Number of Samples:14 / 69

Experimental	clear cell renal cell carcinoma study 4 (stage 4)
	Primary tumor tissue from patients with stage 4 clear cell renal cell carcinoma (ccRCC).
Control	normal kidney tissue
	Normal kidney tissue samples obtained from healthy individuals.

Relative Expression (log2-ratio):-5.304018
Number of Samples:5 / 11

Experimental	HCC study 20 (CDX; Hep-G2; orthotopic)
	Tumor tissue biopsy samples from Hep-G2 cell line-derived xenograft (CDX) orthotopically generated in SCID mice by injecting hepatocellular carcinoma cells directly into liver parenchyma. In order to establish orthotopic model, the left lobe of liver was exposed through midline abdominal incision and cells were injected directly into liver parenchyma of mice. The mice were euthanized after two weeks.
Control	HCC study 20 (PDX; orthotopic)
	Tumor tissue biopsy samples from patient-derived xenograft (PDX) sample orthotopically generated in SCID mice by injecting hepatocellular carcinoma cells directly into liver parenchyma. Donor tumor tissue was obtained intraoperatively during liver resection from three patients. All three patients had hepatocellular carcinoma confirmed by histology. In order to establish orthotopic model, the left lobe of liver was exposed through midline abdominal incision and cells were injected directly into liver parenchyma of mice. The mice were euthanized after two weeks.

Relative Expression (log2-ratio):-5.2852783
Number of Samples:2 / 3

Experimental	collecting duct carcinoma study 1
	Tumor tissue samples from the kidney of patients with collecting duct carcinoma (CDC).
Control	normal kidney tissue (adult)
	Normal adult kidney tissue samples.