TOP TEN perturbations for 38596_i_at (Homo sapiens)

Organism: Homo sapiens
Gene: 38596_i_at
Selected probe(set): 210423_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38596_i_at (210423_s_at) across 6674 perturbations tested by GENEVESTIGATOR:

LPS study 4 (shRNA contr.) / mock treated / transduced MONO-MAC-6 cell sample

Relative Expression (log2-ratio):4.1856527
Number of Samples:2 / 2
Experimental LPS study 4 (shRNA contr.)
MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control mock treated / transduced MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then mock treated.

glioma study 17 (anaplastic astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)

Relative Expression (log2-ratio):4.1825113
Number of Samples:2 / 3
Experimental glioma study 17 (anaplastic astrocytoma; A2B5+)
Oligodendrocyte progenitor cells (OPC) isolated from high grade anaplastic astrocytoma (grade III). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 45 ± 18 years old.
Control non-tumor oligodendrocyte progenitor cell sample (cortex)
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

LPS study 4 / mock treated MONO-MAC-6 cell sample

Relative Expression (log2-ratio):4.085868
Number of Samples:2 / 2
Experimental LPS study 4
MONO-MAC-6 (MM6) cells were treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control mock treated MONO-MAC-6 cell sample
MONO-MAC-6 (MM6) cells mock treated.

calcitriol study 7 (10nM; 18h) / vitamin A study 3 (10nM; 18h)

Relative Expression (log2-ratio):3.3427124
Number of Samples:4 / 4
Experimental calcitriol study 7 (10nM; 18h)
Peripheral blood monocyte samples derived from blood of healthy donors and treated with 10 nM calcitriol (1alpha, 25-Dihydroxyvitamin D3; 1,25(OH)2D3) for 18 h. ATC code:,
Control vitamin A study 3 (10nM; 18h)
Peripheral blood monocyte samples derived from blood of healthy donors and treated with 10 nM ATRA (all-trans retinoic acid, biologically active form of vitamin A) for 18 h. ATC code:---

glioma study 17 (glioblastoma; unsorted) / non-tumor cortical tissue

Relative Expression (log2-ratio):3.3272152
Number of Samples:2 / 4
Experimental glioma study 17 (glioblastoma; unsorted)
Brain cells isolated from high grade glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation.
Control non-tumor cortical tissue
Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses.

myocardial infarction study 7 (validation) / normal vascular endothelium cell sample (validation)

Relative Expression (log2-ratio):3.2942114
Number of Samples:23 / 25
Experimental myocardial infarction study 7 (validation)
Circulating CD146+ endothelial cells (CECs) isolated from patients with acute myocardial infarction (AMI) with or without ST segment deviation assigned to the validation dataset. Arterial blood was collected in the cardiac catheterization laboratory following the placement of an arterial sheath prior to introduction of any guide wires or coronary catheters. The samples were maintained at room temperature and processed within 36 hours of collection. CECs were enriched from whole blood using CD146+ immunomagnetic separation and enumerated using the CellSearch system. AMI patients met strict diagnostic criteria including chest pain symptoms with electrocardiographic evidence of ST-segment elevation of at least 0.2 mV in two contiguous precordial leads or 0.1 mV in limb leads in addition to angiographic evidence of obstructive coronary artery disease in the setting of positive cardiac biomarkers. Inclusion criteria: 18 - 80 years of age; reliable, cooperative and willing to comply with all protocol-specified procedures if consented; able to understand and grant informed consent; acute MI defined as: clinical history and symptoms consistent with acute MI AND elevated cardiac markers (CKMB, Troponin I or T) consistent with MI AND able to complete study enrollment (consent & blood draw) within 48 hours of presentation to the study site. Exclusion criteria: significant medical condition that in the investigator's opinion may interfere with the patient's optimal participation in the study.
Control normal vascular endothelium cell sample (validation)
Circulating CD146+ endothelial cells (CECs) isolated from healthy control patients assigned to the validation dataset. CECs were enriched from whole blood using CD146+ immunomagnetic separation and enumerated using the CellSearch system. Inclusion criteria: 18-35 years of age; reliable, cooperative and willing to comply with all protocol-specified procedures if consented; able to understand and grant informed consent. Exclusion criteria: previous history of coronary artery disease or MI; Diabetes; Peripheral arterial disease; Hypertension (>140/90 or on blood pressure medication); sickle cell disease; acute or chronic kidney disease; acute or chronic vascular conditions, not otherwise specified; active or history of inflammation of connective tissue and vascular structures (i.e. vasculitis, rheumatoid arthritis).

HIV-associated neurocognitive disorder study 4 (ischemia) / normal genu sample

Relative Expression (log2-ratio):3.1782637
Number of Samples:2 / 8
Experimental HIV-associated neurocognitive disorder study 4 (ischemia)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with ischemia. The patients did not receive any antiretroviral therapy (ART).
Control normal genu sample
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from healthy subjects.

thermal injury study 1 (0-3d) / normal skin tissue

Relative Expression (log2-ratio):3.041831
Number of Samples:3 / 3
Experimental thermal injury study 1 (0-3d)
Burn wound margin samples of the skin 0-3 days post thermal injury.
Control normal skin tissue
Normal skin tissue sample.

thermal injury study 1 (4-7d) / normal skin tissue

Relative Expression (log2-ratio):2.912507
Number of Samples:3 / 3
Experimental thermal injury study 1 (4-7d)
Burn wound margin samples of the skin 4-7 days post thermal injury.
Control normal skin tissue
Normal skin tissue sample.

B-ALL study 1 (hyperdiploid) / normal bone marrow sample

Relative Expression (log2-ratio):-2.870202
Number of Samples:40 / 74
Experimental B-ALL study 1 (hyperdiploid)
Bone marrow samples of patients with hyperdiploid B-ALL (hyperdiploid karyotype).
Control normal bone marrow sample
Non-leukemic and healthy bone marrow sample.