Organism: Homo sapiens
Gene: 38610_s_at
Selected probe(set): 207023_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38610_s_at (207023_x_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-5.3320293
Number of Samples:2 / 10

Experimental	Langerhans cell histiocytosis study 2 (multisystem)
	Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with multifocal, multisystem (disseminated) disease. Both patients received chemotherapy. Sites of LCH lesions: subj.ID:1 (skin, lungs, multiple skull, mastoid, gingiva), subj.ID:13 (mandible, skull, vertebrae, recurrent orbit, liver, spleen, pituitary gland).
Control	normal epidermal Langerhans cell sample
	Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue.

Relative Expression (log2-ratio):-4.8083572
Number of Samples:8 / 10

Experimental	Langerhans cell histiocytosis study 2 (unifocal)
	Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with unifocal, single system disease (bone lesion).
Control	normal epidermal Langerhans cell sample
	Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue.

Relative Expression (log2-ratio):-4.790332
Number of Samples:2 / 10

Experimental	Langerhans cell histiocytosis study 2 (multifocal)
	Langerhans cell histiocytes (LCH, CD207+) samples isolated from LCH lesions of patients with multifocal (bone, skin lesions) disease.
Control	normal epidermal Langerhans cell sample
	Normal epidermal Langerhans cells (CD207+) were isolated from skin of children donors (age < 18 years). The Langerhans cells were isolated from presumably healthy tissue.

Relative Expression (log2-ratio):-4.2852173
Number of Samples:11 / 64

Experimental	Merkel cell carcinoma study 3 (metastatic)
	Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control	normal skin tissue
	Normal skin samples from healthy donors.

Relative Expression (log2-ratio):-3.7836895
Number of Samples:19 / 64

Experimental	Merkel cell carcinoma study 3 (primary)
	Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control	normal skin tissue
	Normal skin samples from healthy donors.

Relative Expression (log2-ratio):-3.3276014
Number of Samples:40 / 2

Experimental	melanoma study 34 (metastatic)
	Metastatic tumor tissue sample obtained from the patients with metastatic malignant melanoma of the skin. Metastatic samples composed of 22 macroscopic lymph node metastases, 16 subcutaneous metastases and 2 solid organ metastases (adrenal and brain).
Control	melanoma study 34 (in situ)
	Tumor tissue from the skin of patients with melanoma in situ.

Relative Expression (log2-ratio):-3.243596
Number of Samples:40 / 4

Experimental	melanoma study 34 (metastatic)
	Metastatic tumor tissue sample obtained from the patients with metastatic malignant melanoma of the skin. Metastatic samples composed of 22 macroscopic lymph node metastases, 16 subcutaneous metastases and 2 solid organ metastases (adrenal and brain).
Control	normal skin tissue
	Normal skin tissue.

Relative Expression (log2-ratio):3.2379913
Number of Samples:2 / 2

Experimental	keratinocyte differentiation study 2 (KLF4 siRNA)
	KLF4 (Kruppel-like factor 4) depleted primary neonatal keratinocytes differentiated with 1.2 mM calcium for 3 days. Keratinocytes obtained from freshly isolated foreskin were grown in keratinocyte-SFM medium supplemented with epidermal growth factor and bovine pituitary extract. KLF4 depletion was done using siRNAs: KLF4i(A): CCGAGGAGTTCAACGATCT; KLF4i(B): TGACCAGGCACTACCGTAA. Differentiation was induced at 100% confluency.
Control	keratinocyte differentiation study 2
	Primary neonatal keratinocytes differentiated with 1.2 mM calcium for 3 days. Keratinocytes obtained from freshly isolated foreskin were grown in keratinocyte-SFM medium supplemented with epidermal growth factor and bovine pituitary extract. Differentiation was induced at 100% confluency.

Relative Expression (log2-ratio):-3.104618
Number of Samples:3 / 3

Experimental	oncolytic herpes simplex virus study 2
	Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control	mock infected peripheral nerve sheath tumor (S462) cell sample
	Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours.

Relative Expression (log2-ratio):-3.079895
Number of Samples:3 / 3

Experimental	wound healing study 2 (ex vivo; DMSO)
	Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing DMSO for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 1:1000 fold dilution of DMSO. The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin.
Control	normal skin tissue (ex vivo)
	Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.