TOP TEN perturbations for 38653_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38653_at
Selected probe(set): 210139_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38653_at (210139_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
conditioned medium study 1 (HS27a) / untreated monocyte (CD14+) sample
Relative Expression (log2-ratio):6.281067Number of Samples:2 / 2
Experimental | conditioned medium study 1 (HS27a) |
CD14+ monocytes treated with HS27a conditioned medium (CM) for 48h. | |
Control | untreated monocyte (CD14+) sample |
Untreated CD14+ monocytes from two different donors. |
conditioned medium study 1 (HS5) / untreated monocyte (CD14+) sample
Relative Expression (log2-ratio):6.27293Number of Samples:2 / 2
Experimental | conditioned medium study 1 (HS5) |
CD14+ monocytes treated with HS5 conditioned medium (CM) for 48h. | |
Control | untreated monocyte (CD14+) sample |
Untreated CD14+ monocytes from two different donors. |
basal cell carcinoma study 3 / normal epidermal keratinocytes
Relative Expression (log2-ratio):5.427552Number of Samples:4 / 2
Experimental | basal cell carcinoma study 3 |
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC). | |
Control | normal epidermal keratinocytes |
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2. |
lung cancer study 1 (PDX; non-small cell carcinoma; primary) / lung cancer study 1 (PDX; basaloid carcinoma; primary)
Relative Expression (log2-ratio):4.8064795Number of Samples:2 / 3
Experimental | lung cancer study 1 (PDX; non-small cell carcinoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary non-small cell carcinoma of the lung (subcutaneously implanted). | |
Control | lung cancer study 1 (PDX; basaloid carcinoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary basaloid carcinoma of the lung (subcutaneously implanted). |
SDF study 4 / untreated MDA Mb231 cell sample
Relative Expression (log2-ratio):-4.80608Number of Samples:3 / 6
Experimental | SDF study 4 |
MDA Mb231 cells treated with 75nM stromal derived factor (SDF; Cxcl12) for 6h. | |
Control | untreated MDA Mb231 cell sample |
Untreated MDA Mb231 cells harvested after 6h. |
breast cancer study 24 / breast cancer study 22
Relative Expression (log2-ratio):4.308852Number of Samples:10 / 10
Experimental | breast cancer study 24 |
Freshly purified CD4+ tumor-infiltrating T cells derived from female primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information. The initial tissue dissociation was performed mechanically, without enzymatic digestion. | |
Control | breast cancer study 22 |
Freshly purified CD4+ T cells from peripheral blood of female donors with primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information. |
HCC study 20 (CDX; Hep-G2; orthotopic) / HCC study 20 (PDX; orthotopic)
Relative Expression (log2-ratio):4.19884Number of Samples:5 / 11
Experimental | HCC study 20 (CDX; Hep-G2; orthotopic) |
Tumor tissue biopsy samples from Hep-G2 cell line-derived xenograft (CDX) orthotopically generated in SCID mice by injecting hepatocellular carcinoma cells directly into liver parenchyma. In order to establish orthotopic model, the left lobe of liver was exposed through midline abdominal incision and cells were injected directly into liver parenchyma of mice. The mice were euthanized after two weeks. | |
Control | HCC study 20 (PDX; orthotopic) |
Tumor tissue biopsy samples from patient-derived xenograft (PDX) sample orthotopically generated in SCID mice by injecting hepatocellular carcinoma cells directly into liver parenchyma. Donor tumor tissue was obtained intraoperatively during liver resection from three patients. All three patients had hepatocellular carcinoma confirmed by histology. In order to establish orthotopic model, the left lobe of liver was exposed through midline abdominal incision and cells were injected directly into liver parenchyma of mice. The mice were euthanized after two weeks. |
stem cell differentiation study 59 (iDRG; 15d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):4.1982756Number of Samples:4 / 4
Experimental | stem cell differentiation study 59 (iDRG; 15d) |
Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
Control | normal embryonic stem cell sample (WA09) |
Undifferentiated WA09 embryonic stem cell samples. |
bladder cancer study 1 / normal bladder tissue
Relative Expression (log2-ratio):-3.9976435Number of Samples:3 / 3
Experimental | bladder cancer study 1 |
Low grade superficial tumor samples. | |
Control | normal bladder tissue |
Normal bladder tissue. |
ovarian tumor study 16 / normal ovarian surface epithelial cell sample
Relative Expression (log2-ratio):-3.9401226Number of Samples:3 / 5
Experimental | ovarian tumor study 16 |
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM). | |
Control | normal ovarian surface epithelial cell sample |
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue. |