TOP TEN perturbations for 38665_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38665_at
Selected probe(set): 203166_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38665_at (203166_at) across 6674 perturbations tested by GENEVESTIGATOR:
PMA; ionomycine study 2 / unstimulated CD4 memory T-cell sample
Relative Expression (log2-ratio):-2.7761335Number of Samples:8 / 8
Experimental | PMA; ionomycine study 2 |
CD4+ memory T cells derived from peripheral blood of healthy subjects were stimulated for 3 hours with phorbol 12-myristate 13-acetate (PMA, 10 ng/ml) and ionomycin (1 µg/ml). ATC code:--- | |
Control | unstimulated CD4 memory T-cell sample |
Unstimulated CD4+ memory T cells derived from peripheral blood of healthy subjects. |
zalypsis study 2 / untreated OPM1 cell sample
Relative Expression (log2-ratio):-2.628148Number of Samples:2 / 2
Experimental | zalypsis study 2 |
OPM1 multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:--- | |
Control | untreated OPM1 cell sample |
OPM1 multiple myeloma cells untreated. |
dendritic cell study 6 (gardiquimod) / dendritic cell study 6 (untreated)
Relative Expression (log2-ratio):-2.3871078Number of Samples:7 / 8
Experimental | dendritic cell study 6 (gardiquimod) |
Plasmacytoid dendritic cells (pDCs) collected from blood of healthy donors and treated with gardiquimod (TLR7 agonist) for 3 hours. pDCs were sorted as CD303+, CD123+, CD45+, CD69+, CD40+, CD86+. | |
Control | dendritic cell study 6 (untreated) |
Plasmacytoid dendritic cells (pDCs) collected from blood of healthy donors. pDCs were sorted as CD303+, CD123+, CD45+, CD69+, CD40+, CD86+. |
lung adenocarcinoma study 9 (metastase; lymph node) / lung adenocarcinoma study 9 (metastase; brain)
Relative Expression (log2-ratio):-2.3050451Number of Samples:3 / 6
Experimental | lung adenocarcinoma study 9 (metastase; lymph node) |
Metastatic tumor tissue obtained from the lymph node of patients with primary lung adenocarcinoma. | |
Control | lung adenocarcinoma study 9 (metastase; brain) |
Metastatic tumor tissue obtained from the brain of patients with primary lung adenocarcinoma. |
MALT lymphoma study 2 / normal spleen tissue
Relative Expression (log2-ratio):-2.192398Number of Samples:6 / 6
Experimental | MALT lymphoma study 2 |
Human t(11;18)-positive mucosa-associated lymphoid tissue (MALT) lymphoma cells. | |
Control | normal spleen tissue |
Normal human spleen tissue sample. |
ovarian tumor study 16 / normal ovarian surface epithelial cell sample
Relative Expression (log2-ratio):-2.1659288Number of Samples:3 / 5
Experimental | ovarian tumor study 16 |
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM). | |
Control | normal ovarian surface epithelial cell sample |
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue. |
IL-4; GM-CSF study 1 (early) / untreated monocyte sample
Relative Expression (log2-ratio):-2.124467Number of Samples:6 / 12
Experimental | IL-4; GM-CSF study 1 (early) |
Monocytes, cultured with vehicle (DMSO/ethanol) and 500 U/ml IL-4 and 800 U/ml GM-CSF for 6 hours. | |
Control | untreated monocyte sample |
Freshly isolated human monocytes from healthy donors. |
oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample
Relative Expression (log2-ratio):-2.1223345Number of Samples:3 / 3
Experimental | oncolytic herpes simplex virus study 2 |
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours. | |
Control | mock infected peripheral nerve sheath tumor (S462) cell sample |
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours. |
ovarian tumor study 13 / normal ovarian surface epithelial cell sample
Relative Expression (log2-ratio):-2.1014595Number of Samples:18 / 12
Experimental | ovarian tumor study 13 |
Human epithelial tumor cell samples from the ovary of patients with serous adenocarcinoma. Samples were derived by laser capture microdissection (LCM). | |
Control | normal ovarian surface epithelial cell sample |
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from healthy donors. Samples were derived by cell surface brushing. |
ovarian tumor study 25 (serous ovarian cancer epithelium) / normal ovarian surface epithelium cell sample
Relative Expression (log2-ratio):-1.9674835Number of Samples:12 / 12
Experimental | ovarian tumor study 25 (serous ovarian cancer epithelium) |
Laser capture micro-dissected serous ovarian cancer epithelium cells derived from female individuals with primary papillary serous adenocarcinoma of the ovary. | |
Control | normal ovarian surface epithelium cell sample |
Normal ovarian surface epithelium cell (OSE) samples isolated from female individuals by laser capture micro-dissection (LCM). Indication for removal of healthy ovaries were others than ovary cancer. |