TOP TEN perturbations for 38760_f_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38760_f_at
Selected probe(set): 209846_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38760_f_at (209846_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
necrotizing myopathy study 2 / inclusion body myositis study 2
Relative Expression (log2-ratio):-4.5263844Number of Samples:2 / 5
Experimental | necrotizing myopathy study 2 |
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of necrotizing myopathy (NM). | |
Control | inclusion body myositis study 2 |
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM). |
glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)
Relative Expression (log2-ratio):4.2314596Number of Samples:3 / 3
Experimental | glioma study 17 (glioblastoma; A2B5+) |
Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males. | |
Control | non-tumor oligodendrocyte progenitor cell sample (cortex) |
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. |
inclusion body myositis study 2 / normal quadriceps tissue
Relative Expression (log2-ratio):4.058275Number of Samples:5 / 2
Experimental | inclusion body myositis study 2 |
Quadriceps femoris biopsy muscle samples from patients with clinical diagnosis of inclusion body myositis (IBM). | |
Control | normal quadriceps tissue |
Quadriceps femoris biopsy muscle samples from control subjects. |
glioma study 17 (anaplastic astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)
Relative Expression (log2-ratio):3.995615Number of Samples:2 / 3
Experimental | glioma study 17 (anaplastic astrocytoma; A2B5+) |
Oligodendrocyte progenitor cells (OPC) isolated from high grade anaplastic astrocytoma (grade III). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 45 ± 18 years old. | |
Control | non-tumor oligodendrocyte progenitor cell sample (cortex) |
Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. |
IL-1b; IFN-g study 1 (84hrs) / untreated pancreatic islet sample (84hrs)
Relative Expression (log2-ratio):3.5839443Number of Samples:3 / 3
Experimental | IL-1b; IFN-g study 1 (84hrs) |
Pancreatic islets isolated by collagenase digestion from brain-dead organ donors and cultured 3-5 days in RPMI 1640 medium containing 5.6 mM glucose, 10% FCS and 2 mM L-glutamine. Thereafter, islets were cultured in presence of human recombinant IL-1b (25 units/ml) and IFN-g (1,000 units/ml) for 84 hours. Media were changed after 2 days. | |
Control | untreated pancreatic islet sample (84hrs) |
Untreated pancreatic islets isolated by collagenase digestion from brain-dead organ donors and cultured 3-5 days in RPMI 1640 medium containing 5.6 mM glucose, 10% FCS and 2 mM L-glutamine. Thereafter, islets were cultured in fresh media and harvested after 84 hours. Media were changed after 2 days. |
IL-1b; IFN-g study 1 (132hrs) / untreated pancreatic islet sample (132hrs)
Relative Expression (log2-ratio):3.512189Number of Samples:2 / 2
Experimental | IL-1b; IFN-g study 1 (132hrs) |
Pancreatic islets isolated by collagenase digestion from brain-dead organ donors and cultured 3-5 days in RPMI 1640 medium containing 5.6 mM glucose, 10% FCS and 2 mM L-glutamine. Thereafter, islets were cultured in presence of human recombinant IL-1b (25 units/ml) and IFN-g (1,000 units/ml) for 132 hours. Media were changed after 2 and 5 days. | |
Control | untreated pancreatic islet sample (132hrs) |
Untreated pancreatic islets isolated by collagenase digestion from brain-dead organ donors and cultured 3-5 days in RPMI 1640 medium containing 5.6 mM glucose, 10% FCS and 2 mM L-glutamine. Thereafter, islets were cultured in fresh media and harvested after 132 hours. Media were changed after 2 and 5 days. |
glioma study 17 (glioblastoma; unsorted) / non-tumor cortical tissue
Relative Expression (log2-ratio):3.500061Number of Samples:2 / 4
Experimental | glioma study 17 (glioblastoma; unsorted) |
Brain cells isolated from high grade glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation. | |
Control | non-tumor cortical tissue |
Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses. |
TNF-ɑ; TGF-ß2 study 1 (late) / untreated ARPE-19 cell sample
Relative Expression (log2-ratio):3.3751068Number of Samples:6 / 3
Experimental | TNF-ɑ; TGF-ß2 study 1 (late) |
ARPE-19 retina pigment epithelial cell samples treated with TNF-ɑ (10 ng/ml) and TGF-ß2 (5 ng/ml). Samples were taken 42 and 60 hours after treatment. | |
Control | untreated ARPE-19 cell sample |
Untreated ARPE-19 retina pigment epithelial cell samples harvested before adding TNF-ɑ (10 ng/ml) and TGF-ß2 (5 ng/ml). |
expO breast cancer study 1 (medullary carcinoma, NOS; primary) / expO breast cancer study 1 (inflammatory carcinoma; primary)
Relative Expression (log2-ratio):3.318142Number of Samples:2 / 2
Experimental | expO breast cancer study 1 (medullary carcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the breast of patients with medullary carcinoma (NOS). | |
Control | expO breast cancer study 1 (inflammatory carcinoma; primary) |
Primary tumor tissue samples obtained from the breast of patients with inflammatory carcinoma. |
rhegmatogenous retinal detachment study 1 / normal retina tissue
Relative Expression (log2-ratio):3.3152332Number of Samples:19 / 17
Experimental | rhegmatogenous retinal detachment study 1 |
Retina tissue samples from patients with retinal detachment obtained by vitrectomy. | |
Control | normal retina tissue |
Postmortem retina tissue samples from healthy patients without any diseases of the eye. |