TOP TEN perturbations for 38796_at (Homo sapiens)

Organism: Homo sapiens
Gene: 38796_at
Selected probe(set): 202953_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 38796_at (202953_at) across 6674 perturbations tested by GENEVESTIGATOR:

DLBCL study 7 (GCB; plasmablast-like) / DLBCL study 7 (GCB; naive-like)

Relative Expression (log2-ratio):6.218974
Number of Samples:3 / 2
Experimental DLBCL study 7 (GCB; plasmablast-like)
Primary tumor samples from patients with diffuse large B-cell lymphoma (germinal center B-cell like type). Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to plasmablast-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation.
Control DLBCL study 7 (GCB; naive-like)
Primary tumor samples from patients with diffuse large B-cell lymphoma (germinal center B-cell like type). Samples were also classified based on subset-specific B-cell-associated gene signature (BAGS) and assigned to naive-like group. Patients were treated according to standard protocols, and comparable doses of RCHOP- like regimens were used. No patient was treated with stem cell transplantation.

expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)

Relative Expression (log2-ratio):-5.42124
Number of Samples:2 / 2
Experimental expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic)
Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary.
Control expO ovary cancer study 1 (dysgerminoma; metastatic)
Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary.

retina pigment epithelium study 1 (adult) / retina pigment epithelium study 1 (fetal)

Relative Expression (log2-ratio):5.2550907
Number of Samples:2 / 6
Experimental retina pigment epithelium study 1 (adult)
Postmortem human native retina pigment epithelium samples from adult individuals.
Control retina pigment epithelium study 1 (fetal)
Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18.

collecting duct carcinoma study 1 / normal kidney tissue (fetal)

Relative Expression (log2-ratio):5.125787
Number of Samples:2 / 2
Experimental collecting duct carcinoma study 1
Tumor tissue samples from the kidney of patients with collecting duct carcinoma (CDC).
Control normal kidney tissue (fetal)
Normal fetal kidney tissue samples.

expO kidney cancer study 1 (renal cell carcinoma, sarcomatoid; primary) / expO kidney cancer study 1 (granular cell carcinoma; primary)

Relative Expression (log2-ratio):5.124916
Number of Samples:3 / 4
Experimental expO kidney cancer study 1 (renal cell carcinoma, sarcomatoid; primary)
Primary tumor tissue samples obtained from the kidney of patients with renal cell carcinoma, sarcomatoid.
Control expO kidney cancer study 1 (granular cell carcinoma; primary)
Primary tumor tissue samples obtained from the kidney of patients with granular cell carcinoma.

renal cell carcinoma study 4 / normal kidney tissue (fetal)

Relative Expression (log2-ratio):5.0513096
Number of Samples:26 / 2
Experimental renal cell carcinoma study 4
Tumor tissue samples from the kidney of patients with renal cell carcinoma (RCC).
Control normal kidney tissue (fetal)
Normal fetal kidney tissue samples.

pediatric meningococcal sepsis study 1 (24h; monocyte) / normal monocyte (CD14+) sample

Relative Expression (log2-ratio):4.652648
Number of Samples:3 / 3
Experimental pediatric meningococcal sepsis study 1 (24h; monocyte)
Monocyte (CD14+) samples obtained from blood samples of children with (suspected) meningococcal sepsis collected 24 hours after admission to the pediatric intensive care unit (PICU). Granulocytes and peripheral blood mononuclear cells (PBMCs) were isolated. From the PBMCs, CD14+ cells (monocytes) and CD14- cells (enriched for B- and T-cells) were separated using autoMACS sorting.
Control normal monocyte (CD14+) sample
Normal monocyte (CD14+) samples obtained from peripheral blood of healthy children admitted for elective minor non-infectious surgery or MRI. Ten ml of whole blood samples were used to perform a Ficoll density separation using Lymphoprep. Granulocytes and peripheral blood mononuclear cells (PBMCs) were isolated. From the PBMCs, CD14+ cells (monocytes) and CD14- cells (enriched for B- and T-cells) were separated using autoMACS sorting.

cutaneous T-cell lymphoma study 1 (tumor phase) / normal skin tissue

Relative Expression (log2-ratio):4.546688
Number of Samples:4 / 8
Experimental cutaneous T-cell lymphoma study 1 (tumor phase)
Lesional skin biopsies from patients with cutaneous T-cell lymphoma in the tumor phase (extranodal).
Control normal skin tissue
Skin biopsies from healthy individuals.

breast cancer study 24 / breast cancer study 22

Relative Expression (log2-ratio):4.537382
Number of Samples:10 / 10
Experimental breast cancer study 24
Freshly purified CD4+ tumor-infiltrating T cells derived from female primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information. The initial tissue dissociation was performed mechanically, without enzymatic digestion.
Control breast cancer study 22
Freshly purified CD4+ T cells from peripheral blood of female donors with primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information.

pediatric meningococcal sepsis study 1 (8h; monocyte) / normal monocyte (CD14+) sample

Relative Expression (log2-ratio):4.4298916
Number of Samples:3 / 3
Experimental pediatric meningococcal sepsis study 1 (8h; monocyte)
Monocyte (CD14+) samples obtained from blood samples of children with (suspected) meningococcal sepsis collected 8 hours after admission to the pediatric intensive care unit (PICU). Granulocytes and peripheral blood mononuclear cells (PBMCs) were isolated. From the PBMCs, CD14+ cells (monocytes) and CD14- cells (enriched for B- and T-cells) were separated using autoMACS sorting.
Control normal monocyte (CD14+) sample
Normal monocyte (CD14+) samples obtained from peripheral blood of healthy children admitted for elective minor non-infectious surgery or MRI. Ten ml of whole blood samples were used to perform a Ficoll density separation using Lymphoprep. Granulocytes and peripheral blood mononuclear cells (PBMCs) were isolated. From the PBMCs, CD14+ cells (monocytes) and CD14- cells (enriched for B- and T-cells) were separated using autoMACS sorting.