TOP TEN perturbations for 38912_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38912_at
Selected probe(set): 206797_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38912_at (206797_at) across 6674 perturbations tested by GENEVESTIGATOR:
HCC study 18 (very advanced) / normal liver tissue
Relative Expression (log2-ratio):-5.186803Number of Samples:3 / 10
Experimental | HCC study 18 (very advanced) |
Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded. | |
Control | normal liver tissue |
Normal liver tissue samples obtained from the healthy livers of patients undergoing resection for hepatic hemangioma, focal nodular hyperplasia, adenoma/cystadenoma, neuroendocrine tumor, and living donor liver transplantation. |
HCC study 27 (young; training) / normal liver tissue (young; training)
Relative Expression (log2-ratio):-4.7739105Number of Samples:16 / 15
Experimental | HCC study 27 (young; training) |
Primary tumor tissue samples obtained from the liver of young patients (≤ 40 years old) with hepatocellular carcinoma assigned to a training cohort. | |
Control | normal liver tissue (young; training) |
Normal liver tissue samples obtained from young patients (≤ 40 years old) with hepatocellular carcinoma (HCC) assigned to a training cohort. |
HCC study 18 (very advanced) / dysplastic liver nodule study 1
Relative Expression (log2-ratio):-4.591961Number of Samples:3 / 17
Experimental | HCC study 18 (very advanced) |
Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded. | |
Control | dysplastic liver nodule study 1 |
Dysplastic nodule tissue samples obtained from liver of HCV infected patients undergoing resection or liver transplantation. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded. |
HCC study 23 (portal vein infiltration) / adjacent liver tissue
Relative Expression (log2-ratio):-4.5662193Number of Samples:3 / 10
Experimental | HCC study 23 (portal vein infiltration) |
Tumor liver tissue samples derived from patients with hepatocellular carcinoma (HCC) with portal vein infiltration. Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai. | |
Control | adjacent liver tissue |
Normal adjacent liver tissue samples derived from patients with hepatocellular carcinoma (HCC). Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai. |
HCC study 9 (HBV; HCV) / normal liver tissue
Relative Expression (log2-ratio):-4.2520943Number of Samples:2 / 10
Experimental | HCC study 9 (HBV; HCV) |
Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection. | |
Control | normal liver tissue |
Normal, non-tumor liver tissue. |
HCC study 9 (HBV) / normal liver tissue
Relative Expression (log2-ratio):-4.11273Number of Samples:10 / 10
Experimental | HCC study 9 (HBV) |
Liver tissue biopsy sample from patients with Hepatitis B infection related hepatocellular carcinoma (HCC) after resection. | |
Control | normal liver tissue |
Normal, non-tumor liver tissue. |
Hep-G2 / HepaRG
Relative Expression (log2-ratio):-4.0530376Number of Samples:9 / 12
Experimental | Hep-G2 |
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code: | |
Control | HepaRG |
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: |
HCC study 18 (very advanced) / hepatitis C study 10
Relative Expression (log2-ratio):-4.038005Number of Samples:3 / 13
Experimental | HCC study 18 (very advanced) |
Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded. | |
Control | hepatitis C study 10 |
Cirrhotic tissue samples obtained from liver of HCV infected patients undergoing resection or liver transplantation. Ten out of 13 samples were obtained from patients with hepatocellular carcinoma. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded. |
HCC study 9 (alcohol; HBV) / normal liver tissue
Relative Expression (log2-ratio):-3.69102Number of Samples:3 / 10
Experimental | HCC study 9 (alcohol; HBV) |
Liver tissue biopsy sample from patients with alcohol abuse and Hepatitis B infection related hepatocellular carcinoma (HCC) after resection. | |
Control | normal liver tissue |
Normal, non-tumor liver tissue. |
hepatoblastoma study 1 (mixed epithelial and mesenchymal) / normal liver tissue
Relative Expression (log2-ratio):-3.673235Number of Samples:4 / 5
Experimental | hepatoblastoma study 1 (mixed epithelial and mesenchymal) |
Liver tumor tissue samples from children with hepatoblastoma (mesenchymal type (MEM-HB); mixed epithelial and mesenchymal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group. | |
Control | normal liver tissue |
Normal liver tissue samples. |