TOP TEN perturbations for 38919_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38919_at
Selected probe(set): 206005_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38919_at (206005_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
male infertility study 1 (mJS2) / normal testicular lobules tissue (mJS10)
Relative Expression (log2-ratio):-3.7642536Number of Samples:7 / 8
Experimental | male infertility study 1 (mJS2) |
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2. | |
Control | normal testicular lobules tissue (mJS10) |
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10). |
male infertility study 1 (juvenile; Ad-) / normal testicular lobules tissue (mJS10)
Relative Expression (log2-ratio):-3.5379705Number of Samples:2 / 8
Experimental | male infertility study 1 (juvenile; Ad-) |
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained very low level of A-dark (Ad-) spermatogonial cells. | |
Control | normal testicular lobules tissue (mJS10) |
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10). |
male infertility study 1 (mJS3) / normal testicular lobules tissue (mJS10)
Relative Expression (log2-ratio):-3.0877647Number of Samples:3 / 8
Experimental | male infertility study 1 (mJS3) |
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained Sertoli cells but rarely spermatogonia. Tissue samples were classified based on modified Johnsen score (mJS) as mJS3. | |
Control | normal testicular lobules tissue (mJS10) |
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10). |
male infertility study 1 (mJS8) / male infertility study 1 (mJS2)
Relative Expression (log2-ratio):3.073042Number of Samples:7 / 7
Experimental | male infertility study 1 (mJS8) |
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained many early and elongated but only few mature spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS8. | |
Control | male infertility study 1 (mJS2) |
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2. |
male infertility study 1 (juvenile; Ad+) / normal testicular lobules tissue (mJS10)
Relative Expression (log2-ratio):-2.939478Number of Samples:5 / 8
Experimental | male infertility study 1 (juvenile; Ad+) |
Human testicular lobules biopsy samples isolated from prepubescent patients with undescended testes. Testes of these children contained typical level of A-dark (Ad+) spermatogonial cells. | |
Control | normal testicular lobules tissue (mJS10) |
Biopsies of human testicular lobules isolated from fertile vasectomized adult men with normal spermatogenesis. Histological analysis classified samples as mJS10 (modified Johnsen score 10). |
male infertility study 1 (mJS7) / male infertility study 1 (mJS2)
Relative Expression (log2-ratio):2.665182Number of Samples:4 / 7
Experimental | male infertility study 1 (mJS7) |
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained early but no late spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS7. | |
Control | male infertility study 1 (mJS2) |
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained almost exclusively Sertoli cells. Tissue samples were classified based on modified Johnsen score (mJS) as mJS2. |
male infertility study 1 (mJS8) / male infertility study 1 (mJS3)
Relative Expression (log2-ratio):2.396553Number of Samples:7 / 3
Experimental | male infertility study 1 (mJS8) |
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained many early and elongated but only few mature spermatids. Tissue samples were classified based on modified Johnsen score (mJS) as mJS8. | |
Control | male infertility study 1 (mJS3) |
Human testicular lobules biopsy samples isolated from adult infertile patients whose seminiferous tubules contained Sertoli cells but rarely spermatogonia. Tissue samples were classified based on modified Johnsen score (mJS) as mJS3. |
TGF-ß study 5 (late) / untreated A549 cell sample
Relative Expression (log2-ratio):2.1677952Number of Samples:3 / 3
Experimental | TGF-ß study 5 (late) |
Human A549 cells were treated with 5ng/ml porcine TGF-ß after serum-starving for 24h. Samples were taken 72 hours after TGF-ß treatment. | |
Control | untreated A549 cell sample |
A549 cells were grown for 24 hours. Samples were taken immediately before TGF-ß treatment. |
OVCAR-8 RIIB / OVCAR-8
Relative Expression (log2-ratio):-2.1355858Number of Samples:3 / 3
Experimental | OVCAR-8 RIIB |
Human metastatic cancer cell line derived from the ascites fluid from a cisplatin-resistant patient with carcinoma of the ovary. Stably transfected with the cAMP-dependent protein kinase (PKA) regulatory subunit gene for RIIβ. Parental cell line:: OVCAR-8 Cellosaurus code: | |
Control | OVCAR-8 |
Human metastatic cancer cell line derived from the ascites fluid from a cisplatin-resistant patient with carcinoma of the ovary. Synonyms:NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 Cellosaurus code: |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, synovial sarcoma, spindle cell; primary) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; primary)
Relative Expression (log2-ratio):2.0320644Number of Samples:6 / 2
Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, synovial sarcoma, spindle cell; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, synovial sarcoma, spindle cell of the soft tissue (subcutaneously implanted). | |
Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, leiomyosarcoma, NOS of the soft tissue (subcutaneously implanted). |