TOP TEN perturbations for 38987_at (Homo sapiens)
Organism: Homo sapiens
Gene: 38987_at
Selected probe(set): 201421_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 38987_at (201421_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
colorectal cancer study 33 (carcinoma; colonic mucosa) / adjacent colon mucosa sample
Relative Expression (log2-ratio):2.7634325Number of Samples:5 / 5
Experimental | colorectal cancer study 33 (carcinoma; colonic mucosa) |
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal carcinoma. | |
Control | adjacent colon mucosa sample |
Adjacent colon mucosa sample obtained by laser capture microdissection (LCM) from patients with colorectal cancer. |
colorectal cancer study 33 (carcinoma; colonic mucosa) / normal colon mucosa sample
Relative Expression (log2-ratio):2.7233915Number of Samples:5 / 5
Experimental | colorectal cancer study 33 (carcinoma; colonic mucosa) |
Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal carcinoma. | |
Control | normal colon mucosa sample |
Histopathological normal colon mucosa sample obtained by laser capture microdissection (LCM) from the distant normal colon of patients with colorectal cancer. |
T-cell activation study 1 / quiescent CD4+ T-cell sample
Relative Expression (log2-ratio):2.6653166Number of Samples:2 / 2
Experimental | T-cell activation study 1 |
CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors were activated with plate bound CD3 (1ug/ml) and soluble CD28 (50ng/ml) for 1 day. | |
Control | quiescent CD4+ T-cell sample |
Quiescent CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors. |
echinomycin study 1 / deferoxamine study 5
Relative Expression (log2-ratio):2.6641273Number of Samples:3 / 3
Experimental | echinomycin study 1 |
Echinomycin (100nM; 2h) treated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:--- | |
Control | deferoxamine study 5 |
Untreated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code: |
T-cell isolation study 11 / T-cell isolation study 6
Relative Expression (log2-ratio):-2.308216Number of Samples:2 / 2
Experimental | T-cell isolation study 11 |
CD4+ resting memory T-cell were isolated from peripheral blood buffy coat of healthy donors after storage for 24 hours at 20°C. The cell fraction was first enriched via density gradient centrifugation with LSM 1077 Ficoll and than FACS sorted as CD3+/CD4+/CD45RO+/CD45RA- population. | |
Control | T-cell isolation study 6 |
CD4+ resting memory T-cell were isolated from whole peripheral blood of healthy donors with no delay. The cell fraction was first enriched via density gradient centrifugation with LSM 1077 Ficoll and than FACS sorted as CD3+/CD4+/CD45RO+/CD45RA- population. |
tumor supernatant activation study 3 / memory T-cell activation study 1
Relative Expression (log2-ratio):-2.2675447Number of Samples:4 / 3
Experimental | tumor supernatant activation study 3 |
Memory (CD45RA-) CD4+ T cells isolated from peripheral blood of female healthy donors were incubated for 24 hours in 1:1 mix of tumor supernatant from primary invasive breast ductal carcinoma and X-VIVO 20 medium supplemented with antiCD3/CD28 beads, before harvest for RNA isolation. The tumor supernatant was prepared as followed: fresh surgical specimen was dissociated in X-VIVO 20 medium by GentleMACS dissociator and the resulting suspension was clarified by centrifugation for 15min at 13'000 g. ATC code:--- | |
Control | memory T-cell activation study 1 |
Memory (CD45RA-) CD4+ T-cells isolated from peripheral blood of healthy female donors were activated with anti-CD3/CD28 beads for 24hrs. |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, pleomorphic rhabdomyosarcoma, adult type; primary) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, malignant peripheral nerve sheath tumor; primary)
Relative Expression (log2-ratio):2.2079973Number of Samples:2 / 3
Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, pleomorphic rhabdomyosarcoma, adult type; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, pleomorphic rhabdomyosarcoma, adult type of the soft tissue (subcutaneously implanted). | |
Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, malignant peripheral nerve sheath tumor; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, malignant peripheral nerve sheath tumor of the soft tissue (subcutaneously implanted). |
colorectal cancer study 33 (carcinoma; colonic crypt) / adjacent colonic crypt epithelial cell sample
Relative Expression (log2-ratio):2.2018633Number of Samples:5 / 5
Experimental | colorectal cancer study 33 (carcinoma; colonic crypt) |
Colonic crypt epithelial cell samples obtained by laser capture microdissection (LCM) from patients with colorectal carcinoma. | |
Control | adjacent colonic crypt epithelial cell sample |
Adjacent colonic crypt epithelial cells obtained by laser capture microdissection (LCM) from patients with colorectal cancer. |
colorectal cancer study 33 (carcinoma; colonic crypt) / normal colonic crypt epithelial cell sample
Relative Expression (log2-ratio):2.181775Number of Samples:5 / 5
Experimental | colorectal cancer study 33 (carcinoma; colonic crypt) |
Colonic crypt epithelial cell samples obtained by laser capture microdissection (LCM) from patients with colorectal carcinoma. | |
Control | normal colonic crypt epithelial cell sample |
Histopathological normal colonic crypt epithelial cells obtained by laser capture microdissection (LCM) from the distant normal colon of patients with colorectal cancer. |
colorectal cancer study 43 (metastase; brain) / colorectal cancer study 43 (metastase; liver)
Relative Expression (log2-ratio):-2.1097555Number of Samples:2 / 25
Experimental | colorectal cancer study 43 (metastase; brain) |
Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma. | |
Control | colorectal cancer study 43 (metastase; liver) |
Metastatic tumor tissue obtained from the liver of patients with primary colon adenocarcinoma. |