TOP TEN perturbations for 39024_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39024_at
Selected probe(set): 210793_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39024_at (210793_s_at) across 6674 perturbations tested by GENEVESTIGATOR:

lactic acid study 1 (hypoxia) / untreated breast epithelial cell sample

Relative Expression (log2-ratio):-3.4254885
Number of Samples:3 / 3
Experimental lactic acid study 1 (hypoxia)
Breast epithelial cells exposed to 25mM lactic acid of pH6.7 and 2% hypoxia. ATC code:
Control untreated breast epithelial cell sample
Breast epithelial cells in control media under normoxia.

oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample

Relative Expression (log2-ratio):-3.158268
Number of Samples:3 / 3
Experimental oncolytic herpes simplex virus study 2
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control mock infected peripheral nerve sheath tumor (S462) cell sample
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours.

adefovir study 1 (50uM) / vehicle (DMSO) treated HepG2 sample

Relative Expression (log2-ratio):-3.0867233
Number of Samples:3 / 21
Experimental adefovir study 1 (50uM)
HepG2 cells treated with compound: adefovir (50uM; CAS no.:106941-25-7) for 24 hours. Adefovir is non-hepatotoxic. HepG2 cells were treated with the IC20 concentration measured after 24 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 sample
HepG2 cells treated with DMSO (0.5% v/v) as solvent control for 24 hours.

B-CLL study 11 (DMSO) / vehicle (DMSO) treated normal B-cell sample

Relative Expression (log2-ratio):-2.9744844
Number of Samples:4 / 4
Experimental B-CLL study 11 (DMSO)
Peripheral blood mononuclear cells (PBMCs) obtained from chronic lymphocytic leukemia (CLL) patients and in vitro treated with vehicle (DMSO) for 4 hours. PBMCs’ samples contained 90% CD19+ CD5+ B lineage CLL cells (B-CLL). Inclusion criteria: untreated CLL patients or at least 1 month after chemotherapy. Exclusion criteria: patients with active infections or other serious medical conditions or with white blood cell (WBC) counts of 15,000/l.
Control vehicle (DMSO) treated normal B-cell sample
MACS purified resting B-cells from healthy donor peripheral blood treated with vehicle (DMSO) for 4 hours.

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):2.957323
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

TNF-ɑ; TGF-ß2 study 1 (late) / TNF-ɑ; TGF-ß2 study 1 (early)

Relative Expression (log2-ratio):-2.8441277
Number of Samples:6 / 5
Experimental TNF-ɑ; TGF-ß2 study 1 (late)
ARPE-19 retina pigment epithelial cell samples treated with TNF-ɑ (10 ng/ml) and TGF-ß2 (5 ng/ml). Samples were taken 42 and 60 hours after treatment.
Control TNF-ɑ; TGF-ß2 study 1 (early)
ARPE-19 retina pigment epithelial cell samples treated with TNF-ɑ (10 ng/ml) and TGF-ß2 (5 ng/ml). Samples were taken 1 hour and 6 hours after treatment.

stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample

Relative Expression (log2-ratio):2.7782383
Number of Samples:2 / 3
Experimental stem cell differentiation study 41 (T3pi)
Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype.
Control undifferentiated hES-T3 cell sample
Undifferentiated human embryonic stem cells T3.

PCB153 study 1 (24h; 70uM) / PCB153 study 1 (30min; 70uM)

Relative Expression (log2-ratio):-2.7139034
Number of Samples:3 / 2
Experimental PCB153 study 1 (24h; 70uM)
HK-2 cell line (8th generation) were treated with 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB153) for 6 hours. Cells were grown in keratinocyte-serum free medium supplemented with 5ng/ml recombinant epidermal growth factor, 0.05mg/ml bovinepituitary extract and 1x penicillin-streptomycin. ATC code:---
Control PCB153 study 1 (30min; 70uM)
HK-2 cell line (8th generation) were treated with 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB153) for 30 minutes. Cells were grown in keratinocyte-serum free medium supplemented with 5ng/ml recombinant epidermal growth factor, 0.05mg/ml bovinepituitary extract and 1x penicillin-streptomycin. ATC code:---

PCB153 study 1 (24h; 70uM) / untreated HK-2 cell sample

Relative Expression (log2-ratio):-2.6355667
Number of Samples:3 / 4
Experimental PCB153 study 1 (24h; 70uM)
HK-2 cell line (8th generation) were treated with 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB153) for 6 hours. Cells were grown in keratinocyte-serum free medium supplemented with 5ng/ml recombinant epidermal growth factor, 0.05mg/ml bovinepituitary extract and 1x penicillin-streptomycin. ATC code:---
Control untreated HK-2 cell sample
HK-2 cell line (8th generation) grown in keratinocyte-serum free medium supplemented with 5ng/ml recombinant epidermal growth factor, 0.05mg/ml bovinepituitary extract and 1x penicillin-streptromycin.

epigallocatechin gallate study 1 (45840ng/ml) / vehicle (DME) treated bronchial epithelial cell sample

Relative Expression (log2-ratio):-2.6087332
Number of Samples:3 / 17
Experimental epigallocatechin gallate study 1 (45840ng/ml)
Bronchial epithelial cells (NHBE) treated with epigallocatechin gallate (45840ng/ml; vendor: Santa Cruz / catalog number: sc-200802 / catalog name: (-)-Epigallocatechin Gallate) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:---
Control vehicle (DME) treated bronchial epithelial cell sample
Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).