TOP TEN perturbations for 39032_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39032_at
Selected probe(set): 215111_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39032_at (215111_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
coronary artery disease study 2 / normal endothelial progenitor cell (133+) sample
Relative Expression (log2-ratio):4.1040945Number of Samples:9 / 3
Experimental | coronary artery disease study 2 |
133+ endothelial progenitor cells obtained from patients with coronary artery disease (CAD) prior to exercise. CAD patients were enrolled in a cardiac rehabilitation program. Medical management was stable for at least 1 month prior to program participation. Baseline testing was performed after an overnight fast (except for water). | |
Control | normal endothelial progenitor cell (133+) sample |
133+ endothelial progenitor cells obtained from healthy subjects. |
A. fumigatus study 1 / uninfected immature dendritic cell sample
Relative Expression (log2-ratio):3.9627695Number of Samples:2 / 2
Experimental | A. fumigatus study 1 |
5 x 106 immature dendritic cells were cultivated together with 5 x 106 A. fumigatus germ tubes for 6h until isolation of total RNA. | |
Control | uninfected immature dendritic cell sample |
5 x 106 immature dendritic cells were cultivated without fungi. |
cell cycle inhibition study 1 / untreated A2780 ovarian carcinoma cell sample
Relative Expression (log2-ratio):-3.9534836Number of Samples:3 / 3
Experimental | cell cycle inhibition study 1 |
Human ovarian carcinoma cells (A2780) exposed to 3 micromolar of a cell cycle inhibitor for 6hrs. | |
Control | untreated A2780 ovarian carcinoma cell sample |
Untreated human ovarian carcinoma cells (A2780). |
R547 study 1 (24h) / vehicle (DMSO) treated DU145 cell sample
Relative Expression (log2-ratio):-3.9154854Number of Samples:2 / 4
Experimental | R547 study 1 (24h) |
Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 24 hours at a 3xIC90 concentration of 5.1 μmol/L. ATC code:--- | |
Control | vehicle (DMSO) treated DU145 cell sample |
Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 24 hours. |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)
Relative Expression (log2-ratio):3.5359707Number of Samples:2 / 2
Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, leiomyosarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, clear cell sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. |
R547 study 1 (6h) / vehicle (DMSO) treated DU145 cell sample
Relative Expression (log2-ratio):-3.4999847Number of Samples:4 / 4
Experimental | R547 study 1 (6h) |
Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 6 hours at a 3xIC90 concentration of 5.1 μmol/L. ATC code:--- | |
Control | vehicle (DMSO) treated DU145 cell sample |
Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 6 hours. |
actinomycin D study 1 / mannitol treated A549 cell sample
Relative Expression (log2-ratio):-3.3316784Number of Samples:3 / 3
Experimental | actinomycin D study 1 |
A549 human lung cancer cells were seeded eights days prior to treatment of non-cycling plateau phase cultures with drug. At four hours prior to RNA isolation, actinomycin D (5 ug/mL final concentration) was added to the culture. ATC code: | |
Control | mannitol treated A549 cell sample |
A549 human lung cancer cells were seeded eights days prior to treatment of non-cycling plateau phase cultures with drug. At four hours prior to RNA isolation, mannitol (5% final concentration) was added to the culture. |
echinomycin study 1 / deferoxamine study 5
Relative Expression (log2-ratio):-3.2539797Number of Samples:3 / 3
Experimental | echinomycin study 1 |
Echinomycin (100nM; 2h) treated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:--- | |
Control | deferoxamine study 5 |
Untreated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code: |
rosiglitazone study 5 (late) / IL-4; GM-CSF study 1 (late)
Relative Expression (log2-ratio):3.1119976Number of Samples:6 / 6
Experimental | rosiglitazone study 5 (late) |
Monocytes, cultured with 2.5 uM rosiglitazone (RSG) and 500 U/ml IL-4 and 800 U/ml GM-CSF for 5 days. Cytokine treatment was repeated at day 3. ATC code: | |
Control | IL-4; GM-CSF study 1 (late) |
Monocytes, cultured with vehicle (DMSO/ethanol) and 500 U/ml IL-4 and 800 U/ml GM-CSF for 5 days. Cytokine treatment was repeated at day 3. |
rosiglitazone study 4 / vehicle (DMSO/EtOH)/ IL-4/ GM-CSF treated monocyte sample
Relative Expression (log2-ratio):3.0664282Number of Samples:3 / 3
Experimental | rosiglitazone study 4 |
Monocytes were cultured for 5 days with 500 U/ml IL-4 and 800 U/ml GM-CSF, cytokine treatment was repeated at day 3. Rosiglitazone (RSG; 2.5 uM) was added at the beginning of differentiation. ATC code: | |
Control | vehicle (DMSO/EtOH)/ IL-4/ GM-CSF treated monocyte sample |
Monocytes were cultured for 5 days with 500 U/ml IL-4 and 800 U/ml GM-CSF, cytokine treatment was repeated at day 3. Vehicle (DMSO/ethanol) was added at the beginning of differentiation. |