Organism: Homo sapiens
Gene: 39103_s_at
Selected probe(set): 213279_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39103_s_at (213279_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-3.3365583
Number of Samples:20 / 18

Experimental	esophageal adenocarcinoma study 1
	Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique.
Control	normal esophageal epithelium sample
	Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

Relative Expression (log2-ratio):-2.8147306
Number of Samples:8 / 18

Experimental	esophageal squamous cell carcinoma study 1
	Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy.
Control	normal esophageal epithelium sample
	Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

Relative Expression (log2-ratio):-2.7417898
Number of Samples:3 / 3

Experimental	wound healing study 2 (ex vivo; DMSO)
	Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing DMSO for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 1:1000 fold dilution of DMSO. The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin.
Control	normal skin tissue (ex vivo)
	Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.

Relative Expression (log2-ratio):-2.7337008
Number of Samples:2 / 10

Experimental	HCC study 9 (HBV; HCV)
	Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection.
Control	normal liver tissue
	Normal, non-tumor liver tissue.

Relative Expression (log2-ratio):-2.5433874
Number of Samples:3 / 3

Experimental	HIF-1a/HIF-2a depletion study 1 (hypoxia; HK2)
	Proximal tubule epithelial cell line HK-2 with shRNA-mediated stable knock-down of HIF-1a and HIF-2a (Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 2-alpha) 24 hours after treatment with hypoxia (20% O2). HK-2 cells were cultured in DMEM/F-12 supplemented with 10% fetal calf serum (FCS), 1% ITS, hydrocortisone, and antibiotics. The cells were incubated at 37 °C.
Control	HIF-1a/HIF-2a depletion study 1 (normoxia; AB81)
	Human podocyte cells AB81 with shRNA-mediated stable knock-down of HIF-1a and HIF-2a (Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 2-alpha) 24 hours after treatment with normoxia (20% O2). Conditionally immortalized human podocytes AB81 were cultured under permissive conditions (33 °C) in RPMI-1640 supplemented with 10% FBS, antibiotics, and 1% ITS. Differentiation was induced by thermoshift to 37 °C in 6-well plates.

Relative Expression (log2-ratio):-2.4678593
Number of Samples:17 / 18

Experimental	Barrett's esophagus study 3
	Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection.
Control	normal esophageal epithelium sample
	Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy.

Relative Expression (log2-ratio):2.3415565
Number of Samples:2 / 5

Experimental	connective/soft tissue cancer study 1 (PDX; connective and soft tissue, liposarcoma, well differentiated type; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, liposarcoma, well differentiated type of the soft tissue (subcutaneously implanted).
Control	connective/soft tissue cancer study 1 (PDX; connective and soft tissue, dedifferentiated liposarcoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, dedifferentiated liposarcoma of the soft tissue (subcutaneously implanted).

Relative Expression (log2-ratio):-2.2362652
Number of Samples:11 / 64

Experimental	Merkel cell carcinoma study 3 (metastatic)
	Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control	normal skin tissue
	Normal skin samples from healthy donors.

Relative Expression (log2-ratio):-2.2189074
Number of Samples:40 / 2

Experimental	melanoma study 34 (metastatic)
	Metastatic tumor tissue sample obtained from the patients with metastatic malignant melanoma of the skin. Metastatic samples composed of 22 macroscopic lymph node metastases, 16 subcutaneous metastases and 2 solid organ metastases (adrenal and brain).
Control	melanoma study 34 (in situ)
	Tumor tissue from the skin of patients with melanoma in situ.

Relative Expression (log2-ratio):2.140976
Number of Samples:3 / 3

Experimental	CD44s overexpr. study 1
	Human embryonic kidney cell line HEK-293 transfected with pcDNA3.1(-) vector containing codon-optimized human CD44 sequence for expression.
Control	normal HEK-293 cell sample
	Untransfected, native human embryonic kidney cell line HEK-293 cell samples.