TOP TEN perturbations for 39115_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39115_at
Selected probe(set): 203368_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39115_at (203368_at) across 6674 perturbations tested by GENEVESTIGATOR:

basal cell carcinoma study 3 / normal epidermal keratinocytes

Relative Expression (log2-ratio):-2.7035437
Number of Samples:4 / 2
Experimental basal cell carcinoma study 3
Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC).
Control normal epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2.

rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium) / focal segmental glomerulosclerosis study 9 (glomerulus)

Relative Expression (log2-ratio):-2.6841726
Number of Samples:21 / 10
Experimental rapidly progressive glomerulonephritis; ANCA-associated vasculitis study 5 (tubulointerstitium)
Tubulointerstitium tissue sample obtained by microdissection from kidney biopsy, from patients suffering from rapidly progressive glomerulonephritis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Donors were positive for ANCA-antibody. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.
Control focal segmental glomerulosclerosis study 9 (glomerulus)
Glomeruli tissue sample obtained by microdissection from kidney biopsy, from patients suffering from focal segmental glomerulosclerosis. Biopsy samples were obtained from the European Renal cDNA Bank-Kroener-Fresenius biopsy bank. All biopsies were stratified by a reference pathologist.

ovarian tumor study 16 / normal ovarian surface epithelial cell sample

Relative Expression (log2-ratio):2.127801
Number of Samples:3 / 5
Experimental ovarian tumor study 16
Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control normal ovarian surface epithelial cell sample
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

PCB153 study 1 (24h; 70uM) / untreated HK-2 cell sample

Relative Expression (log2-ratio):2.0065641
Number of Samples:3 / 4
Experimental PCB153 study 1 (24h; 70uM)
HK-2 cell line (8th generation) were treated with 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB153) for 6 hours. Cells were grown in keratinocyte-serum free medium supplemented with 5ng/ml recombinant epidermal growth factor, 0.05mg/ml bovinepituitary extract and 1x penicillin-streptomycin. ATC code:---
Control untreated HK-2 cell sample
HK-2 cell line (8th generation) grown in keratinocyte-serum free medium supplemented with 5ng/ml recombinant epidermal growth factor, 0.05mg/ml bovinepituitary extract and 1x penicillin-streptromycin.

PCB153 study 1 (24h; 70uM) / PCB153 study 1 (30min; 70uM)

Relative Expression (log2-ratio):1.9048872
Number of Samples:3 / 2
Experimental PCB153 study 1 (24h; 70uM)
HK-2 cell line (8th generation) were treated with 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB153) for 6 hours. Cells were grown in keratinocyte-serum free medium supplemented with 5ng/ml recombinant epidermal growth factor, 0.05mg/ml bovinepituitary extract and 1x penicillin-streptomycin. ATC code:---
Control PCB153 study 1 (30min; 70uM)
HK-2 cell line (8th generation) were treated with 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB153) for 30 minutes. Cells were grown in keratinocyte-serum free medium supplemented with 5ng/ml recombinant epidermal growth factor, 0.05mg/ml bovinepituitary extract and 1x penicillin-streptomycin. ATC code:---

HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)

Relative Expression (log2-ratio):1.7971344
Number of Samples:2 / 2
Experimental HIV-associated neurocognitive disorder study 7 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART).
Control HIV-associated neurocognitive disorder study 6 (normal)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART).

MCF-7.5C / MCF-7

Relative Expression (log2-ratio):-1.7676401
Number of Samples:3 / 4
Experimental MCF-7.5C
Human metastatic cancer cell line derived from the pleural effusion of a patient with adenocarcinoma of the breast. Long-term estrogen deprived breast cancer cells, which are resistant to estrogen-deprivation and therefore show an aromatase inhibitor resistantance. Parental cell line:: MCF-7 Synonyms:MCF-7 clone 5C; 5C; MCF-7:5C Cellosaurus code:
Control MCF-7
Human metastatic cancer cell line derived from the pleural effusion of a patient (69 years old, caucasian) with adenocarcinoma of the breast. Synonyms:MCF 7; MCF.7; MCF7; Michigan Cancer Foundation 7; ssMCF7; MCF7/WT; IBMF-7; MCF7-CTRL Cellosaurus code:

diabetes type 2 study 27 (LCM) / diabetes type 2 study 27 (enzymatic)

Relative Expression (log2-ratio):1.7438183
Number of Samples:34 / 19
Experimental diabetes type 2 study 27 (LCM)
Pancreatic islet samples obtained from type 2 diabetic (T2D) phenotyped pancreatectomized patients (PPP) and isolated by laser capture microdissection (LCM). Islets specimens were retrieved by LCM from snap-frozen surgical specimen from patients who underwent pancreatectomy for pancreatic diseases. Histopathology of the resected tissue did not reveal insulitis in any PPP. Patients age <18 years were excluded. Patients with type 2 diabetes had fasting glycemia ≥7.0 mmol/l; HbA1C ≥6.5% and history of diabetes for >1 year.
Control diabetes type 2 study 27 (enzymatic)
Pancreatic islet samples obtained from type 2 diabetic (T2D) patients and isolated by enzymatic digestion. Well-preserved islets were isolated by collagenase digestion of pancreas from brain-dead organ donors which suffered from type 2 diabetes. After 2±1 days of culture, islets were successfully hand-picked and processed for further analyses. Type 2 diabetes was diagnosed based on clinical history, treatment with glucose-lowering drugs, and lack of anti-GAD65 autoantibodies.

HIV-associated neurocognitive disorder study 3 (HIVE) / HIV-associated neurocognitive disorder study 2 (HIVE)

Relative Expression (log2-ratio):1.7132034
Number of Samples:2 / 2
Experimental HIV-associated neurocognitive disorder study 3 (HIVE)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with HIV encephalitis (HIVE). HIVE was limited to the basal ganglia. The patients did not receive any antiretroviral therapy (ART).
Control HIV-associated neurocognitive disorder study 2 (HIVE)
Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with HIV encephalitis (HIVE). The patients received an antiretroviral therapy (ART).

tunicamycin study 1 / vehicle (DMSO) treated B-cell-derived EBV-transformed lymphoblastoid cell sample

Relative Expression (log2-ratio):1.707799
Number of Samples:60 / 60
Experimental tunicamycin study 1
B-cell-derived EBV-transformed lymphoblastoid cells (derived from Coriell cell repository) from unrelated individuals (grandparents in the HapMap CEPH-Utah pedigrees) were treated with 4 ug/ml tunicamycin for 8 hours. Tunicamycin is a mixture of homologous nucleoside antibiotics inhibiting polyprenol-P HexNAc-1-P family of enzymes. Tunicamycin blocks N-linked glycosylation (N-glycans) induce unfolded protein response (UPR) leading to accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER). ATC code:---
Control vehicle (DMSO) treated B-cell-derived EBV-transformed lymphoblastoid cell sample
B-cell-derived EBV-transformed lymphoblastoid cells (derived from Coriell cell repository) from unrelated individuals (grandparents in the HapMap CEPH-Utah pedigrees) treated with vehicle DMSO for 8 hours.