TOP TEN perturbations for 39134_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39134_at
Selected probe(set): 202807_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39134_at (202807_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
esophageal adenocarcinoma study 1 / normal esophageal epithelium sample
Relative Expression (log2-ratio):-2.3742027Number of Samples:20 / 18
Experimental | esophageal adenocarcinoma study 1 |
Esophageal adenocarcinoma (EAC) samples of affected epithelium recovered by laser capture microdissection technique. | |
Control | normal esophageal epithelium sample |
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy. |
Barrett's esophagus study 3 / normal esophageal epithelium sample
Relative Expression (log2-ratio):-2.2629757Number of Samples:17 / 18
Experimental | Barrett's esophagus study 3 |
Esophageal epithelium samples from areas with Barrett's esophagus metaplasia which were recovered by laser capture microdissection. | |
Control | normal esophageal epithelium sample |
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy. |
esophageal squamous cell carcinoma study 1 / normal esophageal epithelium sample
Relative Expression (log2-ratio):-2.200306Number of Samples:8 / 18
Experimental | esophageal squamous cell carcinoma study 1 |
Esophageal squamous cell carcinoma (ESCC) biopsy samples from chemotherapy-naive patients with histological grading G1 (well differentiated) and UICC stage II and III, which undergone esophagectomy. | |
Control | normal esophageal epithelium sample |
Histologically normal esophageal squamous cell epithelium biopsy samples from patients that were investigated for esophageal pain, but diagnosed as healthy. |
T-cell isolation study 11 / T-cell isolation study 6
Relative Expression (log2-ratio):2.0294256Number of Samples:2 / 2
Experimental | T-cell isolation study 11 |
CD4+ resting memory T-cell were isolated from peripheral blood buffy coat of healthy donors after storage for 24 hours at 20°C. The cell fraction was first enriched via density gradient centrifugation with LSM 1077 Ficoll and than FACS sorted as CD3+/CD4+/CD45RO+/CD45RA- population. | |
Control | T-cell isolation study 6 |
CD4+ resting memory T-cell were isolated from whole peripheral blood of healthy donors with no delay. The cell fraction was first enriched via density gradient centrifugation with LSM 1077 Ficoll and than FACS sorted as CD3+/CD4+/CD45RO+/CD45RA- population. |
rheumatoid arthritis study 31 / TNF-ɑ study 20
Relative Expression (log2-ratio):-1.9819345Number of Samples:4 / 3
Experimental | rheumatoid arthritis study 31 |
Monocyte samples isolated from patients with rheumatoid arthritis (RA). Monocytes from whole blood were depleted from granulocytes by CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. Patients fulfilled the revised American College of Rheumatology criteria (ACR) for RA. | |
Control | TNF-ɑ study 20 |
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml TNFα in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |
TNF-ɑ study 20 / normal monocyte sample
Relative Expression (log2-ratio):1.7793131Number of Samples:3 / 7
Experimental | TNF-ɑ study 20 |
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml TNFα in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. | |
Control | normal monocyte sample |
Monocyte samples isolated from healthy subjects. Peripheral blood monocytes were isolated immediately after drawing blood by depletion from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocyte by CD14 labeling. |
Sjogren's syndrome study 1 (advanced) / normal minor salivary gland tissue
Relative Expression (log2-ratio):-1.505394Number of Samples:2 / 4
Experimental | Sjogren's syndrome study 1 (advanced) |
Whole minor salivary gland samples of patients with advanced Sjogren's syndrome. | |
Control | normal minor salivary gland tissue |
Whole minor salivary gland samples from non-Sjogren's syndrome control subjects. |
pediatric meningococcal sepsis study 1 (72h; blood) / normal blood sample
Relative Expression (log2-ratio):1.5042944Number of Samples:2 / 3
Experimental | pediatric meningococcal sepsis study 1 (72h; blood) |
Blood samples collected from children with (suspected) meningococcal sepsis 72 hours after admission to the pediatric intensive care unit (PICU). | |
Control | normal blood sample |
Normal blood samples collected from healthy children admitted for elective minor non-infectious surgery or MRI. |
glioma study 17 (glioblastoma; unsorted) / non-tumor cortical tissue
Relative Expression (log2-ratio):1.4774904Number of Samples:2 / 4
Experimental | glioma study 17 (glioblastoma; unsorted) |
Brain cells isolated from high grade glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation. | |
Control | non-tumor cortical tissue |
Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses. |
renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue (fetal)
Relative Expression (log2-ratio):1.4674616Number of Samples:4 / 2
Experimental | renal cell carcinoma study 6 (chromophobe type) |
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC). | |
Control | normal kidney tissue (fetal) |
Normal fetal kidney tissue samples. |