Organism: Homo sapiens
Gene: 39135_at
Selected probe(set): 212856_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39135_at (212856_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-3.130001
Number of Samples:4 / 6

Experimental	F. tularensis study 1 (tularensis Schu S4)
	Peripheral blood monocytes infected with the Schu S4 isolate of Francisella tularensis (100 MOI) for 24 hours.
Control	uninfected peripheral blood monocyte sample
	Peripheral blood monocytes uninfected.

Relative Expression (log2-ratio):-2.999795
Number of Samples:4 / 4

Experimental	lung cancer study 1 (PDX; pseudosarcomatous carcinoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary pseudosarcomatous carcinoma of the lung (subcutaneously implanted).
Control	lung cancer study 1 (PDX; adenosquamous carcinoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenosquamous carcinoma of the lung (subcutaneously implanted).

Relative Expression (log2-ratio):-2.8848715
Number of Samples:5 / 7

Experimental	E. coli study 2
	Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli.
Control	unstimulated, normal monocyte-derived macrophage sample
	Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated.

Relative Expression (log2-ratio):-2.6712608
Number of Samples:43 / 4

Experimental	adrenal gland cancer study 4
	Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control	normal adrenal cortex tissue
	Histological normal adrenal gland cortical tissue samples derived after autopsy.

Relative Expression (log2-ratio):-2.5377188
Number of Samples:31 / 10

Experimental	adrenal gland cancer study 2
	Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma.
Control	normal adrenal cortex tissue
	Unaffected adrenal cortex tissue from control objects.

Relative Expression (log2-ratio):2.5355911
Number of Samples:3 / 3

Experimental	polyamide study 1 (mismatch)
	Human non-small cell bronchoepithelial carcinoma cell line A549 grown in F12-K medium supplemented with 10% FBS and 4mM penicillin and streptomycin. After 24 hours the medium was replaced with F12-K containing 10% CT-FBS, 4mM penicillin/streptomycin and a mismatched synthetic DNA-binding polyamide (normally targeting the consensus sequence of the glucocorticoid receptor element and binding the glucocorticoid-induced zipper GILZ). After 48 hours 10nM dexamethasone was added to the cell culture. Samples were taken after additional 6 hours.
Control	mifepristone study 4
	Human non-small cell bronchoepithelial carcinoma cell line A549 grown in F12-K medium supplemented with 10% FBS and 4mM penicillin and streptomycin. After 24 hours the medium was replaced with F12-K containing 10% CT-FBS, 4mM penicillin/streptomycin and 3µM of the glucocorticoid receptor antagonist mifepristone. After 48 hours 10nM dexamethasone was added to the cell culture. Samples were taken after additional 6 hours. ATC code:

Relative Expression (log2-ratio):2.5263824
Number of Samples:3 / 3

Experimental	polyamide study 1 (mismatch)
	Human non-small cell bronchoepithelial carcinoma cell line A549 grown in F12-K medium supplemented with 10% FBS and 4mM penicillin and streptomycin. After 24 hours the medium was replaced with F12-K containing 10% CT-FBS, 4mM penicillin/streptomycin and a mismatched synthetic DNA-binding polyamide (normally targeting the consensus sequence of the glucocorticoid receptor element and binding the glucocorticoid-induced zipper GILZ). After 48 hours 10nM dexamethasone was added to the cell culture. Samples were taken after additional 6 hours.
Control	vehicle (medium) treated A549 cell sample
	Human non-small cell bronchoepithelial carcinoma cell line A549 grown in F12-K medium supplemented with 10% FBS and 4mM penicillin and streptomycin. After 24 hours the medium was replaced with F12-K containing 10% CT-FBS and 4mM penicillin/streptomycin. Samples were taken after additional 56 hours.

Relative Expression (log2-ratio):-2.440507
Number of Samples:3 / 3

Experimental	heat shock study 1 (LPS)
	Cultured THP-1 mononuclear cells were treated with heat shock (43°C; 1h) and lipopolysaccharide (1ug/ml; 4h).
Control	untreated THP-1 cell sample
	Cultured THP-1 mononuclear cells were cultured in basal growth media at 37°C.

Relative Expression (log2-ratio):-2.3238745
Number of Samples:12 / 16

Experimental	E. coli study 1
	Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli.
Control	unstimulated, normal monocyte-derived macrophage sample
	Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated.

Relative Expression (log2-ratio):-2.2126083
Number of Samples:2 / 2

Experimental	IFN-g; LPS study 1
	Monocytes LPS/IFN-g activated for 30h.
Control	normal resting monocyte sample
	Monocytes resting for 30h.