TOP TEN perturbations for 39136_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39136_at
Selected probe(set): 202696_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39136_at (202696_at) across 6674 perturbations tested by GENEVESTIGATOR:
brefeldin A study 1 (0.5ug/ml; p53HCT116) / untreated p53HCT116 cell sample
Relative Expression (log2-ratio):2.372323Number of Samples:2 / 3
Experimental | brefeldin A study 1 (0.5ug/ml; p53HCT116) |
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated p53HCT116 cell sample |
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) / ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary)
Relative Expression (log2-ratio):-2.354128Number of Samples:2 / 2
Experimental | ovarian tumor study 30 (PDX; transitional cell carcinoma, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary transitional cell carcinoma, NOS of the ovary (subcutaneously implanted). | |
Control | ovarian tumor study 30 (PDX; mixed tumor, malignant, NOS; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary mixed tumor, malignant, NOS of the ovary (subcutaneously implanted). |
atopic dermatitis study 21 (lesional; whole skin) / normal skin tissue
Relative Expression (log2-ratio):2.2776175Number of Samples:5 / 6
Experimental | atopic dermatitis study 21 (lesional; whole skin) |
Lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %. | |
Control | normal skin tissue |
Full thickness skin samples isolated from healthy subjects by laser capture microdissection. |
brefeldin A study 1 (0.5ug/ml; HCT 116) / untreated HCT 116 cell sample
Relative Expression (log2-ratio):2.248455Number of Samples:3 / 3
Experimental | brefeldin A study 1 (0.5ug/ml; HCT 116) |
Human colon carcinoma cell line HCT116 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated HCT 116 cell sample |
Human colon carcinoma cell line HCT116 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
brefeldin A study 1 (0.5ug/ml; HCT 116 DICER1(-/-)) / untreated HCT 116 DICER1(-/-) cell sample
Relative Expression (log2-ratio):2.0976486Number of Samples:3 / 3
Experimental | brefeldin A study 1 (0.5ug/ml; HCT 116 DICER1(-/-)) |
Derived human colon carcinoma cell line HCT 116 DICER1(-/-) with knockout DICER gene in exon 5 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated HCT 116 DICER1(-/-) cell sample |
Derived human colon carcinoma cell line HCT 116 DICER1(-/-) with knockout DICER gene in exon 5 by was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
chondrocyte maturation study 1 (proliferative zone) / chondrocyte maturation study 1 (pre-hypertrophic zone)
Relative Expression (log2-ratio):2.0825691Number of Samples:2 / 2
Experimental | chondrocyte maturation study 1 (proliferative zone) |
Populations of cells corresponding to the proliferative zone of growth plate were isolated by laser capture microdissection. The beginning of the proliferative zone was identified as the proliferative zone/reserve zone border. Cells from here to where the flattened chondrocytes first start to increase in size were collected. Since the columnar region of the growth plate is a continuum and has no distinct boundaries, each fraction is enriched for but does not exclusively contain cells of the target zone. The distal femoral growth plate was used in this study. | |
Control | chondrocyte maturation study 1 (pre-hypertrophic zone) |
Populations of cells corresponding to the pre-hypertrophic zone of growth plate were isolated by laser capture microdissection. The region between the proliferative and hypertrophic zones was designated as the pre-hypertrophic zone and dissected. Since the columnar region of the growth plate is a continuum and has no distinct boundaries, each fraction is enriched for but does not exclusively contain cells of the target zone. The distal femoral growth plate was used in this study. |
oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample
Relative Expression (log2-ratio):-2.074606Number of Samples:3 / 3
Experimental | oncolytic herpes simplex virus study 2 |
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours. | |
Control | mock infected peripheral nerve sheath tumor (S462) cell sample |
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours. |
TNF-ɑ study 20 / normal monocyte sample
Relative Expression (log2-ratio):2.0300846Number of Samples:3 / 7
Experimental | TNF-ɑ study 20 |
Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml TNFα in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. | |
Control | normal monocyte sample |
Monocyte samples isolated from healthy subjects. Peripheral blood monocytes were isolated immediately after drawing blood by depletion from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocyte by CD14 labeling. |
pancreatic cancer study 3 (ipmn) / normal pancreas tissue
Relative Expression (log2-ratio):2.029377Number of Samples:3 / 6
Experimental | pancreatic cancer study 3 (ipmn) |
Intraductal papillary mucinous neoplasm from patients with pancreatic cancer. | |
Control | normal pancreas tissue |
Normal human pancreatic tissue. |
engineered skin substitute study 2 (late) / engineered skin substitute study 1 (late)
Relative Expression (log2-ratio):-1.95432Number of Samples:5 / 3
Experimental | engineered skin substitute study 2 (late) |
Human skin substitutes tissue samples collected after 42 and 56 days after transplantation to athymic mice. | |
Control | engineered skin substitute study 1 (late) |
Human skin substitutes tissue samples collected after 14 days in culture. |