TOP TEN perturbations for 39158_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39158_at
Selected probe(set): 204998_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39158_at (204998_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
rheumatoid arthritis study 31 / TNF-ɑ study 20
Relative Expression (log2-ratio):-3.6076336Number of Samples:4 / 3
| Experimental | rheumatoid arthritis study 31 |
| Monocyte samples isolated from patients with rheumatoid arthritis (RA). Monocytes from whole blood were depleted from granulocytes by CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. Patients fulfilled the revised American College of Rheumatology criteria (ACR) for RA. | |
| Control | TNF-ɑ study 20 |
| Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml TNFα in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |
HCC study 18 (very advanced) / normal liver tissue
Relative Expression (log2-ratio):-3.4401274Number of Samples:3 / 10
| Experimental | HCC study 18 (very advanced) |
| Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded. | |
| Control | normal liver tissue |
| Normal liver tissue samples obtained from the healthy livers of patients undergoing resection for hepatic hemangioma, focal nodular hyperplasia, adenoma/cystadenoma, neuroendocrine tumor, and living donor liver transplantation. |
HCC study 18 (very advanced) / dysplastic liver nodule study 1
Relative Expression (log2-ratio):-3.3725033Number of Samples:3 / 17
| Experimental | HCC study 18 (very advanced) |
| Tumor tissue samples obtained from liver of patients with very advanced hepatocellular carcinoma (HCC) undergoing resection or liver transplantation. Very advanced HCC cases included moderately to poorly differentiated tumors with macrovascular invasion or diffuse liver involvement. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded. | |
| Control | dysplastic liver nodule study 1 |
| Dysplastic nodule tissue samples obtained from liver of HCV infected patients undergoing resection or liver transplantation. Patients positive for HBV markers, with history of alcohol consumption, nonalcoholic steatohepatitis, hemochromatosis, other chronic liver diseases or prior locoregional treatment were excluded. |
B-cell activation study 1 / unstimulated B-cell sample
Relative Expression (log2-ratio):3.1153593Number of Samples:4 / 4
| Experimental | B-cell activation study 1 |
| Tonsillar B-cell samples stimulated with 10 µg/mL anti-CD40 antibody and 100 U/mL recombinant human IL-4. Cells were cultured under TH2-skewing conditions for 24 hours. | |
| Control | unstimulated B-cell sample |
| Unstimulated tonsillar B-cells cultured for 24 hours. |
TNF-ɑ study 20 / normal monocyte sample
Relative Expression (log2-ratio):3.0800104Number of Samples:3 / 7
| Experimental | TNF-ɑ study 20 |
| Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml TNFα in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. | |
| Control | normal monocyte sample |
| Monocyte samples isolated from healthy subjects. Peripheral blood monocytes were isolated immediately after drawing blood by depletion from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocyte by CD14 labeling. |
rheumatoid arthritis study 31 / IFNa-2a study 1
Relative Expression (log2-ratio):-3.0272512Number of Samples:4 / 7
| Experimental | rheumatoid arthritis study 31 |
| Monocyte samples isolated from patients with rheumatoid arthritis (RA). Monocytes from whole blood were depleted from granulocytes by CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. Patients fulfilled the revised American College of Rheumatology criteria (ACR) for RA. | |
| Control | IFNa-2a study 1 |
| Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml IFNα2a in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |
Merkel cell carcinoma study 3 (primary) / normal skin tissue
Relative Expression (log2-ratio):2.8391962Number of Samples:19 / 64
| Experimental | Merkel cell carcinoma study 3 (primary) |
| Primary tumor tissue from the skin of patients with Merkel cell carcinoma. | |
| Control | normal skin tissue |
| Normal skin samples from healthy donors. |
TNF-ɑ study 20 / unstimulated monocyte sample
Relative Expression (log2-ratio):2.7584524Number of Samples:3 / 11
| Experimental | TNF-ɑ study 20 |
| Monocyte samples isolated from healthy donors and stimulated in vitro by 100 ng/ml TNFα in whole blood for 1.5 hour. Following stimulation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. | |
| Control | unstimulated monocyte sample |
| Monocyte samples isolated from healthy donors and incubated in whole blood for 1.5 hour without any stimulation. Following incubation, monocytes were depleted from granulocytes using CD15 MACS beads, and afterwards they were sorted from remaining peripheral blood leukocytes by CD14 labeling. |
Merkel cell carcinoma study 3 (primary) / basal cell carcinoma study 2
Relative Expression (log2-ratio):2.6645536Number of Samples:19 / 2
| Experimental | Merkel cell carcinoma study 3 (primary) |
| Primary tumor tissue from the skin of patients with Merkel cell carcinoma. | |
| Control | basal cell carcinoma study 2 |
| Primary tumor tissue from the skin of patients with basal cell carcinoma (BCC). |
glioma study 17 (glioblastoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)
Relative Expression (log2-ratio):2.6364937Number of Samples:3 / 3
| Experimental | glioma study 17 (glioblastoma; A2B5+) |
| Oligodendrocyte progenitor cells (OPC) isolated from high grade glioblastoma (grade IV). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 66 ± 5 years old males. | |
| Control | non-tumor oligodendrocyte progenitor cell sample (cortex) |
| Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. |
Organism: Homo sapiens
Gene: 39158_at
Selected probe(set): 230938_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39158_at (230938_x_at) across 6674 perturbations tested by GENEVESTIGATOR:
E. coli study 2 / unstimulated, normal monocyte-derived macrophage sample
Relative Expression (log2-ratio):1.9293251Number of Samples:5 / 7
| Experimental | E. coli study 2 |
| Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli. | |
| Control | unstimulated, normal monocyte-derived macrophage sample |
| Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated. |
HCC study 23 (portal vein infiltration) / adjacent liver tissue
Relative Expression (log2-ratio):-1.7757559Number of Samples:3 / 10
| Experimental | HCC study 23 (portal vein infiltration) |
| Tumor liver tissue samples derived from patients with hepatocellular carcinoma (HCC) with portal vein infiltration. Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai. | |
| Control | adjacent liver tissue |
| Normal adjacent liver tissue samples derived from patients with hepatocellular carcinoma (HCC). Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai. |
E. coli study 1 / unstimulated, normal monocyte-derived macrophage sample
Relative Expression (log2-ratio):1.3832054Number of Samples:12 / 16
| Experimental | E. coli study 1 |
| Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli. | |
| Control | unstimulated, normal monocyte-derived macrophage sample |
| Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated. |
glioma study 17 ( small cell glioblastoma; unsorted) / non-tumor cortical tissue
Relative Expression (log2-ratio):-1.2405014Number of Samples:2 / 4
| Experimental | glioma study 17 ( small cell glioblastoma; unsorted) |
| Brain cells isolated from high grade small cell glioblastoma (grade IV). Tumor tissue was dissociated using enzymatic treatment and all cells were used for RNA isolation. Patients were 56 ± 3 years old males. | |
| Control | non-tumor cortical tissue |
| Cortical tissue obtained from patients with epilepsy, but without any manifested brain cancer. The tissue was dissociated using enzymatic treatment, but all brain cell types were used for analyses. |
atopic dermatitis study 12 (lesional; adults) / atopic dermatitis study 12 (lesional; children)
Relative Expression (log2-ratio):1.2246294Number of Samples:20 / 18
| Experimental | atopic dermatitis study 12 (lesional; adults) |
| Lesional skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis. | |
| Control | atopic dermatitis study 12 (lesional; children) |
| Lesional popliteal skin biopsy samples from pediatric patients (age range 3 months-5 years) with early-onset atopic dermatitis. All biopsy specimens were from chronic lesions present for more than 72 hours. All patients had moderate-to-severe disease with recent-onset (within the previous 6 months). Systemic immunosuppressants within the past 4 weeks, topical steroids or immunomodulators within 1 week, or moisturizers within 12 hours before evaluation were restricted. Patients with active skin infections were excluded. |
glioma study 17 (astrocytoma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)
Relative Expression (log2-ratio):-1.1707144Number of Samples:3 / 3
| Experimental | glioma study 17 (astrocytoma; A2B5+) |
| Oligodendrocyte progenitor cells (OPC) isolated from low grade astrocytoma (grade II). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 36 ± 7 years old. | |
| Control | non-tumor oligodendrocyte progenitor cell sample (cortex) |
| Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. |
atopic dermatitis study 12 (non-lesional; adults) / atopic dermatitis study 12 (non-lesional; children)
Relative Expression (log2-ratio):1.1482306Number of Samples:20 / 19
| Experimental | atopic dermatitis study 12 (non-lesional; adults) |
| Unaffected skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis. | |
| Control | atopic dermatitis study 12 (non-lesional; children) |
| Unaffected buttock skin biopsy samples from pediatric patients (age range 3 months-5 years) with early-onset atopic dermatitis. All patients had moderate-to-severe disease (SCORAD score: mean, 57.8; range, 33-84) with recent-onset (within the previous 6 months). Systemic immunosuppressants within the past 4 weeks, topical steroids or immunomodulators within 1 week, or moisturizers within 12 hours before evaluation were restricted. Patients with active skin infections were excluded. |
HCC study 23 (portal vein infiltration) / HCC study 23 (no portal vein infiltration)
Relative Expression (log2-ratio):-1.1269608Number of Samples:3 / 7
| Experimental | HCC study 23 (portal vein infiltration) |
| Tumor liver tissue samples derived from patients with hepatocellular carcinoma (HCC) with portal vein infiltration. Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai. | |
| Control | HCC study 23 (no portal vein infiltration) |
| Tumor liver tissue samples derived from patients with hepatocellular carcinoma (HCC) without portal vein infiltration. Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai. |
atopic dermatitis study 12 (lesional; adults) / normal skin tissue (adults)
Relative Expression (log2-ratio):1.1062832Number of Samples:20 / 11
| Experimental | atopic dermatitis study 12 (lesional; adults) |
| Lesional skin biopsy samples from adult patients (age range 18-73 years) with long-standing atopic dermatitis. | |
| Control | normal skin tissue (adults) |
| Skin biopsy samples from healthy adults (age range 38–57 years). |
hepatoblastoma study 1 (embryonal) / normal liver tissue
Relative Expression (log2-ratio):-1.073863Number of Samples:7 / 5
| Experimental | hepatoblastoma study 1 (embryonal) |
| Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); embryonal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group. | |
| Control | normal liver tissue |
| Normal liver tissue samples. |