TOP TEN perturbations for 39190_s_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39190_s_at
Selected probe(set): 226737_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39190_s_at (226737_at) across 6431 perturbations tested by GENEVESTIGATOR:
breast cancer study 42 (metastase; liver) / breast cancer study 42 (metastase; chest wall)
Relative Expression (log2-ratio):2.0933247Number of Samples:3 / 2
| Experimental | breast cancer study 42 (metastase; liver) |
| Metastatic tumor tissue obtained from the liver of patients with primary breast adenocarcinoma. | |
| Control | breast cancer study 42 (metastase; chest wall) |
| Metastatic tumor tissue obtained from the chest wall of patients with primary breast adenocarcinoma. |
breast cancer study 42 (metastase; lymph node) / breast cancer study 42 (metastase; chest wall)
Relative Expression (log2-ratio):1.513627Number of Samples:7 / 2
| Experimental | breast cancer study 42 (metastase; lymph node) |
| Metastatic tumor tissue obtained from the lymph node of patients with primary breast adenocarcinoma. | |
| Control | breast cancer study 42 (metastase; chest wall) |
| Metastatic tumor tissue obtained from the chest wall of patients with primary breast adenocarcinoma. |
HCC study 23 (portal vein infiltration) / adjacent liver tissue
Relative Expression (log2-ratio):-1.4462738Number of Samples:3 / 10
| Experimental | HCC study 23 (portal vein infiltration) |
| Tumor liver tissue samples derived from patients with hepatocellular carcinoma (HCC) with portal vein infiltration. Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai. | |
| Control | adjacent liver tissue |
| Normal adjacent liver tissue samples derived from patients with hepatocellular carcinoma (HCC). Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai. |
estradiol study 17 (1nM; ERa) / control virus infected, estradiol treated MDA Mb231 cell sample
Relative Expression (log2-ratio):1.2654095Number of Samples:6 / 12
| Experimental | estradiol study 17 (1nM; ERa) |
| MDA Mb231 cells were infected with a recombinant adenovirus bearing a cDNA for ERalpha in medium without phenol red and containing 10% CD-FBS for 48h. Cells were then treated with 1 nM estradiol-17beta for 6 hours. ATC code: | |
| Control | control virus infected, estradiol treated MDA Mb231 cell sample |
| Empty vector transfected MDA Mb231 cells were treated with 1 nM estradiol-17beta for 6h. Cells were infected with a recombinant adenovirus bearing no cDNA (CMV) in medium without phenol red and treated 24 hours later. ATC code: |
hepatoblastoma study 1 (crowded fetal) / hepatoblastoma study 1 (embryonal)
Relative Expression (log2-ratio):1.2297211Number of Samples:3 / 7
| Experimental | hepatoblastoma study 1 (crowded fetal) |
| Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); crowded fetal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group. | |
| Control | hepatoblastoma study 1 (embryonal) |
| Liver tumor tissue samples from children with hepatoblastoma (epithelial type (E-HB); embryonal subtype). Tumors were integrase interactor 1–negative (INI1 or SMARCB1) as recommended by the International ConsensusHBClassification group. |
retina pigment epithelium study 1 (adult) / retina pigment epithelium study 1 (fetal)
Relative Expression (log2-ratio):1.1880226Number of Samples:2 / 6
| Experimental | retina pigment epithelium study 1 (adult) |
| Postmortem human native retina pigment epithelium samples from adult individuals. | |
| Control | retina pigment epithelium study 1 (fetal) |
| Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18. |
CVID study 1 (anergic B-cell) / rheumatoid arthritis study 18 (anergic B-cell)
Relative Expression (log2-ratio):-1.1671152Number of Samples:3 / 2
| Experimental | CVID study 1 (anergic B-cell) |
| Anergic naive B-cells (CD19+,CD10-, CD21-/lo, CD27-) from patients suffering from Common Variable Immunodeficiency Disease (CVID). | |
| Control | rheumatoid arthritis study 18 (anergic B-cell) |
| Anergic naive B-cells (CD19+,CD10-, CD21-/lo, CD27-) from patients suffering from rheumatoid arthritis (RA) affecting multiple (subj.ID:19) or all (subj.ID:1) joints. |
phenobarbital study 3 (10000uM) / vehicle (medium) treated hepatocyte sample
Relative Expression (log2-ratio):-1.1646118Number of Samples:2 / 2
| Experimental | phenobarbital study 3 (10000uM) |
| Hepatocytes treated with compound: phenobarbital (10000uM; CHEMBL40) for 24 hours. ATC code: | |
| Control | vehicle (medium) treated hepatocyte sample |
| Hepatocytes treated with vehicle (medium) for 24 hours. |
glioma study 17 (oligodendroglioma; A2B5+) / non-tumor oligodendrocyte progenitor cell sample (cortex)
Relative Expression (log2-ratio):-1.128089Number of Samples:3 / 3
| Experimental | glioma study 17 (oligodendroglioma; A2B5+) |
| Oligodendrocyte progenitor cells (OPC) isolated from low grade oligodendroglioma (grade II). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 39 ± 9 years old. | |
| Control | non-tumor oligodendrocyte progenitor cell sample (cortex) |
| Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. |
EBNA2 overexpr. study 1 (24h) / control virus transfected EREB2-5 cell sample (24h)
Relative Expression (log2-ratio):-1.1181269Number of Samples:3 / 3
| Experimental | EBNA2 overexpr. study 1 (24h) |
| EREB2-5 cell line stably transfected with the chimeric Epstein-Barr virus-encoded nuclear antigen 2 (EBNA2) and control expression plasmid coding for bacterial chloramphenicol acetyltransferase (CAT) gene and . CAT was used as a negative control. Briefly, before the CAT and EBNA2 induction, cells were maintained in RPMI media and deprived of estrogen for 3 days before doxycycline and estrogen was added. Expression of EBNA2 was induced after addition of estrogen and expression of CAT was induced by the addition of doxycycline to a final concentration of 100 ng/mL medium. Doxycycline induced cells were harvested 24 hours after induction. Because EBNA2 is essential for the proliferation of EBV-infected cells, EREB2-5 cells grow only in the presence of estrogen. Before the preparation of RNA, NGFR cells were purified by MACS separation to enrich the cells with a transcriptional response to doxycycline. | |
| Control | control virus transfected EREB2-5 cell sample (24h) |
| EREB2-5 cell line stably transfected with control expression plasmid coding for bacterial chloramphenicol acetyltransferase (CAT) gene. CAT was used as a negative control. Briefly, before the CAT induction, cells were maintained in RPMI media and deprived of estrogen for 3 days before doxycycline was added. Expression of CAT was induced by the addition of doxycycline to a final concentration of 100 ng/mL medium. Doxycycline induced cells were harvested 24 hours after induction. Estrogen withdrawal leads to the inactivation of EBNA2, resulting in cell cycle arrest. Before the preparation of RNA, NGFR cells were purified by MACS separation to enrich the cells with a transcriptional response to doxycycline. |