Organism: Homo sapiens
Gene: 39224_at
Selected probe(set): 213618_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39224_at (213618_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-6.609165
Number of Samples:2 / 3

Experimental	CNS cancer study 1 (PDX; glioma, malignant, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioma, malignant, NOS of the central nervous system (subcutaneously implanted).
Control	CNS cancer study 1 (PDX; glioblastoma, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioblastoma, NOS of the central nervous system (subcutaneously implanted).

Relative Expression (log2-ratio):-5.0570135
Number of Samples:2 / 2

Experimental	CNS cancer study 1 (PDX; glioma, malignant, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioma, malignant, NOS of the central nervous system (subcutaneously implanted).
Control	CNS cancer study 1 (PDX; ependymoma, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary ependymoma, NOS of the central nervous system (subcutaneously implanted).

Relative Expression (log2-ratio):4.5382843
Number of Samples:10 / 10

Experimental	ZSTK474 inhibitor (10uM); GM-CSF (1ng/ml) study 1
	Primary neutrophils isolated from blood samples of healthy volunteers purified over discontinuous plasma-percoll gradients. Neutrophils were treated with pan phosphoinositide 3-kinase (PI3K) inhibitor ZSTK474 (10uM) and granulocyte macrophage-colony stimulating factor (rhGM-CSF; 1ng/ml) for 6h. ATC code:---
Control	ZSTK474 study 1 (10uM)
	Primary neutrophils isolated from blood samples of healthy volunteers purified over discontinuous plasma-percoll gradients. Neutrophils were treated with 10uM pan phosphoinositide 3-kinase (PI3K) inhibitor ZSTK434 for 6h. ATC code:---

Relative Expression (log2-ratio):-4.4043865
Number of Samples:4 / 9

Experimental	medulloblastoma study 2
	Primary tumor tissue sample from the infratentorial brain of pediatric patients with large-cell anaplastic medulloblastoma.
Control	non-tumor brain tissue
	Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

Relative Expression (log2-ratio):-4.1649523
Number of Samples:2 / 22

Experimental	lung cancer study 1 (PDX; non-small cell carcinoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary non-small cell carcinoma of the lung (subcutaneously implanted).
Control	lung cancer study 1 (PDX; adenocarcinoma, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenocarcinoma, NOS of the lung (subcutaneously implanted).

Relative Expression (log2-ratio):-4.1465917
Number of Samples:2 / 3

Experimental	glioma study 16 (BS-149)
	Human glioma cell line BS149 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control	normal astrocyte sample
	Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

Relative Expression (log2-ratio):-4.0247993
Number of Samples:17 / 9

Experimental	medulloblastoma study 1
	Primary tumor tissue sample from the infratentorial brain of pediatric patients with classical medulloblastoma.
Control	non-tumor brain tissue
	Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

Relative Expression (log2-ratio):3.9623804
Number of Samples:10 / 10

Experimental	ZSTK474 inhibitor (10uM); GM-CSF (1ng/ml) study 1
	Primary neutrophils isolated from blood samples of healthy volunteers purified over discontinuous plasma-percoll gradients. Neutrophils were treated with pan phosphoinositide 3-kinase (PI3K) inhibitor ZSTK474 (10uM) and granulocyte macrophage-colony stimulating factor (rhGM-CSF; 1ng/ml) for 6h. ATC code:---
Control	mock treated neutrophils (6h)
	Primary neutrophils isolated from blood samples of healthy volunteers purified over discontinuous plasma-percoll gradients. Neutrophils were treated with DMSO for 6h.

Relative Expression (log2-ratio):-3.886138
Number of Samples:22 / 12

Experimental	brain tumor study 1 (medulloblastoma)
	Primary tumor tissue sample from the brain of patients with medulloblastoma.
Control	normal brain tissue
	Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

Relative Expression (log2-ratio):3.7641678
Number of Samples:43 / 2

Experimental	lung cancer study 1 (PDX; squamous cell carcinoma, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary squamous cell carcinoma, NOS of the lung (subcutaneously implanted).
Control	lung cancer study 1 (PDX; non-small cell carcinoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary non-small cell carcinoma of the lung (subcutaneously implanted).