Organism: Homo sapiens
Gene: 39255_at
Selected probe(set): 206259_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39255_at (206259_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-3.5530138
Number of Samples:7 / 3

Experimental	Langerhans cell histiocytosis study 1
	Langerhans cell histiocytes (LCH) were isolated from LCH lesions of patients undergoing surgery. All patients had single system disease, five patients had bone lesion, one had skin lesion and one had mucosal manifestation. Langerhans cells histiocytes were purified by FACS as CD1a+ / CD270 + population with > 95% purity.
Control	normal plasmocytoid dendritic cell sample
	Normal plasmocytoid dendritic cells were isolated from peripheral blood of healthy adult donors. Plasmocytoid dendritic cells were defined as HLA-DR+ / CD45RAhi / CD11c- / BDCA2+ population.

Relative Expression (log2-ratio):3.1178093
Number of Samples:9 / 12

Experimental	Hep-G2
	Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:
Control	HepaRG
	Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

Relative Expression (log2-ratio):-2.934204
Number of Samples:4 / 8

Experimental	dendritic cell study 6 (gardiquimod; RN486)
	Plasmacytoid dendritic cells (pDCs) collected from blood of healthy donors and treated with gardiquimod (TLR7 agonist) and RN486 (Bruton’s tyrosine kinase; BTK inhibitor) for 3 hours. pDCs were sorted as CD303+, CD123+, CD45+, CD69+, CD40+, CD86+.
Control	dendritic cell study 6 (untreated)
	Plasmacytoid dendritic cells (pDCs) collected from blood of healthy donors. pDCs were sorted as CD303+, CD123+, CD45+, CD69+, CD40+, CD86+.

Relative Expression (log2-ratio):-2.499896
Number of Samples:7 / 8

Experimental	dendritic cell study 6 (gardiquimod)
	Plasmacytoid dendritic cells (pDCs) collected from blood of healthy donors and treated with gardiquimod (TLR7 agonist) for 3 hours. pDCs were sorted as CD303+, CD123+, CD45+, CD69+, CD40+, CD86+.
Control	dendritic cell study 6 (untreated)
	Plasmacytoid dendritic cells (pDCs) collected from blood of healthy donors. pDCs were sorted as CD303+, CD123+, CD45+, CD69+, CD40+, CD86+.

Relative Expression (log2-ratio):-2.3296852
Number of Samples:3 / 10

Experimental	HCC study 23 (portal vein infiltration)
	Tumor liver tissue samples derived from patients with hepatocellular carcinoma (HCC) with portal vein infiltration. Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai.
Control	adjacent liver tissue
	Normal adjacent liver tissue samples derived from patients with hepatocellular carcinoma (HCC). Samples were derived by laser capture microdissection (LCM) from patients with HCC from the Chinese National Human Genome Center at Shanghai.

Relative Expression (log2-ratio):-2.2891064
Number of Samples:14 / 69

Experimental	clear cell renal cell carcinoma study 4 (stage 3)
	Primary tumor tissue from patients with stage 3 clear cell renal cell carcinoma (ccRCC).
Control	normal kidney tissue
	Normal kidney tissue samples obtained from healthy individuals.

Relative Expression (log2-ratio):2.2791376
Number of Samples:3 / 3

Experimental	AsPC-1
	Human xenograft derived metastatic cancer cell line derived from mouse xenografts initiated with metastatic cells from the ascites derived from a 62 years old female Caucasian patient with pancreatic adenocarcinoma. Synonyms:AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 Cellosaurus code:
Control	BxPC-3
	Human pancreatic adenocarcinoma cell line derived from a 61 years old female patient. Synonyms:BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3 Cellosaurus code:

Relative Expression (log2-ratio):-2.2721329
Number of Samples:23 / 69

Experimental	clear cell renal cell carcinoma study 4 (stage 1)
	Primary tumor tissue from patients with stage 1 clear cell renal cell carcinoma (ccRCC).
Control	normal kidney tissue
	Normal kidney tissue samples obtained from healthy individuals.

Relative Expression (log2-ratio):2.2682457
Number of Samples:3 / 3

Experimental	TGF-ß study 9
	PANC-1 cells were grown to 70% confluency. Thereafter the cells were cultured for one day in serum-free conditions and then incubated for 48 hours with fresh media containing 5nM TGF-ß. Before harvesting, cells were washed 3x with PBS and lysed by direct addition of TRIzol reagent for RNA extraction.
Control	untreated PANC-1 cell sample
	PANC-1 cells were grown to 70% confluency. Thereafter the cells were cultured for one day in serum-free conditions and then incubated for 48 hours with plain fresh media. Before harvesting, cells were washed 3x with PBS and lysed by direct addition of TRIzol reagent for RNA extraction.

Relative Expression (log2-ratio):-2.2036476
Number of Samples:3 / 6

Experimental	4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone study 1 (10000 uM; Hep-G2)
	Hep-G2 cells exposed to 10000 uM 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (dissolved in PBS) for 72 hours. Cells were exposed to the chemical when 80% confluence was reached. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:---
Control	vehicle (PBS) treated Hep-G2 cell sample
	Hep-G2 cells treated with vehicle (PBS) for 72 hours. Cells were exposed to the vehicle when 80% confluence was reached.