TOP TEN perturbations for 39267_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39267_at
Selected probe(set): 210041_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39267_at (210041_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
brefeldin A study 1 (0.5ug/ml; HCT 116) / untreated HCT 116 cell sample
Relative Expression (log2-ratio):3.101612Number of Samples:3 / 3
Experimental | brefeldin A study 1 (0.5ug/ml; HCT 116) |
Human colon carcinoma cell line HCT116 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated HCT 116 cell sample |
Human colon carcinoma cell line HCT116 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
brefeldin A study 1 (0.5ug/ml; p53HCT116) / untreated p53HCT116 cell sample
Relative Expression (log2-ratio):3.0631151Number of Samples:2 / 3
Experimental | brefeldin A study 1 (0.5ug/ml; p53HCT116) |
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated p53HCT116 cell sample |
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
F. tularensis study 1 (tularensis Schu S4) / uninfected peripheral blood monocyte sample
Relative Expression (log2-ratio):2.5125656Number of Samples:4 / 6
Experimental | F. tularensis study 1 (tularensis Schu S4) |
Peripheral blood monocytes infected with the Schu S4 isolate of Francisella tularensis (100 MOI) for 24 hours. | |
Control | uninfected peripheral blood monocyte sample |
Peripheral blood monocytes uninfected. |
RhoA overexpr. study 1 (G14V) / mammary epithelial cell sample
Relative Expression (log2-ratio):-2.4750986Number of Samples:3 / 3
Experimental | RhoA overexpr. study 1 (G14V) |
Human mammary epithelial cells (hMEC) immortalized by retroviral transfection with a constitutively active RhoA mutant (G14V). Cells were cultivated in DFCI-I medium with 100ug/ml of G418. | |
Control | mammary epithelial cell sample |
Human mammary epithelial cells (hMEC) obtained during reduction mammoplasty. Cultivated in DFCI-I medium. |
RhoA overexpr. study 1 (WT) / mammary epithelial cell sample
Relative Expression (log2-ratio):-2.4608088Number of Samples:3 / 3
Experimental | RhoA overexpr. study 1 (WT) |
Human mammary epithelial cells (hMEC) immortalized by retroviral transfection with wild-type RhoA. Cells were cultivated in DFCI-I medium with 100ug/ml of G418. | |
Control | mammary epithelial cell sample |
Human mammary epithelial cells (hMEC) obtained during reduction mammoplasty. Cultivated in DFCI-I medium. |
lung cancer study 1 (PDX; non-small cell carcinoma; primary) / lung cancer study 1 (PDX; basaloid carcinoma; primary)
Relative Expression (log2-ratio):2.4144487Number of Samples:2 / 3
Experimental | lung cancer study 1 (PDX; non-small cell carcinoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary non-small cell carcinoma of the lung (subcutaneously implanted). | |
Control | lung cancer study 1 (PDX; basaloid carcinoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary basaloid carcinoma of the lung (subcutaneously implanted). |
RhoA overexpr. study 1 (T73A) / mammary epithelial cell sample
Relative Expression (log2-ratio):-2.370018Number of Samples:3 / 3
Experimental | RhoA overexpr. study 1 (T73A) |
Human mammary epithelial cells (hMEC) immortalized by retroviral transfection with a RhoA mutant (T73A) that is incapable to interacts with many well-known Rho effectors. Cells were cultivated in DFCI-I medium with 100ug/ml of G418. | |
Control | mammary epithelial cell sample |
Human mammary epithelial cells (hMEC) obtained during reduction mammoplasty. Cultivated in DFCI-I medium. |
conditioned medium study 1 (HS5) / untreated monocyte (CD14+) sample
Relative Expression (log2-ratio):2.356802Number of Samples:2 / 2
Experimental | conditioned medium study 1 (HS5) |
CD14+ monocytes treated with HS5 conditioned medium (CM) for 48h. | |
Control | untreated monocyte (CD14+) sample |
Untreated CD14+ monocytes from two different donors. |
endometriosis study 6 (minimal/mild endo.; pro. MCP) / normal endometrium tissue (pro. MCP)
Relative Expression (log2-ratio):-2.278078Number of Samples:12 / 20
Experimental | endometriosis study 6 (minimal/mild endo.; pro. MCP) |
Endometrial tissue samples from women with minimal or mild endometriosis and pelvic pain and/or infertility collected in the proliferative menstrual cycle phase (MCP). Endometriosis was diagnosed based on the revised American Fertility Society classification system. The MCP was determined by endometrial histology, confirmed by estradiol and progesterone serum levels and corroborated by 2 independent bioinformatics methods: clustering in unsupervised whole-transcriptome principal component analysis and cycle phase assignment classifier analysis. Patients with hormonal treatment within previous 3 months and presence of malignancy or major systemic disease were excluded. | |
Control | normal endometrium tissue (pro. MCP) |
Normal endometrial tissue samples from women collected in the proliferative menstrual cycle phase (MCP). The MCP was determined by endometrial histology, confirmed by estradiol and progesterone serum levels and corroborated by 2 independent bioinformatics methods: clustering in unsupervised whole-transcriptome principal component analysis and cycle phase assignment classifier analysis. |
lung cancer study 1 (PDX; non-small cell carcinoma; primary) / lung cancer study 1 (PDX; adenosquamous carcinoma; primary)
Relative Expression (log2-ratio):2.2570515Number of Samples:2 / 4
Experimental | lung cancer study 1 (PDX; non-small cell carcinoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary non-small cell carcinoma of the lung (subcutaneously implanted). | |
Control | lung cancer study 1 (PDX; adenosquamous carcinoma; primary) |
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenosquamous carcinoma of the lung (subcutaneously implanted). |