TOP TEN perturbations for 39301_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39301_at
Selected probe(set): 210944_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39301_at (210944_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)
Relative Expression (log2-ratio):-6.6305904Number of Samples:2 / 2
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, leiomyosarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, clear cell sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)
Relative Expression (log2-ratio):-6.212943Number of Samples:3 / 2
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, clear cell sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. |
HCC study 9 (HBV; HCV) / normal liver tissue
Relative Expression (log2-ratio):-4.11248Number of Samples:2 / 10
| Experimental | HCC study 9 (HBV; HCV) |
| Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection. | |
| Control | normal liver tissue |
| Normal, non-tumor liver tissue. |
clonidine study 5 (1615 uM; hES-Heps) / vehicle (DMSO) treated hES-Heps cell sample
Relative Expression (log2-ratio):3.959217Number of Samples:3 / 8
| Experimental | clonidine study 5 (1615 uM; hES-Heps) |
| hES-Heps cells exposed to 1615 uM clonidine (dissolved in 0.5% v/v DMSO) for 72 hours. Chemical was added at day 22 of differentiation. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:, , , , | |
| Control | vehicle (DMSO) treated hES-Heps cell sample |
| hES-Heps cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Vehicle was added at day 22 of differentiation. |
basal cell carcinoma study 3 / normal epidermal keratinocytes
Relative Expression (log2-ratio):3.906354Number of Samples:4 / 2
| Experimental | basal cell carcinoma study 3 |
| Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC). | |
| Control | normal epidermal keratinocytes |
| Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2. |
retina pigment epithelium study 2 (fetal) / retina pigment epithelium study 1 (fetal)
Relative Expression (log2-ratio):-3.7485533Number of Samples:12 / 6
| Experimental | retina pigment epithelium study 2 (fetal) |
| Human cultured fetal retina pigment epithelium samples obtained at gestation age between week 16-18. | |
| Control | retina pigment epithelium study 1 (fetal) |
| Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18. |
nephroblastoma study 2 / normal kidney tissue (adult)
Relative Expression (log2-ratio):-3.618248Number of Samples:4 / 3
| Experimental | nephroblastoma study 2 |
| Tumor tissue samples from the kidney of patients with Wilms’ tumor. | |
| Control | normal kidney tissue (adult) |
| Normal adult kidney tissue samples. |
oxyphilic adenoma study 1 / normal kidney tissue (adult)
Relative Expression (log2-ratio):-3.5075874Number of Samples:4 / 3
| Experimental | oxyphilic adenoma study 1 |
| Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma). | |
| Control | normal kidney tissue (adult) |
| Normal adult kidney tissue samples. |
glioma study 16 (oligodendroglioma) / normal brain tissue
Relative Expression (log2-ratio):-3.3669004Number of Samples:7 / 2
| Experimental | glioma study 16 (oligodendroglioma) |
| Primary oligodendroglioma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade OGII-III). | |
| Control | normal brain tissue |
| Normal brain tissue sample from healthy donors. |
renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue (adult)
Relative Expression (log2-ratio):-3.3364086Number of Samples:4 / 3
| Experimental | renal cell carcinoma study 6 (chromophobe type) |
| Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC). | |
| Control | normal kidney tissue (adult) |
| Normal adult kidney tissue samples. |
Organism: Homo sapiens
Gene: 39301_at
Selected probe(set): 210944_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39301_at (210944_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)
Relative Expression (log2-ratio):-6.6305904Number of Samples:2 / 2
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, leiomyosarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, leiomyosarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, clear cell sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic)
Relative Expression (log2-ratio):-6.212943Number of Samples:3 / 2
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, clear cell sarcoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary connective and soft tissue, clear cell sarcoma, NOS of the soft tissue (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. |
HCC study 9 (HBV; HCV) / normal liver tissue
Relative Expression (log2-ratio):-4.11248Number of Samples:2 / 10
| Experimental | HCC study 9 (HBV; HCV) |
| Liver tissue biopsy sample from patients with Hepatitis B and C infection related hepatocellular carcinoma (HCC) after resection. | |
| Control | normal liver tissue |
| Normal, non-tumor liver tissue. |
clonidine study 5 (1615 uM; hES-Heps) / vehicle (DMSO) treated hES-Heps cell sample
Relative Expression (log2-ratio):3.959217Number of Samples:3 / 8
| Experimental | clonidine study 5 (1615 uM; hES-Heps) |
| hES-Heps cells exposed to 1615 uM clonidine (dissolved in 0.5% v/v DMSO) for 72 hours. Chemical was added at day 22 of differentiation. Cells were treated with the IC10 determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (number of replicates, n = 3). ATC code:, , , , | |
| Control | vehicle (DMSO) treated hES-Heps cell sample |
| hES-Heps cells treated with vehicle (DMSO 0.5% v/v) for 72 hours. Vehicle was added at day 22 of differentiation. |
basal cell carcinoma study 3 / normal epidermal keratinocytes
Relative Expression (log2-ratio):3.906354Number of Samples:4 / 2
| Experimental | basal cell carcinoma study 3 |
| Primary tumor tissue from the eyelid of patients with basal cell carcinoma (BCC). | |
| Control | normal epidermal keratinocytes |
| Normal human epidermal keratinocytes (NHEK) (Kurabo Ind., Ltd., Osaka, Japan) cultured in HuMedia-KB2 medium at 37°C in humidified air containing 5% CO2. |
retina pigment epithelium study 2 (fetal) / retina pigment epithelium study 1 (fetal)
Relative Expression (log2-ratio):-3.7485533Number of Samples:12 / 6
| Experimental | retina pigment epithelium study 2 (fetal) |
| Human cultured fetal retina pigment epithelium samples obtained at gestation age between week 16-18. | |
| Control | retina pigment epithelium study 1 (fetal) |
| Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18. |
nephroblastoma study 2 / normal kidney tissue (adult)
Relative Expression (log2-ratio):-3.618248Number of Samples:4 / 3
| Experimental | nephroblastoma study 2 |
| Tumor tissue samples from the kidney of patients with Wilms’ tumor. | |
| Control | normal kidney tissue (adult) |
| Normal adult kidney tissue samples. |
oxyphilic adenoma study 1 / normal kidney tissue (adult)
Relative Expression (log2-ratio):-3.5075874Number of Samples:4 / 3
| Experimental | oxyphilic adenoma study 1 |
| Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma). | |
| Control | normal kidney tissue (adult) |
| Normal adult kidney tissue samples. |
glioma study 16 (oligodendroglioma) / normal brain tissue
Relative Expression (log2-ratio):-3.3669004Number of Samples:7 / 2
| Experimental | glioma study 16 (oligodendroglioma) |
| Primary oligodendroglioma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade OGII-III). | |
| Control | normal brain tissue |
| Normal brain tissue sample from healthy donors. |
renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue (adult)
Relative Expression (log2-ratio):-3.3364086Number of Samples:4 / 3
| Experimental | renal cell carcinoma study 6 (chromophobe type) |
| Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC). | |
| Control | normal kidney tissue (adult) |
| Normal adult kidney tissue samples. |