TOP TEN perturbations for 39322_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39322_at
Selected probe(set): 210307_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39322_at (210307_s_at) across 6674 perturbations tested by GENEVESTIGATOR:
heat shock study 3 / untreated THP-1 cell sample
Relative Expression (log2-ratio):2.3756475Number of Samples:3 / 3
Experimental | heat shock study 3 |
Cultured THP-1 mononuclear cells were treated with heat shock (43°C) for 1 hour followed by a 4 hour recovery period at 37°C. | |
Control | untreated THP-1 cell sample |
Cultured THP-1 mononuclear cells were cultured in basal growth media at 37°C. |
sapphyrin PCI-5002; ZnOAc2 study 1 / mannitol treated A549 cell sample
Relative Expression (log2-ratio):1.3700933Number of Samples:3 / 3
Experimental | sapphyrin PCI-5002; ZnOAc2 study 1 |
A549 human lung cancer cells were seeded 8 days. At 4 hours prior to RNA isolation, PCI-5002 (10 μM final concentration) + ZnOAc2 (25 μM final concentration) solution was added to the cultures. ATC code:--- | |
Control | mannitol treated A549 cell sample |
A549 human lung cancer cells were seeded 8 days. At 4 hours prior to RNA isolation, 5% mannitol solution was added to the cultures. |
TGF-ß study 5 (intermediate) / untreated A549 cell sample
Relative Expression (log2-ratio):1.1232185Number of Samples:9 / 3
Experimental | TGF-ß study 5 (intermediate) |
Human A549 cells were treated with 5ng/ml porcine TGF-ß after serum-starving for 24h. Samples were taken 8, 16, 24 hours after TGF-ß treatment. | |
Control | untreated A549 cell sample |
A549 cells were grown for 24 hours. Samples were taken immediately before TGF-ß treatment. |
atopic dermatitis study 21 (non-lesional; whole skin) / normal skin tissue
Relative Expression (log2-ratio):-1.1185131Number of Samples:5 / 6
Experimental | atopic dermatitis study 21 (non-lesional; whole skin) |
Non-lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %. | |
Control | normal skin tissue |
Full thickness skin samples isolated from healthy subjects by laser capture microdissection. |
IgA nephropathy study 8 / control glomerulus tissue
Relative Expression (log2-ratio):-1.0669899Number of Samples:20 / 20
Experimental | IgA nephropathy study 8 |
Hand-microdissected glomerular tissue samples derived from kidney biopsies of patients with IgA nephropathy (IgAN). Whole-core patient biopsies were obtained as part of routine renal biopsy procedures. | |
Control | control glomerulus tissue |
Hand-microdissected glomerular tissue samples derived from kidney biopsies of healthy living kidney transplant donors. The biopsies were taken after reperfusion in the kidney transplant recipient. |
brefeldin A study 1 (0.5ug/ml; p53HCT116) / untreated p53HCT116 cell sample
Relative Expression (log2-ratio):-1.0514841Number of Samples:2 / 3
Experimental | brefeldin A study 1 (0.5ug/ml; p53HCT116) |
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was treated with 0.5 ug/ml brefeldin-A for 24 hours in McCOYs 5A medium supplemented with 10% heat inactivated FBS. ATC code:--- | |
Control | untreated p53HCT116 cell sample |
Derived human colon carcinoma cell line p53HCT116 with knockout gene for p53 was grown in McCOYs 5A medium supplemented with 10% heat inactivated FBS. |
epigallocatechin gallate study 1 (45840ng/ml) / vehicle (DME) treated bronchial epithelial cell sample
Relative Expression (log2-ratio):-0.9905977Number of Samples:3 / 17
Experimental | epigallocatechin gallate study 1 (45840ng/ml) |
Bronchial epithelial cells (NHBE) treated with epigallocatechin gallate (45840ng/ml; vendor: Santa Cruz / catalog number: sc-200802 / catalog name: (-)-Epigallocatechin Gallate) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:--- | |
Control | vehicle (DME) treated bronchial epithelial cell sample |
Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). |
expO ovary cancer study 1 (transitional cell carcinoma, NOS; primary) / expO ovary cancer study 1 (adenocarcinoma, NOS; primary)
Relative Expression (log2-ratio):0.9606314Number of Samples:2 / 4
Experimental | expO ovary cancer study 1 (transitional cell carcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the ovary of patients with transitional cell carcinoma (NOS). | |
Control | expO ovary cancer study 1 (adenocarcinoma, NOS; primary) |
Primary tumor tissue samples obtained from the ovary of patients with adenocarcinoma (NOS). |
ovarian tumor study 17 / normal ovarian surface epithelial cell sample
Relative Expression (log2-ratio):0.9488354Number of Samples:9 / 10
Experimental | ovarian tumor study 17 |
Human epithelial tumor cell samples from the ovary of patients with primary clear cell carcinoma. Samples were derived by laser capture microdissection (LCM). | |
Control | normal ovarian surface epithelial cell sample |
Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from donors with non-cancerous, benign gynecological diseases. |
adrenal gland cancer study 4 / normal adrenal cortex tissue
Relative Expression (log2-ratio):-0.9107027Number of Samples:43 / 4
Experimental | adrenal gland cancer study 4 |
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC). | |
Control | normal adrenal cortex tissue |
Histological normal adrenal gland cortical tissue samples derived after autopsy. |