TOP TEN perturbations for 39345_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39345_at
Selected probe(set): 200701_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39345_at (200701_at) across 6674 perturbations tested by GENEVESTIGATOR:
expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Relative Expression (log2-ratio):3.713211Number of Samples:2 / 6
| Experimental | expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) |
| Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS). | |
| Control | expO lung cancer study 1 (neuroendocrine carcinoma; primary) |
| Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma. |
expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (adenosquamous carcinoma; primary)
Relative Expression (log2-ratio):-3.3305225Number of Samples:6 / 3
| Experimental | expO lung cancer study 1 (neuroendocrine carcinoma; primary) |
| Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma. | |
| Control | expO lung cancer study 1 (adenosquamous carcinoma; primary) |
| Primary tumor tissue samples obtained from the lung of patients with adenosquamous carcinoma. |
small cell lung cancer study 4 (XCL from PDX) / small cell lung cancer study 4 (XCL from CDX)
Relative Expression (log2-ratio):-3.2116365Number of Samples:3 / 11
| Experimental | small cell lung cancer study 4 (XCL from PDX) |
| Xenograft-derived cell lines (XCL) established from a small cell lung carcinoma (SCLC) patient derived xenografts (PDX). The discarded tissue from three chemo-naive patients (LX22; LX33 and LX35) was obtained during bronchoscopy and used to generate a xenograft. Aseptically resuspended tumour cells were injected s.c. in the flanks of nonobese diabetic/severe combined immunodeficient mice. The mice were sacrificed when the P0 tumors reached 1cm in diameter. Obtained cells were used for conventional cell culture cultivation. | |
| Control | small cell lung cancer study 4 (XCL from CDX) |
| Xenograft-derived cell lines (XCL) established from a small cell lung carcinoma (SCLC) publicly available cell lines derived xenografts (CDX derived cell lines). Xenografts were grown in the flanks of a nude mice. Obtained cells were cultivated under conventional tissue culture conditions. |
expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (bronchiolo-alveolar adenocarcinoma; primary)
Relative Expression (log2-ratio):-3.1542377Number of Samples:6 / 13
| Experimental | expO lung cancer study 1 (neuroendocrine carcinoma; primary) |
| Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma. | |
| Control | expO lung cancer study 1 (bronchiolo-alveolar adenocarcinoma; primary) |
| Primary tumor tissue samples obtained from the lung of patients with bronchiolo-alveolar adenocarcinoma. |
expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (mucinous adenocarcinoma; primary)
Relative Expression (log2-ratio):-2.947442Number of Samples:6 / 4
| Experimental | expO lung cancer study 1 (neuroendocrine carcinoma; primary) |
| Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma. | |
| Control | expO lung cancer study 1 (mucinous adenocarcinoma; primary) |
| Primary tumor tissue samples obtained from the lung of patients with mucinous adenocarcinoma. |
expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (adenocarcinoma, NOS; primary)
Relative Expression (log2-ratio):-2.7782154Number of Samples:6 / 36
| Experimental | expO lung cancer study 1 (neuroendocrine carcinoma; primary) |
| Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma. | |
| Control | expO lung cancer study 1 (adenocarcinoma, NOS; primary) |
| Primary tumor tissue samples obtained from the lung of patients with adenocarcinoma (NOS). |
esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; metastatic) / esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; primary)
Relative Expression (log2-ratio):-2.7110891Number of Samples:2 / 3
| Experimental | esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; metastatic) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary squamous cell carcinoma, NOS of the oesophagus (subcutaneously implanted). Metastatic site of patient tumor sample is not reported. | |
| Control | esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary squamous cell carcinoma, NOS of the oesophagus (subcutaneously implanted). |
expO breast cancer study 1 (papillary carcinoma, NOS; primary) / expO breast cancer study 1 (intraductal carcinoma; in situ)
Relative Expression (log2-ratio):-2.626934Number of Samples:2 / 3
| Experimental | expO breast cancer study 1 (papillary carcinoma, NOS; primary) |
| Primary tumor tissue samples obtained from the breast of patients with papillary carcinoma (NOS). | |
| Control | expO breast cancer study 1 (intraductal carcinoma; in situ) |
| Tumor tissue samples obtained from the breast of patients with intraductal carcinoma. |
small cell lung cancer study 4 (2. gen. PDX) / small cell lung cancer study 4 (2. gen. CDX)
Relative Expression (log2-ratio):-2.5356236Number of Samples:4 / 12
| Experimental | small cell lung cancer study 4 (2. gen. PDX) |
| Xenografts (secondary) tumor tissue samples derived from a PDX-derived cell lines. A patient derived xenograft (PDX)-derived cell lines were grown under conventional tissue culture conditions for six months and then reimplanted to generate secondary xenografts (2. gen.). | |
| Control | small cell lung cancer study 4 (2. gen. CDX) |
| Xenografts (secondary) tumor tissue samples derived from a CDX-derived cell lines. A cell line derived xenograft (CDX)-derived cell lines were grown under conventional tissue culture conditions for six months and then reimplanted to generate secondary xenografts (2. gen.). |
dysferlinopathy study 2 (LGMD2B; severe) / normal vastus lateralis tissue
Relative Expression (log2-ratio):2.3787298Number of Samples:2 / 6
| Experimental | dysferlinopathy study 2 (LGMD2B; severe) |
| Biopsies of vastus lateralis muscle from male patients with limb-girdle muscular dystrophy 2B (LGMD2B) and severe fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and dysferlin mutation. | |
| Control | normal vastus lateralis tissue |
| Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments. |