TOP TEN perturbations for 39345_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39345_at
Selected probe(set): 200701_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39345_at (200701_at) across 6674 perturbations tested by GENEVESTIGATOR:

expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO lung cancer study 1 (neuroendocrine carcinoma; primary)

Relative Expression (log2-ratio):3.713211
Number of Samples:2 / 6
Experimental expO lung cancer study 1 (papillary adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the lung of patients with papillary adenocarcinoma (NOS).
Control expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.

expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (adenosquamous carcinoma; primary)

Relative Expression (log2-ratio):-3.3305225
Number of Samples:6 / 3
Experimental expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.
Control expO lung cancer study 1 (adenosquamous carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with adenosquamous carcinoma.

small cell lung cancer study 4 (XCL from PDX) / small cell lung cancer study 4 (XCL from CDX)

Relative Expression (log2-ratio):-3.2116365
Number of Samples:3 / 11
Experimental small cell lung cancer study 4 (XCL from PDX)
Xenograft-derived cell lines (XCL) established from a small cell lung carcinoma (SCLC) patient derived xenografts (PDX). The discarded tissue from three chemo-naive patients (LX22; LX33 and LX35) was obtained during bronchoscopy and used to generate a xenograft. Aseptically resuspended tumour cells were injected s.c. in the flanks of nonobese diabetic/severe combined immunodeficient mice. The mice were sacrificed when the P0 tumors reached 1cm in diameter. Obtained cells were used for conventional cell culture cultivation.
Control small cell lung cancer study 4 (XCL from CDX)
Xenograft-derived cell lines (XCL) established from a small cell lung carcinoma (SCLC) publicly available cell lines derived xenografts (CDX derived cell lines). Xenografts were grown in the flanks of a nude mice. Obtained cells were cultivated under conventional tissue culture conditions.

expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (bronchiolo-alveolar adenocarcinoma; primary)

Relative Expression (log2-ratio):-3.1542377
Number of Samples:6 / 13
Experimental expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.
Control expO lung cancer study 1 (bronchiolo-alveolar adenocarcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with bronchiolo-alveolar adenocarcinoma.

expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (mucinous adenocarcinoma; primary)

Relative Expression (log2-ratio):-2.947442
Number of Samples:6 / 4
Experimental expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.
Control expO lung cancer study 1 (mucinous adenocarcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with mucinous adenocarcinoma.

expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):-2.7782154
Number of Samples:6 / 36
Experimental expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.
Control expO lung cancer study 1 (adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the lung of patients with adenocarcinoma (NOS).

esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; metastatic) / esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; primary)

Relative Expression (log2-ratio):-2.7110891
Number of Samples:2 / 3
Experimental esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; metastatic)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from a metastasis of patients with primary squamous cell carcinoma, NOS of the oesophagus (subcutaneously implanted). Metastatic site of patient tumor sample is not reported.
Control esophagus cancer study 1 (PDX; squamous cell carcinoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary squamous cell carcinoma, NOS of the oesophagus (subcutaneously implanted).

expO breast cancer study 1 (papillary carcinoma, NOS; primary) / expO breast cancer study 1 (intraductal carcinoma; in situ)

Relative Expression (log2-ratio):-2.626934
Number of Samples:2 / 3
Experimental expO breast cancer study 1 (papillary carcinoma, NOS; primary)
Primary tumor tissue samples obtained from the breast of patients with papillary carcinoma (NOS).
Control expO breast cancer study 1 (intraductal carcinoma; in situ)
Tumor tissue samples obtained from the breast of patients with intraductal carcinoma.

small cell lung cancer study 4 (2. gen. PDX) / small cell lung cancer study 4 (2. gen. CDX)

Relative Expression (log2-ratio):-2.5356236
Number of Samples:4 / 12
Experimental small cell lung cancer study 4 (2. gen. PDX)
Xenografts (secondary) tumor tissue samples derived from a PDX-derived cell lines. A patient derived xenograft (PDX)-derived cell lines were grown under conventional tissue culture conditions for six months and then reimplanted to generate secondary xenografts (2. gen.).
Control small cell lung cancer study 4 (2. gen. CDX)
Xenografts (secondary) tumor tissue samples derived from a CDX-derived cell lines. A cell line derived xenograft (CDX)-derived cell lines were grown under conventional tissue culture conditions for six months and then reimplanted to generate secondary xenografts (2. gen.).

dysferlinopathy study 2 (LGMD2B; severe) / normal vastus lateralis tissue

Relative Expression (log2-ratio):2.3787298
Number of Samples:2 / 6
Experimental dysferlinopathy study 2 (LGMD2B; severe)
Biopsies of vastus lateralis muscle from male patients with limb-girdle muscular dystrophy 2B (LGMD2B) and severe fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and dysferlin mutation.
Control normal vastus lateralis tissue
Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments.