TOP TEN perturbations for 39360_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39360_at
Selected probe(set): 210648_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39360_at (210648_x_at) across 6674 perturbations tested by GENEVESTIGATOR:
kidney transplantation study 15 (8 week) / normal monocyte (CD14+) sample
Relative Expression (log2-ratio):-2.4372578Number of Samples:2 / 5
| Experimental | kidney transplantation study 15 (8 week) |
| CD14+ monocyte samples derived from kidney transplant patients 8 weeks post-transplantation. Samples were collected 8 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH). | |
| Control | normal monocyte (CD14+) sample |
| CD14+ monocyte samples derived from healthy control subjects. |
oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample
Relative Expression (log2-ratio):-2.2670135Number of Samples:3 / 3
| Experimental | oncolytic herpes simplex virus study 2 |
| Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours. | |
| Control | mock infected peripheral nerve sheath tumor (S462) cell sample |
| Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours. |
granulomatosis with polyangiitis study 3 (orbital adipose tissue) / normal orbital adipose tissue
Relative Expression (log2-ratio):-2.1880293Number of Samples:9 / 22
| Experimental | granulomatosis with polyangiitis study 3 (orbital adipose tissue) |
| Orbital adipose tissue samples obtained from patients who suffered from granulomatosis with polyangiitis (GPA). Biopsies were formalin-fixed and paraffin-embedded. | |
| Control | normal orbital adipose tissue |
| Normal orbital adipose tissue samples. Samples were obtained from subjects with no history of orbital disease at the time of surgery such as fat typically excised and discarded as part of routine blepharoplasty or retrobulbar fat that is snared with the eye during enucleation. Biopsies were formalin-fixed and paraffin-embedded. |
sarcoidosis study 6 (orbital adipose tissue) / normal orbital adipose tissue
Relative Expression (log2-ratio):-1.8736773Number of Samples:7 / 22
| Experimental | sarcoidosis study 6 (orbital adipose tissue) |
| Orbital adipose tissue samples obtained from patients who suffered from sarcoidosis. Biopsies were formalin-fixed and paraffin-embedded. | |
| Control | normal orbital adipose tissue |
| Normal orbital adipose tissue samples. Samples were obtained from subjects with no history of orbital disease at the time of surgery such as fat typically excised and discarded as part of routine blepharoplasty or retrobulbar fat that is snared with the eye during enucleation. Biopsies were formalin-fixed and paraffin-embedded. |
septic shock study 3 (D1; survivor) / normal blood sample
Relative Expression (log2-ratio):1.8182487Number of Samples:34 / 22
| Experimental | septic shock study 3 (D1; survivor) |
| Blood samples from patients (survivors) collected at day 1 (D1) after the septic shock onset. According to day 28 survival status, patients were classified as survivors. Septic shock patients were identified according to the diagnostic criteria of the American College of Chest Physicians/Society of Critical Care Medicine (1992). The onset of septic shock was defined as the beginning of vasopressor therapy in combination with an identifiable site of infection, persisting hypotension - despite fluid resuscitation - and evidence of a systemic inflammatory response manifested by at least two of the following criteria: a) temperature >38ºC or <36ºC; b) heart rate >90 beats/min; c) respiratory rate >20 breaths/min; d) white blood cell count >12,000/mm3 or <4000/mm3. Excluded were subjects that were less than 18 years old and had aplasia or immunosuppressive disease (e.g. HIV infection). | |
| Control | normal blood sample |
| Blood samples from healthy subjects. |
ovarian tumor study 25 (serous ovarian cancer epithelium) / normal ovarian surface epithelium cell sample
Relative Expression (log2-ratio):-1.7484074Number of Samples:12 / 12
| Experimental | ovarian tumor study 25 (serous ovarian cancer epithelium) |
| Laser capture micro-dissected serous ovarian cancer epithelium cells derived from female individuals with primary papillary serous adenocarcinoma of the ovary. | |
| Control | normal ovarian surface epithelium cell sample |
| Normal ovarian surface epithelium cell (OSE) samples isolated from female individuals by laser capture micro-dissection (LCM). Indication for removal of healthy ovaries were others than ovary cancer. |
ovarian tumor study 13 / normal ovarian surface epithelial cell sample
Relative Expression (log2-ratio):-1.7425089Number of Samples:18 / 12
| Experimental | ovarian tumor study 13 |
| Human epithelial tumor cell samples from the ovary of patients with serous adenocarcinoma. Samples were derived by laser capture microdissection (LCM). | |
| Control | normal ovarian surface epithelial cell sample |
| Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from healthy donors. Samples were derived by cell surface brushing. |
septic shock study 3 (D1; non-survivor) / normal blood sample
Relative Expression (log2-ratio):1.7221451Number of Samples:17 / 22
| Experimental | septic shock study 3 (D1; non-survivor) |
| Blood samples from patients (non-survivors) collected at day 1 (D1) after the septic shock onset. According to day 28 survival status, patients were classified as non-survivors. Septic shock patients were identified according to the diagnostic criteria of the American College of Chest Physicians/Society of Critical Care Medicine (1992). The onset of septic shock was defined as the beginning of vasopressor therapy in combination with an identifiable site of infection, persisting hypotension - despite fluid resuscitation - and evidence of a systemic inflammatory response manifested by at least two of the following criteria: a) temperature >38ºC or <36ºC; b) heart rate >90 beats/min; c) respiratory rate >20 breaths/min; d) white blood cell count >12,000/mm3 or <4000/mm3. Excluded were subjects that were less than 18 years old and had aplasia or immunosuppressive disease (e.g. HIV infection). | |
| Control | normal blood sample |
| Blood samples from healthy subjects. |
nonspecific orbital inflammatory disease study 1 (lacrimal gland tissue) / normal lacrimal gland tissue
Relative Expression (log2-ratio):-1.7064877Number of Samples:42 / 7
| Experimental | nonspecific orbital inflammatory disease study 1 (lacrimal gland tissue) |
| Lacrimal gland tissue samples obtained from patients who suffered from nonspecific orbital inflammatory disease (NSOI). Biopsies were formalin-fixed and paraffin-embedded. | |
| Control | normal lacrimal gland tissue |
| Normal lacrimal gland tissue samples. The control tissue was obtained during surgery on eyes with non-inflamed orbits, such as blepharoplasties and enucleations. Biopsies were formalin-fixed and paraffin-embedded. |
colorectal adenoma study 2 / normal colon tissue
Relative Expression (log2-ratio):-1.6641092Number of Samples:5 / 6
| Experimental | colorectal adenoma study 2 |
| Laser microdissected human adenoma sample. | |
| Control | normal colon tissue |
| Laser microdissected human colonic epithelial cells sample. |