Organism: Homo sapiens
Gene: 39397_at
Selected probe(set): 209120_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39397_at (209120_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):6.3914194
Number of Samples:3 / 3

Experimental	hepatocyte-like cell differentiation study 1 (20d; HNF4 depl)
	Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09) and transfected with shRNA targeting HNF4A. ES cells were grown in human ES cell media DMEM/F12 and differentiated to mature hepatocytes for 20 days. Moreover hESc was stable transfected with lentivirus expressing an shRNA that efficiently depletes HNF4A.
Control	hepatocyte-like cell differentiation study 1 (5d)
	Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days.

Relative Expression (log2-ratio):5.5477533
Number of Samples:3 / 3

Experimental	hepatocyte-like cell differentiation study 1 (15d)
	Hepatocyte-like cells differentiated from human embryonic stem cells (ES, WA09), 15 days after the onset of differentiation. This stage is approximately corresponding to immature hepatocytes. Human H9 (WA09) ES cells were routinely cultured under low oxygen conditions (4% O2/5% CO2) in human ES cell media (DMEM/F12 medium supplemented with 20% knockout serum replacement, non essential amino acids, glutamine, penicillin/streptomycin and bFGF (4ng/ml) on Matrigel coated plates using MEF-conditioned human ES cell media. Differentiation was initiated by culture for 5 days with 100ng/ml Activin A in RPMI/B27 medium under ambient oxygen/5%CO2 followed by 5 days with 20ng/ml BMP4 /10ng/ml FGF-2 in RPMI/B27 under 4%O2/5%CO2, then 5 days with 20ng/ml HGF in RPMI/B27 supplement under 4%O2/5%CO2.
Control	hepatocyte-like cell differentiation study 1 (5d)
	Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days.

Relative Expression (log2-ratio):5.383909
Number of Samples:2 / 18

Experimental	Roberts syndrome study 1
	Lymphoblastoid cell line samples from probands with Roberts syndrome (RBS).
Control	normal lymphoblastoid cell line sample
	Lymphoblastoid cell line samples from healthy subjects.

Relative Expression (log2-ratio):4.8645277
Number of Samples:4 / 4

Experimental	stem cell differentiation study 59 (8d)
	WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper.
Control	normal embryonic stem cell sample (WA09)
	Undifferentiated WA09 embryonic stem cell samples.

Relative Expression (log2-ratio):-4.782853
Number of Samples:2 / 4

Experimental	R547 study 1 (24h)
	Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 24 hours at a 3xIC90 concentration of 5.1 μmol/L. ATC code:---
Control	vehicle (DMSO) treated DU145 cell sample
	Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 24 hours.

Relative Expression (log2-ratio):-4.624017
Number of Samples:3 / 4

Experimental	lung cancer study 1 (PDX; basaloid carcinoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary basaloid carcinoma of the lung (subcutaneously implanted).
Control	lung cancer study 1 (PDX; adenosquamous carcinoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary adenosquamous carcinoma of the lung (subcutaneously implanted).

Relative Expression (log2-ratio):-4.5186377
Number of Samples:3 / 3

Experimental	echinomycin study 1
	Echinomycin (100nM; 2h) treated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:---
Control	deferoxamine study 5
	Untreated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:

Relative Expression (log2-ratio):4.363758
Number of Samples:4 / 3

Experimental	lung cancer study 1 (PDX; pseudosarcomatous carcinoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary pseudosarcomatous carcinoma of the lung (subcutaneously implanted).
Control	lung cancer study 1 (PDX; basaloid carcinoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary basaloid carcinoma of the lung (subcutaneously implanted).

Relative Expression (log2-ratio):4.308058
Number of Samples:10 / 10

Experimental	breast cancer study 24
	Freshly purified CD4+ tumor-infiltrating T cells derived from female primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information. The initial tissue dissociation was performed mechanically, without enzymatic digestion.
Control	breast cancer study 22
	Freshly purified CD4+ T cells from peripheral blood of female donors with primary invasive breast ductal carcinoma. For individual patient characteristics see detailed sample information.

Relative Expression (log2-ratio):4.064827
Number of Samples:2 / 2

Experimental	CNS cancer study 1 (PDX; glioma, malignant, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary glioma, malignant, NOS of the central nervous system (subcutaneously implanted).
Control	CNS cancer study 1 (PDX; ependymoma, NOS; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary ependymoma, NOS of the central nervous system (subcutaneously implanted).