TOP TEN perturbations for 39411_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39411_at
Selected probe(set): 212665_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39411_at (212665_at) across 6674 perturbations tested by GENEVESTIGATOR:

echinomycin study 1 / deferoxamine study 5

Relative Expression (log2-ratio):-4.805355
Number of Samples:3 / 3
Experimental echinomycin study 1
Echinomycin (100nM; 2h) treated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:---
Control deferoxamine study 5
Untreated human astroglioma (U251) cells, stimulated with deferoxamine (DFO; 300mM; 16h). ATC code:

actinomycin D study 1 / mannitol treated A549 cell sample

Relative Expression (log2-ratio):-4.1306715
Number of Samples:3 / 3
Experimental actinomycin D study 1
A549 human lung cancer cells were seeded eights days prior to treatment of non-cycling plateau phase cultures with drug. At four hours prior to RNA isolation, actinomycin D (5 ug/mL final concentration) was added to the culture. ATC code:
Control mannitol treated A549 cell sample
A549 human lung cancer cells were seeded eights days prior to treatment of non-cycling plateau phase cultures with drug. At four hours prior to RNA isolation, mannitol (5% final concentration) was added to the culture.

breast cancer study 3 / normal organelle sample

Relative Expression (log2-ratio):-3.6048622
Number of Samples:17 / 12
Experimental breast cancer study 3
Breast basal tumor samples.
Control normal organelle sample
Normal organelle samples.

smoking study 14 (0.003puffs/ml) / untreated A549 cell sample

Relative Expression (log2-ratio):3.4403477
Number of Samples:3 / 3
Experimental smoking study 14 (0.003puffs/ml)
A549 lung cancer cells cultured in normal media and treated with 0.003 puffs/ml tobacco smoke condensate (TSC). TSC were derived from Kentucky Reference 1R4F research blend cigarettes at a concentration of 9 puffs, 10 mg tar/mL in DMSO.
Control untreated A549 cell sample
A549 lung cancer cells cultured in normal media, untreated.

R547 study 1 (6h) / vehicle (DMSO) treated DU145 cell sample

Relative Expression (log2-ratio):-3.3132553
Number of Samples:4 / 4
Experimental R547 study 1 (6h)
Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 6 hours at a 3xIC90 concentration of 5.1 μmol/L. ATC code:---
Control vehicle (DMSO) treated DU145 cell sample
Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 6 hours.

B-CLL study 11 (rolipram) / rolipram study 4 (normal B-cell; 20uM)

Relative Expression (log2-ratio):-3.267393
Number of Samples:4 / 4
Experimental B-CLL study 11 (rolipram)
Peripheral blood mononuclear cells (PBMCs) obtained from chronic lymphocytic leukemia (CLL) patients and in vitro treated with rolipram (20 uM, cyclic nucleotide phosphodiesterase (PDE4) inhibitor) for 4 hours. PBMCs’ samples contained 90% CD19+ CD5+ B lineage CLL cells (B-CLL). Inclusion criteria: untreated CLL patients or at least 1 month after chemotherapy. Exclusion criteria: patients with active infections or other serious medical conditions or with white blood cell (WBC) counts of 15,000/l. ATC code:---
Control rolipram study 4 (normal B-cell; 20uM)
MACS purified resting B-cells from healthy donor peripheral blood treated with rolipram (20 uM, cyclic nucleotide phosphodiesterase (PDE4) inhibitor) for 4 hours. ATC code:---

adrenal gland cancer study 5 (ACC) / normal adrenal cortex tissue

Relative Expression (log2-ratio):-3.189291
Number of Samples:34 / 4
Experimental adrenal gland cancer study 5 (ACC)
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma (ACC).
Control normal adrenal cortex tissue
Histological normal adrenal gland cortical tissue samples.

IgA nephropathy study 8 / control glomerulus tissue

Relative Expression (log2-ratio):-3.1532898
Number of Samples:20 / 20
Experimental IgA nephropathy study 8
Hand-microdissected glomerular tissue samples derived from kidney biopsies of patients with IgA nephropathy (IgAN). Whole-core patient biopsies were obtained as part of routine renal biopsy procedures.
Control control glomerulus tissue
Hand-microdissected glomerular tissue samples derived from kidney biopsies of healthy living kidney transplant donors. The biopsies were taken after reperfusion in the kidney transplant recipient.

smoking study 14 (0.001puffs/ml) / untreated A549 cell sample

Relative Expression (log2-ratio):3.1237698
Number of Samples:3 / 3
Experimental smoking study 14 (0.001puffs/ml)
A549 lung cancer cells cultured in normal media and treated with 0.001 puffs/ml tobacco smoke condensate (TSC). TSC were derived from Kentucky Reference 1R4F research blend cigarettes at a concentration of 9 puffs, 10 mg tar/mL in DMSO.
Control untreated A549 cell sample
A549 lung cancer cells cultured in normal media, untreated.

adrenal gland cancer study 2 / normal adrenal cortex tissue

Relative Expression (log2-ratio):-3.05054
Number of Samples:31 / 10
Experimental adrenal gland cancer study 2
Primary tumor tissue samples of the adrenal cortex from patients with adrenocortical carcinoma.
Control normal adrenal cortex tissue
Unaffected adrenal cortex tissue from control objects.