TOP TEN perturbations for 39416_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39416_at
Selected probe(set): 209154_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39416_at (209154_at) across 6674 perturbations tested by GENEVESTIGATOR:

F. tularensis study 1 (tularensis Schu S4) / uninfected peripheral blood monocyte sample

Relative Expression (log2-ratio):-3.7263107
Number of Samples:4 / 6
Experimental F. tularensis study 1 (tularensis Schu S4)
Peripheral blood monocytes infected with the Schu S4 isolate of Francisella tularensis (100 MOI) for 24 hours.
Control uninfected peripheral blood monocyte sample
Peripheral blood monocytes uninfected.

F. tularensis study 1 (novicida) / uninfected peripheral blood monocyte sample

Relative Expression (log2-ratio):-2.7580023
Number of Samples:4 / 6
Experimental F. tularensis study 1 (novicida)
Peripheral blood monocytes infected with the Francisella tularensis subspecies novicida isolate U112 (100 MOI) for 24 hours.
Control uninfected peripheral blood monocyte sample
Peripheral blood monocytes uninfected.

hepatocyte (ESC) / Hep-G2

Relative Expression (log2-ratio):2.6339102
Number of Samples:8 / 9
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (adenosquamous carcinoma; primary)

Relative Expression (log2-ratio):-2.5706806
Number of Samples:6 / 3
Experimental expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.
Control expO lung cancer study 1 (adenosquamous carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with adenosquamous carcinoma.

oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample

Relative Expression (log2-ratio):-2.5031004
Number of Samples:3 / 3
Experimental oncolytic herpes simplex virus study 2
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control mock infected peripheral nerve sheath tumor (S462) cell sample
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours.

colorectal adenoma study 2 / normal colon tissue

Relative Expression (log2-ratio):-2.4834213
Number of Samples:5 / 6
Experimental colorectal adenoma study 2
Laser microdissected human adenoma sample.
Control normal colon tissue
Laser microdissected human colonic epithelial cells sample.

valproic acid study 25 (5000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-2.4056225
Number of Samples:2 / 2
Experimental valproic acid study 25 (5000uM)
Hepatocytes treated with compound: valproic acid (5000uM; CHEMBL109) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (mucinous adenocarcinoma; primary)

Relative Expression (log2-ratio):-2.362979
Number of Samples:6 / 4
Experimental expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.
Control expO lung cancer study 1 (mucinous adenocarcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with mucinous adenocarcinoma.

expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO kidney cancer study 1 (granular cell carcinoma; primary)

Relative Expression (log2-ratio):2.33319
Number of Samples:22 / 4
Experimental expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the kidney of patients with papillary adenocarcinoma (NOS).
Control expO kidney cancer study 1 (granular cell carcinoma; primary)
Primary tumor tissue samples obtained from the kidney of patients with granular cell carcinoma.

Alzheimer's disease study 8 / normal pyramidal neuron (middle temporal gyrus)

Relative Expression (log2-ratio):2.2734785
Number of Samples:15 / 12
Experimental Alzheimer's disease study 8
Cortical layer III pyramidal neurons of the middle temporal gyrus of clinically and neuropathologically classified late-onset Alzheimer┬┤s disease afflicted individuals. Subjects in this group had a Braak stage of V or VI with a CERAD score of moderate or frequent.
Control normal pyramidal neuron (middle temporal gyrus)
Cortical layer III pyramidal neurons of the middle temporal gyrus of clinically classified as neurologically normal individuals. Subjects in this group had a Braak stage ranging from I to II with a infrequent Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuritic plaque density.

Organism: Homo sapiens
Gene: 39416_at
Selected probe(set): 209154_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39416_at (209154_at) across 6674 perturbations tested by GENEVESTIGATOR:

F. tularensis study 1 (tularensis Schu S4) / uninfected peripheral blood monocyte sample

Relative Expression (log2-ratio):-3.7263107
Number of Samples:4 / 6
Experimental F. tularensis study 1 (tularensis Schu S4)
Peripheral blood monocytes infected with the Schu S4 isolate of Francisella tularensis (100 MOI) for 24 hours.
Control uninfected peripheral blood monocyte sample
Peripheral blood monocytes uninfected.

F. tularensis study 1 (novicida) / uninfected peripheral blood monocyte sample

Relative Expression (log2-ratio):-2.7580023
Number of Samples:4 / 6
Experimental F. tularensis study 1 (novicida)
Peripheral blood monocytes infected with the Francisella tularensis subspecies novicida isolate U112 (100 MOI) for 24 hours.
Control uninfected peripheral blood monocyte sample
Peripheral blood monocytes uninfected.

hepatocyte (ESC) / Hep-G2

Relative Expression (log2-ratio):2.6339102
Number of Samples:8 / 9
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control Hep-G2
Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (adenosquamous carcinoma; primary)

Relative Expression (log2-ratio):-2.5706806
Number of Samples:6 / 3
Experimental expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.
Control expO lung cancer study 1 (adenosquamous carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with adenosquamous carcinoma.

oncolytic herpes simplex virus study 2 / mock infected peripheral nerve sheath tumor (S462) cell sample

Relative Expression (log2-ratio):-2.5031004
Number of Samples:3 / 3
Experimental oncolytic herpes simplex virus study 2
Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control mock infected peripheral nerve sheath tumor (S462) cell sample
Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours.

colorectal adenoma study 2 / normal colon tissue

Relative Expression (log2-ratio):-2.4834213
Number of Samples:5 / 6
Experimental colorectal adenoma study 2
Laser microdissected human adenoma sample.
Control normal colon tissue
Laser microdissected human colonic epithelial cells sample.

valproic acid study 25 (5000uM) / vehicle (medium) treated hepatocyte sample

Relative Expression (log2-ratio):-2.4056225
Number of Samples:2 / 2
Experimental valproic acid study 25 (5000uM)
Hepatocytes treated with compound: valproic acid (5000uM; CHEMBL109) for 24 hours. ATC code:
Control vehicle (medium) treated hepatocyte sample
Hepatocytes treated with vehicle (medium) for 24 hours.

expO lung cancer study 1 (neuroendocrine carcinoma; primary) / expO lung cancer study 1 (mucinous adenocarcinoma; primary)

Relative Expression (log2-ratio):-2.362979
Number of Samples:6 / 4
Experimental expO lung cancer study 1 (neuroendocrine carcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with neuroendocrine carcinoma.
Control expO lung cancer study 1 (mucinous adenocarcinoma; primary)
Primary tumor tissue samples obtained from the lung of patients with mucinous adenocarcinoma.

expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary) / expO kidney cancer study 1 (granular cell carcinoma; primary)

Relative Expression (log2-ratio):2.33319
Number of Samples:22 / 4
Experimental expO kidney cancer study 1 (papillary adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the kidney of patients with papillary adenocarcinoma (NOS).
Control expO kidney cancer study 1 (granular cell carcinoma; primary)
Primary tumor tissue samples obtained from the kidney of patients with granular cell carcinoma.

Alzheimer's disease study 8 / normal pyramidal neuron (middle temporal gyrus)

Relative Expression (log2-ratio):2.2734785
Number of Samples:15 / 12
Experimental Alzheimer's disease study 8
Cortical layer III pyramidal neurons of the middle temporal gyrus of clinically and neuropathologically classified late-onset Alzheimer┬┤s disease afflicted individuals. Subjects in this group had a Braak stage of V or VI with a CERAD score of moderate or frequent.
Control normal pyramidal neuron (middle temporal gyrus)
Cortical layer III pyramidal neurons of the middle temporal gyrus of clinically classified as neurologically normal individuals. Subjects in this group had a Braak stage ranging from I to II with a infrequent Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuritic plaque density.