Organism: Homo sapiens
Gene: 39524_at
Selected probe(set): 206455_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39524_at (206455_s_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-2.8743029
Number of Samples:19 / 17

Experimental	rhegmatogenous retinal detachment study 1
	Retina tissue samples from patients with retinal detachment obtained by vitrectomy.
Control	normal retina tissue
	Postmortem retina tissue samples from healthy patients without any diseases of the eye.

Relative Expression (log2-ratio):-1.1668034
Number of Samples:5 / 6

Experimental	atopic dermatitis study 21 (non-lesional; whole skin)
	Non-lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control	normal skin tissue
	Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

Relative Expression (log2-ratio):1.1640301
Number of Samples:2 / 6

Experimental	retina pigment epithelium study 1 (adult)
	Postmortem human native retina pigment epithelium samples from adult individuals.
Control	retina pigment epithelium study 1 (fetal)
	Human native fetal retina pigment epithelium samples obtained at gestation age between week 16-18.

Relative Expression (log2-ratio):-1.109828
Number of Samples:2 / 2

Experimental	conditioned medium study 1 (HS5)
	CD14+ monocytes treated with HS5 conditioned medium (CM) for 48h.
Control	untreated monocyte (CD14+) sample
	Untreated CD14+ monocytes from two different donors.

Relative Expression (log2-ratio):1.077776
Number of Samples:8 / 30

Experimental	pediatric septic shock study 3 (infant; subclass A)
	Whole blood samples obtained from infants (1 month – 1 year) with septic shock subclass A. The samples were obtained within 24 hours of admission to the pediatric intensive care unit. Two children did not survive. The subclass A was defined based on an empiric, discovery oriented expression filter and unsupervised hierarchical clustering. Patients in subclass A (when all age groups were pooled) had a significantly higher illness severity level (PRISM III score = 20.5, intra-quartile range (IQR) 12.5 – 32.5), a greater degree of organ failure – maximum number of organ failures 3 (IQR 3 - 4), and a higher mortality rate, a significantly higher incidence of documented Gram-positive bacterial infection and were significantly younger compared with other subclasses.
Control	pediatric septic shock study 3 (infant)
	Whole blood obtained from infants (1 month – 1 year) with septic shock. The samples were obtained within 24 hours of admission to the pediatric intensive care unit (day 1). Five children did not survive.

Relative Expression (log2-ratio):-1.0289507
Number of Samples:2 / 2

Experimental	conditioned medium study 1 (HS27a)
	CD14+ monocytes treated with HS27a conditioned medium (CM) for 48h.
Control	untreated monocyte (CD14+) sample
	Untreated CD14+ monocytes from two different donors.

Relative Expression (log2-ratio):0.95042896
Number of Samples:4 / 23

Experimental	pediatric septic shock study 3 (toddler; subclass A)
	Whole blood samples obtained from toddlers (2 – 5 years) with septic shock subclass A. The samples were obtained within 24 hours of admission to the pediatric intensive care unit. One child did not survive. The subclass A was defined based on an empiric, discovery oriented expression filter and unsupervised hierarchical clustering. Patients in subclass A (when all age groups were pooled) had a significantly higher illness severity level (PRISM III score = 20.5, intra-quartile range (IQR) 12.5 – 32.5), a greater degree of organ failure – maximum number of organ failures 3 (IQR 3 - 4), and a higher mortality rate, a significantly higher incidence of documented Gram-positive bacterial infection and were significantly younger compared with other subclasses.
Control	pediatric septic shock study 3 (toddler)
	Whole blood obtained from toddlers (2 – 5 years) with septic shock. The samples were obtained within 24 hours of admission to the pediatric intensive care unit (day 1). Two children did not survive.

Relative Expression (log2-ratio):-0.8414612
Number of Samples:5 / 6

Experimental	atopic dermatitis study 21 (lesional; whole skin)
	Lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control	normal skin tissue
	Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

Relative Expression (log2-ratio):-0.82407856
Number of Samples:11 / 6

Experimental	ovarian tumor study 11 (low grade)
	Human microdissected tumor cells from the ovary of patients with low grade serous carcinoma.
Control	normal ovarian surface epithelial cell sample
	Human microdissected ovarian surface epithelial cell sample from the ovary of healthy individuals.

Relative Expression (log2-ratio):-0.80762005
Number of Samples:2 / 6

Experimental	dysferlinopathy study 2 (LGMD2B; severe)
	Biopsies of vastus lateralis muscle from male patients with limb-girdle muscular dystrophy 2B (LGMD2B) and severe fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and dysferlin mutation.
Control	normal vastus lateralis tissue
	Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments.