TOP TEN perturbations for 39542_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39542_at
Selected probe(set): 201341_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39542_at (201341_at) across 6674 perturbations tested by GENEVESTIGATOR:
HIV-associated neurocognitive disorder study 7 (normal) / HIV-associated neurocognitive disorder study 6 (normal)
Relative Expression (log2-ratio):6.0934525Number of Samples:2 / 2
| Experimental | HIV-associated neurocognitive disorder study 7 (normal) |
| Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients received antiretroviral therapy (ART). | |
| Control | HIV-associated neurocognitive disorder study 6 (normal) |
| Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with normal brain pathology. The patients did not receive any antiretroviral therapy (ART). |
epigallocatechin gallate study 1 (45840ng/ml) / vehicle (DME) treated bronchial epithelial cell sample
Relative Expression (log2-ratio):-4.5046616Number of Samples:3 / 17
| Experimental | epigallocatechin gallate study 1 (45840ng/ml) |
| Bronchial epithelial cells (NHBE) treated with epigallocatechin gallate (45840ng/ml; vendor: Santa Cruz / catalog number: sc-200802 / catalog name: (-)-Epigallocatechin Gallate) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:--- | |
| Control | vehicle (DME) treated bronchial epithelial cell sample |
| Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, synovial sarcoma, spindle cell; primary) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, liposarcoma, NOS; primary)
Relative Expression (log2-ratio):3.9407167Number of Samples:6 / 2
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, synovial sarcoma, spindle cell; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, synovial sarcoma, spindle cell of the soft tissue (subcutaneously implanted). | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, liposarcoma, NOS; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, liposarcoma, NOS of the soft tissue (subcutaneously implanted). |
dengue fever study 10 (DF) / normal naive CD8 T cell sample
Relative Expression (log2-ratio):3.9289846Number of Samples:3 / 5
| Experimental | dengue fever study 10 (DF) |
| Activated CD8 T cells derived from peripheral blood mononuclear cells (PBMCs) of Thai individuals with Dengue fever (DF) characterized by the WHO 1997. FACS-sorted CD3+, CD8+, CD45RA+, and CCR7+ naive CD8 T subtype cells were used for analysis. | |
| Control | normal naive CD8 T cell sample |
| Normal naive CD8 T cells derived from peripheral blood mononuclear cells (PBMCs) of healthy Thai individuals. FACS-sorted CD3+, CD8+, CD45RA+, and CCR7+ naive CD8 T subtype cells were used for analysis. |
hepatocyte (ESC) / HepaRG
Relative Expression (log2-ratio):3.8424768Number of Samples:8 / 12
| Experimental | hepatocyte (ESC) |
| Hepatocyte-like cells differentiated from embryonic stem cells (ESC) | |
| Control | HepaRG |
| Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code: |
tetracycline study 7 (2000uM) / vehicle (DMSO) treated HepG2 sample
Relative Expression (log2-ratio):-3.611557Number of Samples:3 / 21
| Experimental | tetracycline study 7 (2000uM) |
| HepG2 cells treated with compound: tetracycline (2000uM; CAS no.:60-54-8) for 24 hours. Tetracycline is hepatotoxic and may cause steatosis. HepG2 cells were treated with the IC20 concentration measured after 24 hours. ATC code:, , , , , | |
| Control | vehicle (DMSO) treated HepG2 sample |
| HepG2 cells treated with DMSO (0.5% v/v) as solvent control for 24 hours. |
hCMV study 1 (CD69+) / uninfected CD4 T-LGL sample (diseased)
Relative Expression (log2-ratio):-3.418437Number of Samples:4 / 3
| Experimental | hCMV study 1 (CD69+) |
| CD69+ human cytomegalovirus (hCMV)-stimulated monoclonal CD4+ T-large granular lymphocytes (T-LGL) from peripheral blood of patients with monoclonal T-cell receptor (TCR)-alphabeta(+)/CD4(+) T-large granular lymphocyte (LGL) lymphocytosis. | |
| Control | uninfected CD4 T-LGL sample (diseased) |
| Unstimulated monoclonal CD4+ T-large granular lymphocytes (T-LGL) from peripheral blood of patients with monoclonal T-cell receptor (TCR)-alphabeta(+)/CD4(+) T-large granular lymphocyte (LGL) lymphocytosis. |
HIV-associated neurocognitive disorder study 3 (HIVE) / HIV-associated neurocognitive disorder study 1 (HIVE)
Relative Expression (log2-ratio):3.3557863Number of Samples:2 / 6
| Experimental | HIV-associated neurocognitive disorder study 3 (HIVE) |
| Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with HIV encephalitis (HIVE). HIVE was limited to the basal ganglia. The patients did not receive any antiretroviral therapy (ART). | |
| Control | HIV-associated neurocognitive disorder study 1 (HIVE) |
| Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with HIV encephalitis (HIVE). The patients did not receive any antiretroviral therapy (ART). |
HIV-associated neurocognitive disorder study 2 (HIVE) / HIV-associated neurocognitive disorder study 1 (HIVE)
Relative Expression (log2-ratio):3.353754Number of Samples:2 / 6
| Experimental | HIV-associated neurocognitive disorder study 2 (HIVE) |
| Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with HIV encephalitis (HIVE). The patients received an antiretroviral therapy (ART). | |
| Control | HIV-associated neurocognitive disorder study 1 (HIVE) |
| Postmortem brain samples of the centrum semiovale (deep white matter) at the coronal level of the genu of the corpus callosum from patients with HIV encephalitis (HIVE). The patients did not receive any antiretroviral therapy (ART). |
nephroblastoma study 2 / normal kidney tissue (adult)
Relative Expression (log2-ratio):3.3286228Number of Samples:4 / 3
| Experimental | nephroblastoma study 2 |
| Tumor tissue samples from the kidney of patients with Wilms’ tumor. | |
| Control | normal kidney tissue (adult) |
| Normal adult kidney tissue samples. |