Organism: Homo sapiens
Gene: 39612_at
Selected probe(set): 213776_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39612_at (213776_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):2.5807018
Number of Samples:3 / 3

Experimental	wound healing study 2 (ex vivo; AG1478)
	Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing AG1478 for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 10 micromolar AG1478 (dissolved in DMSO). The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin. AG1478 is EGFR kinase inhibitor. ATC code:---
Control	normal skin tissue (ex vivo)
	Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.

Relative Expression (log2-ratio):2.3079872
Number of Samples:3 / 3

Experimental	wound healing study 2 (ex vivo; DMSO)
	Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing DMSO for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 1:1000 fold dilution of DMSO. The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin.
Control	normal skin tissue (ex vivo)
	Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.

Relative Expression (log2-ratio):2.0620518
Number of Samples:3 / 3

Experimental	glioma study 17 (astrocytoma; A2B5+)
	Oligodendrocyte progenitor cells (OPC) isolated from low grade astrocytoma (grade II). OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen. Patients were 36 ± 7 years old.
Control	non-tumor oligodendrocyte progenitor cell sample (cortex)
	Oligodendrocyte progenitor cells (OPC) isolated from cortical tissue, which was obtained from patients with epilepsy, but without any manifested brain cancer. OPC were isolated using magnetic-activated cell sorting (MACS) with antibodies against A2B5 antigen.

Relative Expression (log2-ratio):-2.002143
Number of Samples:3 / 2

Experimental	glioma study 16 (secondary glioblastoma)
	Secondary glioma tissues obtained from the operating room. Tumors were diagnosed and graded according to the current WHO classification (grade IV).
Control	normal brain tissue
	Normal brain tissue sample from healthy donors.

Relative Expression (log2-ratio):-1.974266
Number of Samples:12 / 9

Experimental	glioma study 5
	Primary tumor tissue sample from the supratentorial brain of pediatric patients with glioblastoma multiformae.
Control	non-tumor brain tissue
	Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

Relative Expression (log2-ratio):1.9605827
Number of Samples:3 / 4

Experimental	R547 study 3 (24h)
	Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 24 hours at an IC90 concentration of IC90 = 1.7 μmol/L. ATC code:---
Control	vehicle (DMSO) treated DU145 cell sample
	Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 24 hours.

Relative Expression (log2-ratio):-1.8955774
Number of Samples:20 / 9

Experimental	atypical teratoid/rhabdoid tumor study 1
	Primary tumor tissue sample from the brain of pediatric patients with atypical teratoid/rhabdoid tumor (AT/RT).
Control	non-tumor brain tissue
	Histologically normal brain tissue at rapid autopsy from patients who died from atypical teratoid/rhabdoid tumor.

Relative Expression (log2-ratio):-1.8301563
Number of Samples:46 / 12

Experimental	brain tumor study 1 (ependymoma)
	Primary tumor tissue sample from the brain of patients with ependymoma.
Control	normal brain tissue
	Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

Relative Expression (log2-ratio):-1.825346
Number of Samples:34 / 12

Experimental	brain tumor study 1 (glioblastoma)
	Primary tumor tissue sample from the brain of patients with glioblastoma multiformae.
Control	normal brain tissue
	Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

Relative Expression (log2-ratio):1.7662945
Number of Samples:2 / 2

Experimental	theophylline study 5 (10000uM)
	Hepatocytes treated with compound: theophylline (10000uM; CHEMBL190) for 24 hours. ATC code:
Control	vehicle (medium) treated hepatocyte sample
	Hepatocytes treated with vehicle (medium) for 24 hours.