TOP TEN perturbations for 39626_s_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39626_s_at
Selected probe(set): 210265_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39626_s_at (210265_x_at) across 6674 perturbations tested by GENEVESTIGATOR:
stem cell differentiation study 59 (iDRG; 15d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-7.4937057Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 15d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 12d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-7.1662645Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 12d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (8d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-7.139786Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (8d) |
| WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 9d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-7.085825Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 9d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 1 day. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-6.3665543Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) / hepatocyte-like cell differentiation study 1 (5d)
Relative Expression (log2-ratio):-4.8942633Number of Samples:3 / 3
| Experimental | hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09) and transfected with shRNA targeting HNF4A. ES cells were grown in human ES cell media DMEM/F12 and differentiated to mature hepatocytes for 20 days. Moreover hESc was stable transfected with lentivirus expressing an shRNA that efficiently depletes HNF4A. | |
| Control | hepatocyte-like cell differentiation study 1 (5d) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days. |
hepatocyte-like cell differentiation study 1 (15d) / hepatocyte-like cell differentiation study 1 (5d)
Relative Expression (log2-ratio):-4.8608856Number of Samples:3 / 3
| Experimental | hepatocyte-like cell differentiation study 1 (15d) |
| Hepatocyte-like cells differentiated from human embryonic stem cells (ES, WA09), 15 days after the onset of differentiation. This stage is approximately corresponding to immature hepatocytes. Human H9 (WA09) ES cells were routinely cultured under low oxygen conditions (4% O2/5% CO2) in human ES cell media (DMEM/F12 medium supplemented with 20% knockout serum replacement, non essential amino acids, glutamine, penicillin/streptomycin and bFGF (4ng/ml) on Matrigel coated plates using MEF-conditioned human ES cell media. Differentiation was initiated by culture for 5 days with 100ng/ml Activin A in RPMI/B27 medium under ambient oxygen/5%CO2 followed by 5 days with 20ng/ml BMP4 /10ng/ml FGF-2 in RPMI/B27 under 4%O2/5%CO2, then 5 days with 20ng/ml HGF in RPMI/B27 supplement under 4%O2/5%CO2. | |
| Control | hepatocyte-like cell differentiation study 1 (5d) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days. |
stem cell differentiation study 41 (hES-T3 EB) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-3.3685617Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (hES-T3 EB) |
| Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
stem cell differentiation study 41 (T3pi) / stem cell differentiation study 41 (hES-T3 EB)
Relative Expression (log2-ratio):-2.9979925Number of Samples:2 / 2
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | stem cell differentiation study 41 (hES-T3 EB) |
| Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype. |
expO ovary cancer study 1 (endometrioid carcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-2.989995Number of Samples:3 / 2
| Experimental | expO ovary cancer study 1 (endometrioid carcinoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary endometrioid carcinoma of the ovary. | |
| Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
Organism: Homo sapiens
Gene: 39626_s_at
Selected probe(set): 214532_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39626_s_at (214532_x_at) across 6674 perturbations tested by GENEVESTIGATOR:
stem cell differentiation study 59 (iDRG; 9d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.758148Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 9d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 1 day. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 15d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.7492867Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 15d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (8d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.4929657Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (8d) |
| WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 12d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.468792Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 12d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-5.144144Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) / hepatocyte-like cell differentiation study 1 (5d)
Relative Expression (log2-ratio):-4.1538258Number of Samples:3 / 3
| Experimental | hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09) and transfected with shRNA targeting HNF4A. ES cells were grown in human ES cell media DMEM/F12 and differentiated to mature hepatocytes for 20 days. Moreover hESc was stable transfected with lentivirus expressing an shRNA that efficiently depletes HNF4A. | |
| Control | hepatocyte-like cell differentiation study 1 (5d) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days. |
hepatocyte-like cell differentiation study 1 (15d) / hepatocyte-like cell differentiation study 1 (5d)
Relative Expression (log2-ratio):-4.089551Number of Samples:3 / 3
| Experimental | hepatocyte-like cell differentiation study 1 (15d) |
| Hepatocyte-like cells differentiated from human embryonic stem cells (ES, WA09), 15 days after the onset of differentiation. This stage is approximately corresponding to immature hepatocytes. Human H9 (WA09) ES cells were routinely cultured under low oxygen conditions (4% O2/5% CO2) in human ES cell media (DMEM/F12 medium supplemented with 20% knockout serum replacement, non essential amino acids, glutamine, penicillin/streptomycin and bFGF (4ng/ml) on Matrigel coated plates using MEF-conditioned human ES cell media. Differentiation was initiated by culture for 5 days with 100ng/ml Activin A in RPMI/B27 medium under ambient oxygen/5%CO2 followed by 5 days with 20ng/ml BMP4 /10ng/ml FGF-2 in RPMI/B27 under 4%O2/5%CO2, then 5 days with 20ng/ml HGF in RPMI/B27 supplement under 4%O2/5%CO2. | |
| Control | hepatocyte-like cell differentiation study 1 (5d) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days. |
expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-2.9317932Number of Samples:2 / 2
| Experimental | expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary serous surface papillary carcinoma of the ovary. | |
| Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-2.8689985Number of Samples:2 / 2
| Experimental | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. | |
| Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
stem cell differentiation study 41 (T3pi) / stem cell differentiation study 41 (hES-T3 EB)
Relative Expression (log2-ratio):-2.8050556Number of Samples:2 / 2
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | stem cell differentiation study 41 (hES-T3 EB) |
| Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype. |
Organism: Homo sapiens
Gene: 39626_s_at
Selected probe(set): 208286_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39626_s_at (208286_x_at) across 6674 perturbations tested by GENEVESTIGATOR:
stem cell differentiation study 59 (iDRG; 9d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.874612Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 9d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 1 day. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 15d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.727605Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 15d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 12d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.6163244Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 12d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (8d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.5527306Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (8d) |
| WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-5.7460318Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) / hepatocyte-like cell differentiation study 1 (5d)
Relative Expression (log2-ratio):-4.0318146Number of Samples:3 / 3
| Experimental | hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09) and transfected with shRNA targeting HNF4A. ES cells were grown in human ES cell media DMEM/F12 and differentiated to mature hepatocytes for 20 days. Moreover hESc was stable transfected with lentivirus expressing an shRNA that efficiently depletes HNF4A. | |
| Control | hepatocyte-like cell differentiation study 1 (5d) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days. |
hepatocyte-like cell differentiation study 1 (15d) / hepatocyte-like cell differentiation study 1 (5d)
Relative Expression (log2-ratio):-3.7315254Number of Samples:3 / 3
| Experimental | hepatocyte-like cell differentiation study 1 (15d) |
| Hepatocyte-like cells differentiated from human embryonic stem cells (ES, WA09), 15 days after the onset of differentiation. This stage is approximately corresponding to immature hepatocytes. Human H9 (WA09) ES cells were routinely cultured under low oxygen conditions (4% O2/5% CO2) in human ES cell media (DMEM/F12 medium supplemented with 20% knockout serum replacement, non essential amino acids, glutamine, penicillin/streptomycin and bFGF (4ng/ml) on Matrigel coated plates using MEF-conditioned human ES cell media. Differentiation was initiated by culture for 5 days with 100ng/ml Activin A in RPMI/B27 medium under ambient oxygen/5%CO2 followed by 5 days with 20ng/ml BMP4 /10ng/ml FGF-2 in RPMI/B27 under 4%O2/5%CO2, then 5 days with 20ng/ml HGF in RPMI/B27 supplement under 4%O2/5%CO2. | |
| Control | hepatocyte-like cell differentiation study 1 (5d) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days. |
expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-3.212057Number of Samples:2 / 2
| Experimental | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. | |
| Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
stem cell differentiation study 41 (hES-T3 EB) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-2.9894772Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (hES-T3 EB) |
| Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-2.9701405Number of Samples:2 / 2
| Experimental | expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary serous surface papillary carcinoma of the ovary. | |
| Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
Organism: Homo sapiens
Gene: 39626_s_at
Selected probe(set): 208286_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39626_s_at (208286_x_at) across 6674 perturbations tested by GENEVESTIGATOR:
stem cell differentiation study 59 (iDRG; 9d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.874612Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 9d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 1 day. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 15d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.727605Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 15d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (iDRG; 12d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.6163244Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (iDRG; 12d) |
| Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 59 (8d) / normal embryonic stem cell sample (WA09)
Relative Expression (log2-ratio):-6.5527306Number of Samples:4 / 4
| Experimental | stem cell differentiation study 59 (8d) |
| WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper. | |
| Control | normal embryonic stem cell sample (WA09) |
| Undifferentiated WA09 embryonic stem cell samples. |
stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-5.7460318Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) / hepatocyte-like cell differentiation study 1 (5d)
Relative Expression (log2-ratio):-4.0318146Number of Samples:3 / 3
| Experimental | hepatocyte-like cell differentiation study 1 (20d; HNF4 depl) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09) and transfected with shRNA targeting HNF4A. ES cells were grown in human ES cell media DMEM/F12 and differentiated to mature hepatocytes for 20 days. Moreover hESc was stable transfected with lentivirus expressing an shRNA that efficiently depletes HNF4A. | |
| Control | hepatocyte-like cell differentiation study 1 (5d) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days. |
hepatocyte-like cell differentiation study 1 (15d) / hepatocyte-like cell differentiation study 1 (5d)
Relative Expression (log2-ratio):-3.7315254Number of Samples:3 / 3
| Experimental | hepatocyte-like cell differentiation study 1 (15d) |
| Hepatocyte-like cells differentiated from human embryonic stem cells (ES, WA09), 15 days after the onset of differentiation. This stage is approximately corresponding to immature hepatocytes. Human H9 (WA09) ES cells were routinely cultured under low oxygen conditions (4% O2/5% CO2) in human ES cell media (DMEM/F12 medium supplemented with 20% knockout serum replacement, non essential amino acids, glutamine, penicillin/streptomycin and bFGF (4ng/ml) on Matrigel coated plates using MEF-conditioned human ES cell media. Differentiation was initiated by culture for 5 days with 100ng/ml Activin A in RPMI/B27 medium under ambient oxygen/5%CO2 followed by 5 days with 20ng/ml BMP4 /10ng/ml FGF-2 in RPMI/B27 under 4%O2/5%CO2, then 5 days with 20ng/ml HGF in RPMI/B27 supplement under 4%O2/5%CO2. | |
| Control | hepatocyte-like cell differentiation study 1 (5d) |
| Hepatocyte-like cell differentiated from human pluripotent, embryonic stem cell line (ES, WA09). ES cells were grown in human ES cell media DMEM/F12 and differentiated to definitive endoderm for 5 days. |
expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-3.212057Number of Samples:2 / 2
| Experimental | expO ovary cancer study 1 (granulosa cell tumor, malignant; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary granulosa cell tumor of the ovary. | |
| Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |
stem cell differentiation study 41 (hES-T3 EB) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-2.9894772Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (hES-T3 EB) |
| Sample of embryonic bodies (EB) differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) / expO ovary cancer study 1 (dysgerminoma; metastatic)
Relative Expression (log2-ratio):-2.9701405Number of Samples:2 / 2
| Experimental | expO ovary cancer study 1 (serous surface papillary carcinoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary serous surface papillary carcinoma of the ovary. | |
| Control | expO ovary cancer study 1 (dysgerminoma; metastatic) |
| Metastatic tumor tissue samples obtained from patients with primary dysgerminoma of the ovary. |