TOP TEN perturbations for 39633_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39633_at
Selected probe(set): 206027_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39633_at (206027_at) across 6674 perturbations tested by GENEVESTIGATOR:
PMA study 7 (24h) / vehicle (DMSO) treated HepG2 cell sample
Relative Expression (log2-ratio):5.601942Number of Samples:3 / 7
| Experimental | PMA study 7 (24h) |
| HepG2 cells exposed to 500nM phorbol-12-myristat-13-acetate [(PMA ortetradecanoyl phorbol acetate (TPA)] in DMSO solvent for 24 hours. ATC code:--- | |
| Control | vehicle (DMSO) treated HepG2 cell sample |
| HepG2 cells exposed to DMSO solvent for 24 hours. |
PMA study 7 (12h) / vehicle (DMSO) treated HepG2 cell sample
Relative Expression (log2-ratio):4.455927Number of Samples:2 / 12
| Experimental | PMA study 7 (12h) |
| HepG2 cells exposed to 500nM phorbol-12-myristat-13-acetate [(PMA ortetradecanoyl phorbol acetate (TPA)] in DMSO solvent for 12 hours. ATC code:--- | |
| Control | vehicle (DMSO) treated HepG2 cell sample |
| HepG2 cells exposed to DMSO solvent for 12 hours. |
glioma study 16 (LN-18) / normal astrocyte sample
Relative Expression (log2-ratio):4.443139Number of Samples:2 / 3
| Experimental | glioma study 16 (LN-18) |
| Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2. | |
| Control | normal astrocyte sample |
| Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations. |
CD44s overexpr. study 1 / normal HEK-293 cell sample
Relative Expression (log2-ratio):4.4392414Number of Samples:3 / 3
| Experimental | CD44s overexpr. study 1 |
| Human embryonic kidney cell line HEK-293 transfected with pcDNA3.1(-) vector containing codon-optimized human CD44 sequence for expression. | |
| Control | normal HEK-293 cell sample |
| Untransfected, native human embryonic kidney cell line HEK-293 cell samples. |
alopecia areata study 1 (AU; lesional; validation) / normal skin tissue (validation)
Relative Expression (log2-ratio):-3.4915838Number of Samples:9 / 13
| Experimental | alopecia areata study 1 (AU; lesional; validation) |
| Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata universalis (AU) assigned to validation dataset. | |
| Control | normal skin tissue (validation) |
| Scalp skin punch biopsies obtained from healthy donors assigned to validation dataset. |
PMA study 7 (48h) / vehicle (DMSO) treated HepG2 cell sample
Relative Expression (log2-ratio):3.3473883Number of Samples:3 / 19
| Experimental | PMA study 7 (48h) |
| HepG2 cells exposed to 500nM phorbol-12-myristat-13-acetate [(PMA ortetradecanoyl phorbol acetate (TPA)] in DMSO solvent for 48 hours. ATC code:--- | |
| Control | vehicle (DMSO) treated HepG2 cell sample |
| HepG2 cells exposed to DMSO solvent for 48 hours. |
alopecia areata study 1 (AU; lesional; discovery) / normal skin tissue (discovery)
Relative Expression (log2-ratio):-3.220975Number of Samples:14 / 23
| Experimental | alopecia areata study 1 (AU; lesional; discovery) |
| Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata universalis (AU) assigned to discovery dataset. | |
| Control | normal skin tissue (discovery) |
| Scalp skin punch biopsies obtained from healthy donors assigned to discovery dataset. |
connective/soft tissue cancer study 1 (PDX; connective and soft tissue, synovial sarcoma, spindle cell; primary) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, fibromyxosarcoma; primary)
Relative Expression (log2-ratio):-3.1966171Number of Samples:6 / 5
| Experimental | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, synovial sarcoma, spindle cell; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, synovial sarcoma, spindle cell of the soft tissue (subcutaneously implanted). | |
| Control | connective/soft tissue cancer study 1 (PDX; connective and soft tissue, fibromyxosarcoma; primary) |
| Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, fibromyxosarcoma of the soft tissue (subcutaneously implanted). |
TGF-β study 10 / untreated A549 cell sample
Relative Expression (log2-ratio):-3.0939035Number of Samples:3 / 3
| Experimental | TGF-β study 10 |
| A549 cells were cultured for 2-3 weeks in the presence of 2ng/ml of TGF-β, to induce epithelial-mesenchymal transition (EMT). 24 hours prior analysis cells were re-seeded without TGF-β. | |
| Control | untreated A549 cell sample |
| A549 cells grown in standard media. |
alopecia areata study 1 (AT; lesional; discovery) / normal skin tissue (discovery)
Relative Expression (log2-ratio):-3.0856876Number of Samples:6 / 23
| Experimental | alopecia areata study 1 (AT; lesional; discovery) |
| Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata totalis (AT) assigned to discovery dataset. | |
| Control | normal skin tissue (discovery) |
| Scalp skin punch biopsies obtained from healthy donors assigned to discovery dataset. |