TOP TEN perturbations for 39633_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39633_at
Selected probe(set): 206027_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39633_at (206027_at) across 6674 perturbations tested by GENEVESTIGATOR:

PMA study 7 (24h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):5.601942
Number of Samples:3 / 7
Experimental PMA study 7 (24h)
HepG2 cells exposed to 500nM phorbol-12-myristat-13-acetate [(PMA ortetradecanoyl phorbol acetate (TPA)] in DMSO solvent for 24 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 24 hours.

PMA study 7 (12h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):4.455927
Number of Samples:2 / 12
Experimental PMA study 7 (12h)
HepG2 cells exposed to 500nM phorbol-12-myristat-13-acetate [(PMA ortetradecanoyl phorbol acetate (TPA)] in DMSO solvent for 12 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 12 hours.

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):4.443139
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

CD44s overexpr. study 1 / normal HEK-293 cell sample

Relative Expression (log2-ratio):4.4392414
Number of Samples:3 / 3
Experimental CD44s overexpr. study 1
Human embryonic kidney cell line HEK-293 transfected with pcDNA3.1(-) vector containing codon-optimized human CD44 sequence for expression.
Control normal HEK-293 cell sample
Untransfected, native human embryonic kidney cell line HEK-293 cell samples.

alopecia areata study 1 (AU; lesional; validation) / normal skin tissue (validation)

Relative Expression (log2-ratio):-3.4915838
Number of Samples:9 / 13
Experimental alopecia areata study 1 (AU; lesional; validation)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata universalis (AU) assigned to validation dataset.
Control normal skin tissue (validation)
Scalp skin punch biopsies obtained from healthy donors assigned to validation dataset.

PMA study 7 (48h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):3.3473883
Number of Samples:3 / 19
Experimental PMA study 7 (48h)
HepG2 cells exposed to 500nM phorbol-12-myristat-13-acetate [(PMA ortetradecanoyl phorbol acetate (TPA)] in DMSO solvent for 48 hours. ATC code:---
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 48 hours.

alopecia areata study 1 (AU; lesional; discovery) / normal skin tissue (discovery)

Relative Expression (log2-ratio):-3.220975
Number of Samples:14 / 23
Experimental alopecia areata study 1 (AU; lesional; discovery)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata universalis (AU) assigned to discovery dataset.
Control normal skin tissue (discovery)
Scalp skin punch biopsies obtained from healthy donors assigned to discovery dataset.

connective/soft tissue cancer study 1 (PDX; connective and soft tissue, synovial sarcoma, spindle cell; primary) / connective/soft tissue cancer study 1 (PDX; connective and soft tissue, fibromyxosarcoma; primary)

Relative Expression (log2-ratio):-3.1966171
Number of Samples:6 / 5
Experimental connective/soft tissue cancer study 1 (PDX; connective and soft tissue, synovial sarcoma, spindle cell; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, synovial sarcoma, spindle cell of the soft tissue (subcutaneously implanted).
Control connective/soft tissue cancer study 1 (PDX; connective and soft tissue, fibromyxosarcoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary connective and soft tissue, fibromyxosarcoma of the soft tissue (subcutaneously implanted).

TGF-β study 10 / untreated A549 cell sample

Relative Expression (log2-ratio):-3.0939035
Number of Samples:3 / 3
Experimental TGF-β study 10
A549 cells were cultured for 2-3 weeks in the presence of 2ng/ml of TGF-β, to induce epithelial-mesenchymal transition (EMT). 24 hours prior analysis cells were re-seeded without TGF-β.
Control untreated A549 cell sample
A549 cells grown in standard media.

alopecia areata study 1 (AT; lesional; discovery) / normal skin tissue (discovery)

Relative Expression (log2-ratio):-3.0856876
Number of Samples:6 / 23
Experimental alopecia areata study 1 (AT; lesional; discovery)
Lesional scalp skin punch biopsies obtained from patients who suffered from alopecia areata totalis (AT) assigned to discovery dataset.
Control normal skin tissue (discovery)
Scalp skin punch biopsies obtained from healthy donors assigned to discovery dataset.