TOP TEN perturbations for 39638_at (Homo sapiens)
Organism: Homo sapiens
Gene: 39638_at
Selected probe(set): 205688_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array
Expression of 39638_at (205688_at) across 6674 perturbations tested by GENEVESTIGATOR:
smoking study 82 (3R4F; 22puffs/l; 24h) / smoking study 82 (3R4F; 22puffs/l; 4h)
Relative Expression (log2-ratio):1.6499548Number of Samples:3 / 3
| Experimental | smoking study 82 (3R4F; 22puffs/l; 24h) |
| Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of 3R4F cigarette smoke (medium concentration=22 puffs/l) for 24 hours. AE was generated by bubbling mainstream smoke from 3R4F reference cigarette through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). | |
| Control | smoking study 82 (3R4F; 22puffs/l; 4h) |
| Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of 3R4F cigarette smoke (medium concentration=22 puffs/l) for 4 hours. AE was generated by bubbling mainstream smoke from 3R4F reference cigarette through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). |
smoking study 82 (3R4F; 11puffs/l; 24h) / smoking study 82 (3R4F; 11puffs/l; 4h)
Relative Expression (log2-ratio):1.3848152Number of Samples:3 / 3
| Experimental | smoking study 82 (3R4F; 11puffs/l; 24h) |
| Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of 3R4F cigarette smoke (low concentration=11 puffs/l) for 24 hours. AE was generated by bubbling mainstream smoke from 3R4F reference cigarette through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). | |
| Control | smoking study 82 (3R4F; 11puffs/l; 4h) |
| Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of 3R4F cigarette smoke (low concentration=11 puffs/l) for 4 hours. AE was generated by bubbling mainstream smoke from 3R4F reference cigarette through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). |
smoking study 82 (pMRTP; 33puffs/l; 4h) / smoking study 82 (3R4F; 33puffs/l; 4h)
Relative Expression (log2-ratio):1.303318Number of Samples:3 / 3
| Experimental | smoking study 82 (pMRTP; 33puffs/l; 4h) |
| Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of aerosol from a prototypic modified risk tobacco product (pMRTP; high concentration=33 puffs/l) for 4 hours. AE was generated by bubbling mainstream aerosol from pMRTP through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). pMRTP test sticks were provided by Philip Morris Products. Aerosol of pMRTP was generated by heating (rather than burning) tobacco using a fast-lighting carbon tip. | |
| Control | smoking study 82 (3R4F; 33puffs/l; 4h) |
| Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of 3R4F cigarette smoke (high concentration=33 puffs/l) for 4 hours. AE was generated by bubbling mainstream smoke from 3R4F reference cigarette through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). |
stem cell differentiation study 41 (T3pi) / undifferentiated hES-T3 cell sample
Relative Expression (log2-ratio):-1.2369528Number of Samples:2 / 3
| Experimental | stem cell differentiation study 41 (T3pi) |
| Sample of pancreatic islet-like cell clusters differentiated from human embryonic stem cells T3 with female karyotype. | |
| Control | undifferentiated hES-T3 cell sample |
| Undifferentiated human embryonic stem cells T3. |
smoking study 82 (3R4F; 33puffs/l; 24h) / smoking study 82 (3R4F; 33puffs/l; 4h)
Relative Expression (log2-ratio):1.2086258Number of Samples:3 / 3
| Experimental | smoking study 82 (3R4F; 33puffs/l; 24h) |
| Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of 3R4F cigarette smoke (high concentration=33 puffs/l) for 24 hours. AE was generated by bubbling mainstream smoke from 3R4F reference cigarette through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). | |
| Control | smoking study 82 (3R4F; 33puffs/l; 4h) |
| Normal human bronchial epithelial (NHBE) cells treated with an aqueous extract (AE) of 3R4F cigarette smoke (high concentration=33 puffs/l) for 4 hours. AE was generated by bubbling mainstream smoke from 3R4F reference cigarette through ice-cold PBS using Health Canada smoking regime (puff volume 55 ml, puff duration 2s, puff interval 30s, and 100% blocking of filter ventilation). |
myotonic dystrophy study 4 (skeletal muscle; DM1) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):1.1648264Number of Samples:5 / 3
| Experimental | myotonic dystrophy study 4 (skeletal muscle; DM1) |
| Unspecified skeletal muscle biopsies obtained from patients with myotonic dystrophy type 1 (DM1). | |
| Control | normal skeletal muscle tisuue (fetal) |
| Commercially purchased normal fetal skeletal muscle tissue samples. |
renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue (fetal)
Relative Expression (log2-ratio):1.1638374Number of Samples:4 / 2
| Experimental | renal cell carcinoma study 6 (chromophobe type) |
| Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC). | |
| Control | normal kidney tissue (fetal) |
| Normal fetal kidney tissue samples. |
myotonic dystrophy study 4 (deltoid muscle; DM-like) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):1.1107979Number of Samples:3 / 3
| Experimental | myotonic dystrophy study 4 (deltoid muscle; DM-like) |
| Deltoid muscle biopsies obtained from patients with myotonic-like dystrophy (DMx; DM-like; no DMPK or ZNF9 expansion). | |
| Control | normal skeletal muscle tisuue (fetal) |
| Commercially purchased normal fetal skeletal muscle tissue samples. |
myotonic dystrophy study 4 (deltoid muscle; DM2) / normal skeletal muscle tisuue (fetal)
Relative Expression (log2-ratio):1.1074982Number of Samples:3 / 3
| Experimental | myotonic dystrophy study 4 (deltoid muscle; DM2) |
| Deltoid muscle biopsies obtained from patients with myotonic dystrophy type 2 (DM2). | |
| Control | normal skeletal muscle tisuue (fetal) |
| Commercially purchased normal fetal skeletal muscle tissue samples. |
IgA nephropathy study 8 / control glomerulus tissue
Relative Expression (log2-ratio):-1.1015396Number of Samples:20 / 20
| Experimental | IgA nephropathy study 8 |
| Hand-microdissected glomerular tissue samples derived from kidney biopsies of patients with IgA nephropathy (IgAN). Whole-core patient biopsies were obtained as part of routine renal biopsy procedures. | |
| Control | control glomerulus tissue |
| Hand-microdissected glomerular tissue samples derived from kidney biopsies of healthy living kidney transplant donors. The biopsies were taken after reperfusion in the kidney transplant recipient. |