TOP TEN perturbations for 39642_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39642_at
Selected probe(set): 213712_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39642_at (213712_at) across 6674 perturbations tested by GENEVESTIGATOR:

doxorubicin study 3 / untreated MCF-7 cell sample

Relative Expression (log2-ratio):-4.4440546
Number of Samples:2 / 2
Experimental doxorubicin study 3
MCF7 cells treated with 2uM doxorubicin for 24 hours. ATC code:
Control untreated MCF-7 cell sample
MCF-7 cells untreated.

glioma study 16 (LN-229) / normal astrocyte sample

Relative Expression (log2-ratio):4.263365
Number of Samples:2 / 3
Experimental glioma study 16 (LN-229)
Human glioma cell line LN229 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

OVCAR-8 RIA / OVCAR-8

Relative Expression (log2-ratio):-4.1860723
Number of Samples:3 / 3
Experimental OVCAR-8 RIA
Human metastatic cancer cell line derived from the ascites fluid from a cisplatin-resistant patient with carcinoma of the ovary. Stably transfected with the cAMP-dependent protein kinase (PKA) regulatory subunit gene for RIα. Parental cell line:: OVCAR-8 Cellosaurus code:
Control OVCAR-8
Human metastatic cancer cell line derived from the ascites fluid from a cisplatin-resistant patient with carcinoma of the ovary. Synonyms:NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 Cellosaurus code:

OVCAR-8 RIIB / OVCAR-8

Relative Expression (log2-ratio):-4.0416145
Number of Samples:3 / 3
Experimental OVCAR-8 RIIB
Human metastatic cancer cell line derived from the ascites fluid from a cisplatin-resistant patient with carcinoma of the ovary. Stably transfected with the cAMP-dependent protein kinase (PKA) regulatory subunit gene for RIIβ. Parental cell line:: OVCAR-8 Cellosaurus code:
Control OVCAR-8
Human metastatic cancer cell line derived from the ascites fluid from a cisplatin-resistant patient with carcinoma of the ovary. Synonyms:NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 Cellosaurus code:

glioma study 16 (LN-319) / normal astrocyte sample

Relative Expression (log2-ratio):3.955224
Number of Samples:2 / 3
Experimental glioma study 16 (LN-319)
Human glioma cell line LN319 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37°C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

Merkel cell carcinoma study 3 (metastatic) / normal skin tissue

Relative Expression (log2-ratio):3.7986164
Number of Samples:11 / 64
Experimental Merkel cell carcinoma study 3 (metastatic)
Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control normal skin tissue
Normal skin samples from healthy donors.

rheumatoid arthritis study 69 (TNF; 20h; 1ng/ml) / rheumatoid arthritis study 69 (TNF; IL-17A; baseline)

Relative Expression (log2-ratio):3.670916
Number of Samples:6 / 6
Experimental rheumatoid arthritis study 69 (TNF; 20h; 1ng/ml)
Joint synovial fibroblast samples from patients with rheumatoid arthritis after treatment with 1ng/ml TNF for 20 hours. Synovial fibroblasts were isolated from tissues discarded after synovectomy or joint replacement and isolated from digested synovial tissue and sorted for enriched CD45−, CD31−, CD235a−, Pdpn+ surface proteins. Cells were maintained in DMEM supplemented with 10% FBS, 2 mM L-glutamine, 50 uM 2-mercaptoethanol, antibiotics (penicillin and streptomycin), and essential and nonessential amino acids and used between passages 5 and 8 for treatment.
Control rheumatoid arthritis study 69 (TNF; IL-17A; baseline)
Joint synovial fibroblast samples at baseline from patients with rheumatoid arthritis before treatment with 1ng/ml TNF and/or IL-17 for 20 hours. Synovial fibroblasts were isolated from tissues discarded after synovectomy or joint replacement and prepared from digested synovial tissue and sorted for enriched CD45−, CD31−, CD235a−, Pdpn+ surface proteins. Cells were maintained in DMEM supplemented with 10% FBS, 2 mM L-glutamine, 50 uM 2-mercaptoethanol, antibiotics (penicillin and streptomycin), and essential and nonessential amino acids and used between passages 5 and 8 for treatment.

rheumatoid arthritis study 69 (TNF; 20h; 1ng/ml) / rheumatoid arthritis study 69 (untreated)

Relative Expression (log2-ratio):3.5441341
Number of Samples:6 / 6
Experimental rheumatoid arthritis study 69 (TNF; 20h; 1ng/ml)
Joint synovial fibroblast samples from patients with rheumatoid arthritis after treatment with 1ng/ml TNF for 20 hours. Synovial fibroblasts were isolated from tissues discarded after synovectomy or joint replacement and isolated from digested synovial tissue and sorted for enriched CD45−, CD31−, CD235a−, Pdpn+ surface proteins. Cells were maintained in DMEM supplemented with 10% FBS, 2 mM L-glutamine, 50 uM 2-mercaptoethanol, antibiotics (penicillin and streptomycin), and essential and nonessential amino acids and used between passages 5 and 8 for treatment.
Control rheumatoid arthritis study 69 (untreated)
Joint synovial fibroblast samples from patients with rheumatoid arthritis. Synovial fibroblasts were isolated from tissues discarded after synovectomy or joint replacement and prepared from digested synovial tissue and sorted for enriched CD45−, CD31−, CD235a−, Pdpn+ surface proteins. Cells were maintained in DMEM supplemented with 10% FBS, 2 mM L-glutamine, 50 uM 2-mercaptoethanol, antibiotics (penicillin and streptomycin), and essential and nonessential amino acids and used between passages 5 and 8 for treatment.

ARC study 1 / untreated MCF-7 cell sample

Relative Expression (log2-ratio):-3.3829775
Number of Samples:2 / 2
Experimental ARC study 1
MCF7 cells treated with 2uM ARC (4-amino-6-hydrazino-7-beta-d-ribofuranosyl-7H-pyrrolo-(2, 3-d)-pyrimidine-5-carboxamide, NSC 188491) for 24 hours. ATC code:---
Control untreated MCF-7 cell sample
MCF-7 cells untreated.

Merkel cell carcinoma study 3 (primary) / normal skin tissue

Relative Expression (log2-ratio):3.28967
Number of Samples:19 / 64
Experimental Merkel cell carcinoma study 3 (primary)
Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control normal skin tissue
Normal skin samples from healthy donors.