Organism: Homo sapiens
Gene: 39661_s_at
Selected probe(set): 204717_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39661_s_at (204717_s_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-2.6961164
Number of Samples:3 / 3

Experimental	succinate dehydrogenase B depletion study 1 (siRNA)
	Hep3B cells stably transfected with short hairpin vectors containing an siRNA directed to the subunit B of the succinate dehydrogenase.
Control	control siRNA transfected Hep3B cell sample
	Hep3B cells stably transfected with empty siRNA expression vector (pU6).

Relative Expression (log2-ratio):-2.644248
Number of Samples:2 / 2

Experimental	ARC study 1
	MCF7 cells treated with 2uM ARC (4-amino-6-hydrazino-7-beta-d-ribofuranosyl-7H-pyrrolo-(2, 3-d)-pyrimidine-5-carboxamide, NSC 188491) for 24 hours. ATC code:---
Control	untreated MCF-7 cell sample
	MCF-7 cells untreated.

Relative Expression (log2-ratio):2.4827347
Number of Samples:2 / 2

Experimental	ketoconazole study 6 (15uM)
	Hepatocytes treated with compound: ketoconazole (15uM; CHEMBL75) for 24 hours. ATC code:, ,
Control	vehicle (DMSO) treated hepatocyte sample
	Hepatocytes treated with vehicle (DMSO) for 24 hours.

Relative Expression (log2-ratio):2.4763355
Number of Samples:4 / 4

Experimental	ovarian tumor study 14
	Human pooled cancer samples from the ovary of patients with moderate and poorly differentiated serous carcinoma of the ovary.
Control	normal ovarian surface epithelial cell sample
	Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue from donors with non-cancerous, benign gynecological diseases.

Relative Expression (log2-ratio):2.2647858
Number of Samples:9 / 12

Experimental	Hep-G2
	Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:
Control	HepaRG
	Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

Relative Expression (log2-ratio):2.0748606
Number of Samples:3 / 3

Experimental	gefitinib study 2
	Gefitinib-resistant A431 (A431 GR) cells generated by growing parental cells in the presence of increasing concentrations of gefitinib up to 3 μM. Cells were selected and maintained in gefitinib (3μM). ATC code:
Control	wild type A431 cell sample
	A431 wild type cells.

Relative Expression (log2-ratio):-2.0256805
Number of Samples:2 / 2

Experimental	doxorubicin study 3
	MCF7 cells treated with 2uM doxorubicin for 24 hours. ATC code:
Control	untreated MCF-7 cell sample
	MCF-7 cells untreated.

Relative Expression (log2-ratio):1.9959774
Number of Samples:2 / 5

Experimental	colorectal cancer study 43 (metastase; brain)
	Metastatic tumor tissue obtained from the brain of patients with primary colorectal adenocarcinoma.
Control	colorectal cancer study 43 (metastase; lung)
	Metastatic tumor tissue obtained from the lung of patients with primary colon adenocarcinoma.

Relative Expression (log2-ratio):-1.9622183
Number of Samples:4 / 3

Experimental	tumor supernatant activation study 3
	Memory (CD45RA-) CD4+ T cells isolated from peripheral blood of female healthy donors were incubated for 24 hours in 1:1 mix of tumor supernatant from primary invasive breast ductal carcinoma and X-VIVO 20 medium supplemented with antiCD3/CD28 beads, before harvest for RNA isolation. The tumor supernatant was prepared as followed: fresh surgical specimen was dissociated in X-VIVO 20 medium by GentleMACS dissociator and the resulting suspension was clarified by centrifugation for 15min at 13'000 g. ATC code:---
Control	untreated memory CD4 T-cell sample
	Memory (CD45RA-) CD4+ T-cells were isolated from peripheral blood of healthy female donors and incubated in X-VIVO 20 medium for 24 hours, before harvest for RNA isolation.

Relative Expression (log2-ratio):-1.9576817
Number of Samples:2 / 6

Experimental	dysferlinopathy study 2 (LGMD2B; severe)
	Biopsies of vastus lateralis muscle from male patients with limb-girdle muscular dystrophy 2B (LGMD2B) and severe fibrotic replacement. All subjects showed evidence of a dystrophic process (degeneration/regeneration of muscle fibers) and dysferlin mutation.
Control	normal vastus lateralis tissue
	Biopsies of vastus lateralis muscle from young adult volunteers. Samples were taken as normal controls from baseline samples of exercise experiments.