TOP TEN perturbations for 39710_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39710_at
Selected probe(set): 201310_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39710_at (201310_s_at) across 6674 perturbations tested by GENEVESTIGATOR:

glioma study 16 (LN-18) / normal astrocyte sample

Relative Expression (log2-ratio):-5.4045296
Number of Samples:2 / 3
Experimental glioma study 16 (LN-18)
Human glioma cell line LN018 was cultured in DMEM supplemented with 10% FCS (fetal calf serum) and antibiotics at 37C and 5% CO2.
Control normal astrocyte sample
Normal brain astrocytes. Clonetics normal human astrocytes (NHA) from Cambrex (primary-derived cultures) and cultured according to the manufacturer's recommendations.

azathioprine study 8 (48h) / vehicle (DMSO) treated HepG2 cell sample

Relative Expression (log2-ratio):-5.1322374
Number of Samples:2 / 19
Experimental azathioprine study 8 (48h)
HepG2 cells exposed to 250μM azathioprine in DMSO solvent for 48 hours. ATC code:
Control vehicle (DMSO) treated HepG2 cell sample
HepG2 cells exposed to DMSO solvent for 48 hours.

SKVCR2.0 / SK-OV-3

Relative Expression (log2-ratio):4.9001617
Number of Samples:2 / 2
Experimental SKVCR2.0
Human metastatic cancer cell line derived from the ascites of a patent with adenocarcinoma of the ovary. Vincristine-resistant derivative of the ovarian adenocarcinoma cell line SKOV3 capable of growing in media with 2.0 µg/ml vincristine drug. Parental cell line:: SK-OV-3 Synonyms:SKVCR 2.0; SK VCR 2 Cellosaurus code:
Control SK-OV-3
Human metastatic cancer cell line derived from the ascites of a patient with ovarian serous cystadenocarcinoma. Synonyms:SKOV-3; SK.OV.3; SKOV3; SKO3 Cellosaurus code:

renal cell carcinoma study 6 (chromophobe type) / normal kidney tissue (fetal)

Relative Expression (log2-ratio):-4.884136
Number of Samples:4 / 2
Experimental renal cell carcinoma study 6 (chromophobe type)
Tumor tissue samples from the kidney of patients with chromophobe renal cell carcinoma (cRCC).
Control normal kidney tissue (fetal)
Normal fetal kidney tissue samples.

CML study 1 / B-CLL study 5

Relative Expression (log2-ratio):4.658207
Number of Samples:75 / 441
Experimental CML study 1
Bone marrow samples of patients with chronic myeloid leukemia (CML).
Control B-CLL study 5
Bone marrow samples of patients with B-cell chronic lymphocytic leukemia (B-CLL).

B-CLL study 5 / normal bone marrow sample

Relative Expression (log2-ratio):-4.6551247
Number of Samples:441 / 74
Experimental B-CLL study 5
Bone marrow samples of patients with B-cell chronic lymphocytic leukemia (B-CLL).
Control normal bone marrow sample
Non-leukemic and healthy bone marrow sample.

sepsis-ind. mult. organ failure study 1 / normal vastus lateralis muscle tissue

Relative Expression (log2-ratio):-4.3825073
Number of Samples:12 / 8
Experimental sepsis-ind. mult. organ failure study 1
Muscle biopsies from patients suffering from sepsis-induced multiple organ failure (MOF), treated in the intensive care unit. Biopsies were obtained from the lateral portion of the vastus lateralis muscle, 10-20 cm above the knee, using a Bergstroem biopsy needle after local anesthesia. At the time of the biopsy, all patients were circulatory stable and not suffering from severe sepsis/septic shock. At the time of biopsy all patients were considered to suffer from multiple organ failure.
Control normal vastus lateralis muscle tissue
Muscle biopsies from control patients undergoing elective surgery. Biopsies were obtained from the lateral portion of the vastus lateralis muscle, 10-20 cm above the knee, using a Bergstroem biopsy needle just after sedation.

lung cancer study 1 (PDX; pseudosarcomatous carcinoma; primary) / lung cancer study 1 (PDX; non-small cell carcinoma; primary)

Relative Expression (log2-ratio):4.250082
Number of Samples:4 / 2
Experimental lung cancer study 1 (PDX; pseudosarcomatous carcinoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary pseudosarcomatous carcinoma of the lung (subcutaneously implanted).
Control lung cancer study 1 (PDX; non-small cell carcinoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary non-small cell carcinoma of the lung (subcutaneously implanted).

omeprazole study 6 (600uM) / vehicle (DMSO) treated hepatocyte sample

Relative Expression (log2-ratio):-4.161186
Number of Samples:2 / 2
Experimental omeprazole study 6 (600uM)
Hepatocytes treated with compound: omeprazole (600uM; CHEMBL1503) for 24 hours. ATC code:
Control vehicle (DMSO) treated hepatocyte sample
Hepatocytes treated with vehicle (DMSO) for 24 hours.

oxyphilic adenoma study 1 / normal kidney tissue (fetal)

Relative Expression (log2-ratio):-4.14581
Number of Samples:4 / 2
Experimental oxyphilic adenoma study 1
Tumor tissue samples from the kidney of patients with oxyphilic adenoma (renal oncocytoma).
Control normal kidney tissue (fetal)
Normal fetal kidney tissue samples.