Organism: Homo sapiens
Gene: 39864_at
Selected probe(set): 200810_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39864_at (200810_s_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-2.9387064
Number of Samples:3 / 3

Experimental	wound healing study 2 (ex vivo; AG1478)
	Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing AG1478 for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 10 micromolar AG1478 (dissolved in DMSO). The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin. AG1478 is EGFR kinase inhibitor. ATC code:---
Control	normal skin tissue (ex vivo)
	Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.

Relative Expression (log2-ratio):-2.7927618
Number of Samples:3 / 3

Experimental	wound healing study 2 (ex vivo; DMSO)
	Ex vivo skin samples obtained from healthy donors following reduction surgery of abdomen, and incubated in culture medium containing DMSO for 4 days. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection. Skin was sliced into 1x10 mm slices and incubated in keratinocyte medium for four days with 1:1000 fold dilution of DMSO. The cultivation was performed in serum-free keratinocyte medium supplemented with transferrin, hEGF (0.15 ng/mL), 0.5 mg/mL hydrocortisone, gentamicin, amphotericin B, and epinephrine but without insulin.
Control	normal skin tissue (ex vivo)
	Normal skin samples obtained from healthy donors following reduction surgery of abdomen. To make sure that mainly epidermis was present in the samples, as much dermal tissue as possible was removed by dissection.

Relative Expression (log2-ratio):-2.663827
Number of Samples:3 / 5

Experimental	ovarian tumor study 16
	Human epithelial tumor cell samples from the ovary of patients with papillary serous carcinoma. Samples were derived by laser capture microdissection (LCM).
Control	normal ovarian surface epithelial cell sample
	Human epithelial cell samples from histopathological normal and non-cancerous ovary tissue.

Relative Expression (log2-ratio):-2.5437555
Number of Samples:2 / 2

Experimental	bone cancer study 1 (PDX; chondroblastic osteosarcoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary chondroblastic osteosarcoma of the bone (subcutaneously implanted).
Control	bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)
	Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary myxoid chondrosarcoma of the bone (subcutaneously implanted).

Relative Expression (log2-ratio):-2.473073
Number of Samples:4 / 2

Experimental	Parkinson's disease study 8
	External globus pallidus tissue from patients with Parkinson's disease.
Control	normal external globus pallidus tissue
	Normal external globus pallidus tissue.

Relative Expression (log2-ratio):-2.466586
Number of Samples:3 / 3

Experimental	kidney transplantation study 16 (2 week)
	CD56+ natural killer cell samples derived from kidney transplant patients 2 weeks post-transplantation. Samples were collected 2 week after transplantation and administration of immunosuppressive therapy (day 1-4: methylprednisolone (60 mg); 3 doses: rabbit polyclonal anti-thymocyte globulin (ThymoglobulinH; 6 mg/kg); mycophenolate mofetil (CellCeptH); and tacrolimus (PrografH).
Control	normal natural killer cell (CD56+) sample
	CD56+ natural killer cell samples derived from healthy control subjects.

Relative Expression (log2-ratio):-2.4301662
Number of Samples:2 / 9

Experimental	Parkinson's disease study 3
	Subthalamic nucleus tissue from patients with Parkinson's disease.
Control	normal subthalamic nucleus tissue
	Normal subthalamic nucleus tissue.

Relative Expression (log2-ratio):-2.4099512
Number of Samples:17 / 7

Experimental	breast cancer study 3
	Breast basal tumor samples.
Control	normal mammary gland tissue
	Normal breast tissue samples.

Relative Expression (log2-ratio):-2.3868113
Number of Samples:6 / 6

Experimental	prostate cancer study 1 (meta.)
	Metastatic prostate cancer samples.
Control	benign prostate tissue
	Benign prostate samples.

Relative Expression (log2-ratio):-2.2595139
Number of Samples:6 / 9

Experimental	pediatric septic shock study 3 (school-age; subclass A)
	Whole blood samples obtained from school-age children (≥ 6 years) with septic shock subclass A. The samples were obtained within 24 hours of admission to the pediatric intensive care unit. Three children did not survive. The subclass A was defined based on an empiric, discovery oriented expression filter and unsupervised hierarchical clustering. Patients in subclass A (when all age groups were pooled) had a significantly higher illness severity level (PRISM III score = 20.5, intra-quartile range (IQR) 12.5 – 32.5), a greater degree of organ failure – maximum number of organ failures 3 (IQR 3 - 4), and a higher mortality rate, a significantly higher incidence of documented Gram-positive bacterial infection and were significantly younger compared with other subclasses.
Control	normal blood sample (school-age)
	Whole blood samples from school-age children (≥ 6 years). Children who had a recent febrile illness (within 2 weeks), who recently used anti-inflammatory medications (within 2 weeks) or who had any history of chronic or acute disease associated with inflammation were excluded from the study.