Organism: Homo sapiens
Gene: 39865_at
Selected probe(set): 213474_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39865_at (213474_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-2.7347326
Number of Samples:2 / 2

Experimental	T-cell activation study 1
	CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors were activated with plate bound CD3 (1ug/ml) and soluble CD28 (50ng/ml) for 1 day.
Control	quiescent CD4+ T-cell sample
	Quiescent CD4+ T-cell samples derived from PBMC´s of HIV-seronegative donors.

Relative Expression (log2-ratio):2.5646706
Number of Samples:4 / 4

Experimental	stem cell differentiation study 59 (iDRG; 15d)
	Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper.
Control	normal embryonic stem cell sample (WA09)
	Undifferentiated WA09 embryonic stem cell samples.

Relative Expression (log2-ratio):2.4012356
Number of Samples:4 / 4

Experimental	stem cell differentiation study 59 (iDRG; 12d)
	Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 4 days. Further details are described in the paper.
Control	normal embryonic stem cell sample (WA09)
	Undifferentiated WA09 embryonic stem cell samples.

Relative Expression (log2-ratio):2.3056393
Number of Samples:5 / 6

Experimental	atopic dermatitis study 21 (lesional; whole skin)
	Lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control	normal skin tissue
	Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

Relative Expression (log2-ratio):2.247079
Number of Samples:5 / 6

Experimental	atopic dermatitis study 21 (non-lesional; whole skin)
	Non-lesional full thickness skin samples isolated from patient with moderate-to-severe atopic dermatitis by laser capture microdissection. Patients' cohort characteristics: 3 males and 2 females; age 27-59 years (mean age: 39.4 years); SCORing of Atopic Dermatitis index (SCORAD) ranging from 45-65; total IgE: 14-1821 kU/l; eosinophilic count: 1.4-11.8 %.
Control	normal skin tissue
	Full thickness skin samples isolated from healthy subjects by laser capture microdissection.

Relative Expression (log2-ratio):-2.0750446
Number of Samples:5 / 7

Experimental	E. coli study 2
	Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli.
Control	unstimulated, normal monocyte-derived macrophage sample
	Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated.

Relative Expression (log2-ratio):2.002119
Number of Samples:3 / 4

Experimental	stem cell differentiation study 50 (IRF6 shRNA; ASC; proerythroblast)
	Proerythroblast differentiated from IRF6 (interferon regulatory factor 6) shRNA transduced hematopoietic stem/progenitor cells (CD34+). CD34+ hematopoietic stem/progenitor cells (HSC) were transduced with lentivirus expressing shRNA targeting IRF6 gene with following differentiation to the erythroid lineage. HSCs were obtained from magnetically sorted G-CSF mobilized peripheral blood mononuclear cells of healthy donors. Cells were expanded in StemSpan SFEM medium supplied with Flt-3 ligand (100 ng/ml), SCF (100 ng/ml), IL-3 (20 ng/ml), IL-6 (20 ng/ml) and penicillin/streptomycin. Cells were harvested for total RNA extraction at the proerythroblast stage of differentiation.
Control	stem cell differentiation study 50 (mock shRNA; ASC; proerythroblast)
	Proerythroblast differentiated from control shRNA transduced hematopoietic stem/progenitor cells (CD34+). CD34+ hematopoietic stem/progenitor cells (HSC) were transduced with lentivirus expressing control shRNA with following differentiation to the erythroid lineage. HSCs were obtained from magnetically sorted G-CSF mobilized peripheral blood mononuclear cells of healthy donors. Cells were expanded in StemSpan SFEM medium supplied with Flt-3 ligand (100 ng/ml), SCF (100 ng/ml), IL-3 (20 ng/ml), IL-6 (20 ng/ml) and penicillin/streptomycin. Cells were harvested for total RNA extraction at the proerythroblast stage of differentiation.

Relative Expression (log2-ratio):1.9424238
Number of Samples:4 / 4

Experimental	stem cell differentiation study 59 (iDRG; 15d)
	Immature dorsal root ganglia neurons (iDRGs) obtained by differentiation of WA09 embryonic stem cells. WA09 cells were differentiated for 8 days and subsequently cryopreserved. After thawing, cells were further differentiated for 7 days. Further details are described in the paper.
Control	stem cell differentiation study 59 (8d)
	WA09 embryonic stem cell samples differentiated for 8 days. Further details are described in the paper.

Relative Expression (log2-ratio):-1.9202538
Number of Samples:12 / 16

Experimental	E. coli study 1
	Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours with 2.5 × 105 heat-killed E. coli.
Control	unstimulated, normal monocyte-derived macrophage sample
	Monocyte-derived macrophage samples derived from healthy control subjects cultured for 4 hours unstimulated.

Relative Expression (log2-ratio):1.9091082
Number of Samples:2 / 2

Experimental	sulindac study 5 (3000uM)
	Hepatocytes treated with compound: sulindac (3000uM; CHEMBL15770) for 24 hours. ATC code:
Control	vehicle (medium) treated hepatocyte sample
	Hepatocytes treated with vehicle (medium) for 24 hours.