Organism: Homo sapiens
Gene: 39884_g_at
Selected probe(set): 204405_x_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39884_g_at (204405_x_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-2.8647976
Number of Samples:2 / 4

Experimental	R547 study 1 (24h)
	Human prostate carcinoma metastatic cell line DU145 treated with the CDK inhibitor R547 [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl]-(2, 3-difluoro-6-methoxyphenyl)methanone (Hoffmann-La Roche compound) for 24 hours at a 3xIC90 concentration of 5.1 μmol/L. ATC code:---
Control	vehicle (DMSO) treated DU145 cell sample
	Human prostate carcinoma metastatic cell line DU145 treated with vehicle (DMSO) for 24 hours.

Relative Expression (log2-ratio):2.471346
Number of Samples:24 / 3

Experimental	colorectal cancer study 4 (recurring)
	LCM-tumor tissue samples of patients who received resection after diagnosis of primary colorectal cancer. Patients developed metastatic recurrence during follow-up after surgery.
Control	adjacent colon tissue (recurring)
	Histologically normal colon tissue samples from patients with primary colorectal cancer collected after resection. Tissue was further extracted using laser-capture microdissection (LCM). With metastatic recurrence after resection during follow-up.

Relative Expression (log2-ratio):-2.266183
Number of Samples:2 / 2

Experimental	LPS study 4 (shRNA contr.)
	MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control	mock treated / transduced MONO-MAC-6 cell sample
	MONO-MAC-6 (MM6) cells were transduced with a control shRNA and then mock treated.

Relative Expression (log2-ratio):-2.2227573
Number of Samples:2 / 2

Experimental	zalypsis study 2
	OPM1 multiple myeloma cells treated in vitro with zalypsis (5 nM), a novel marine-derived compound with potent antimyeloma activity. Cells were harvested at the beginning of induction of cell death (15-20% cell death as assessed by Annexin V-FITC staining). ATC code:---
Control	untreated OPM1 cell sample
	OPM1 multiple myeloma cells untreated.

Relative Expression (log2-ratio):2.1741514
Number of Samples:5 / 5

Experimental	colorectal adenoma study 7 (colonic mucosa)
	Colonic mucosa samples obtained by laser capture microdissection (LCM) from patients with colorectal adenoma.
Control	adjacent colon mucosa sample
	Adjacent colon mucosa sample obtained by laser capture microdissection (LCM) from patients with colorectal cancer.

Relative Expression (log2-ratio):-2.1036005
Number of Samples:3 / 3

Experimental	oncolytic herpes simplex virus study 2
	Human malignant peripheral nerve sheath tumor (S462) cells infected with G207, an ICP34.5-deleted oncolytic herpes simplex virus (oHSV) for 6 hours.
Control	mock infected peripheral nerve sheath tumor (S462) cell sample
	Human malignant peripheral nerve sheath tumor (S462) cells mock infected for 6 hours.

Relative Expression (log2-ratio):-2.1030064
Number of Samples:6 / 3

Experimental	engineered skin substitute study 2 (intermediate)
	Human skin substitutes tissue samples collected after 14 and 28 days after transplantation to athymic mice.
Control	engineered skin substitute study 1 (intermediate)
	Human skin substitutes tissue samples collected after 7 days in culture.

Relative Expression (log2-ratio):2.0115652
Number of Samples:76 / 18

Experimental	colorectal cancer study 4 (non-recurring)
	LCM-tumor tissue samples of patients who received resection after diagnosis of primary colorectal cancer. Patients did not develop metastatic recurrence during follow-up after surgery.
Control	adjacent colon tissue (non-recurring)
	Histologically normal colon tissue samples from patients with primary colorectal cancer collected after resection. Tissue was further extracted using laser-capture microdissection (LCM). No metastatic recurrence during follow-up.

Relative Expression (log2-ratio):-1.9996777
Number of Samples:2 / 2

Experimental	LPS study 4
	MONO-MAC-6 (MM6) cells were treated with 10 ng/ml lipopolysaccharide (LPS). ATC code:---
Control	mock treated MONO-MAC-6 cell sample
	MONO-MAC-6 (MM6) cells mock treated.

Relative Expression (log2-ratio):-1.972188
Number of Samples:8 / 17

Experimental	pediatric septic shock study 3 (infant; subclass A)
	Whole blood samples obtained from infants (1 month – 1 year) with septic shock subclass A. The samples were obtained within 24 hours of admission to the pediatric intensive care unit. Two children did not survive. The subclass A was defined based on an empiric, discovery oriented expression filter and unsupervised hierarchical clustering. Patients in subclass A (when all age groups were pooled) had a significantly higher illness severity level (PRISM III score = 20.5, intra-quartile range (IQR) 12.5 – 32.5), a greater degree of organ failure – maximum number of organ failures 3 (IQR 3 - 4), and a higher mortality rate, a significantly higher incidence of documented Gram-positive bacterial infection and were significantly younger compared with other subclasses.
Control	normal blood sample (infant)
	Whole blood samples from infants (1 month – 1 year). Children who had a recent febrile illness (within 2 weeks), who recently used anti-inflammatory medications (within 2 weeks) or who had any history of chronic or acute disease associated with inflammation were excluded from the study.