TOP TEN perturbations for 39920_r_at (Homo sapiens)

Organism: Homo sapiens
Gene: 39920_r_at
Selected probe(set): 205575_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39920_r_at (205575_at) across 6674 perturbations tested by GENEVESTIGATOR:

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (medulloblastoma)

Relative Expression (log2-ratio):3.9745636
Number of Samples:15 / 22
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (medulloblastoma)
Primary tumor tissue sample from the brain of patients with medulloblastoma.

brain tumor study 1 (pilocytic astrocytoma) / normal brain tissue

Relative Expression (log2-ratio):3.506628
Number of Samples:15 / 12
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control normal brain tissue
Histologically normal and non-neoplastic tissue sample from different brain anatomical sites of patients with primary brain tumors.

bone cancer study 1 (PDX; chondrosarcoma, NOS; primary) / bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)

Relative Expression (log2-ratio):-2.9737701
Number of Samples:2 / 2
Experimental bone cancer study 1 (PDX; chondrosarcoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary chondrosarcoma, NOS of the bone (subcutaneously implanted).
Control bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary myxoid chondrosarcoma of the bone (subcutaneously implanted).

expO stomach cancer study 1 (gastrointestinal stromal tumor; primary) / expO stomach cancer study 1 (adenocarcinoma, NOS; primary)

Relative Expression (log2-ratio):2.8542147
Number of Samples:2 / 3
Experimental expO stomach cancer study 1 (gastrointestinal stromal tumor; primary)
Primary tumor tissue samples obtained from the stomach of patients with gastrointestinal stromal tumor.
Control expO stomach cancer study 1 (adenocarcinoma, NOS; primary)
Primary tumor tissue samples obtained from the stomach of patients with adenocarcinoma (NOS).

bone cancer study 1 (PDX; osteosarcoma, NOS; primary) / bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)

Relative Expression (log2-ratio):-2.8266792
Number of Samples:2 / 2
Experimental bone cancer study 1 (PDX; osteosarcoma, NOS; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary osteosarcoma, NOS of the bone (subcutaneously implanted).
Control bone cancer study 1 (PDX; myxoid chondrosarcoma; primary)
Patient-derived xenograft (PDX) samples generated in female athymic nude mice from patients with primary myxoid chondrosarcoma of the bone (subcutaneously implanted).

peritoneal tumor study 1 (papillary serous cystadenocarcinoma; primary) / fallopian tube tumor study 1 (papillary serous cystadenocarcinoma; primary)

Relative Expression (log2-ratio):-2.7576447
Number of Samples:28 / 2
Experimental peritoneal tumor study 1 (papillary serous cystadenocarcinoma; primary)
Primary tumor tissue samples obtained from the peritoneum of female patients with papillary serous cystadenocarcinoma.
Control fallopian tube tumor study 1 (papillary serous cystadenocarcinoma; primary)
Primary tumor tissue samples obtained from the fallopian tube of female patients with papillary serous cystadenocarcinoma.

hepatocyte (ESC) / HepaRG

Relative Expression (log2-ratio):-2.6813402
Number of Samples:8 / 12
Experimental hepatocyte (ESC)
Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control HepaRG
Immortalized cancer cell line derived from female patient with hepatocellular carcinoma. Cells can be induced to differentiate into hepatocyte-like cells by exposure to DMSO. Synonyms:Hepa-RG Cellosaurus code:

pancreatic islet study 3 (re-differentiated; PPRF; 8d) / normal pancreatic islet sample

Relative Expression (log2-ratio):-2.666627
Number of Samples:2 / 7
Experimental pancreatic islet study 3 (re-differentiated; PPRF; 8d)
Human pancreatic islets were isolated from a cadaveric donor. The population was 70% pure in mature islets, which was determined by dithizone staining. Islets cells were expanded for 6 weeks and re-differentiated for 8 days according to Pharmaceutical Production Research Facility (PPRF) Protocol. Re-differentiation phase: For induction of expanded cells to differentiate into islet-like cell clusters, the cells were seeded into 60 mm ultra-low attachment dishes in serum-free CMRL-1066 supplemented with 4 mM L-glutamine, 1% BSA, insulin (10 g/ml), transferrin (5.5 g/ml), sodium selenite (6.7ng/ml), and 1% antibiotic antimycotic solution at a density of 6.0 x 10EXP6 cells per dish. The induction medium was further added with islet neogenesis-associated protein (INGAP) peptide at a concentration of 1.0 ug/ml.
Control normal pancreatic islet sample
Pancreatic islets were obtained from seven donors aged between 37 and 70 years and body mass index between 22 and 27. Functional islets were cultured in CMRL 1066 supplemented with 10% FCS, 1% glutamine, 5.6 mM glucose, 1 mM HEPES, 110 U/ml penicillin, and 110 g/ml streptomycin for 7 days or immediately processed after isolation.

fallopian tube tumor study 1 (papillary serous cystadenocarcinoma; metastase) / fallopian tube tumor study 1 (papillary serous cystadenocarcinoma; primary)

Relative Expression (log2-ratio):-2.6544085
Number of Samples:6 / 2
Experimental fallopian tube tumor study 1 (papillary serous cystadenocarcinoma; metastase)
Metastatic tumor tissue samples obtained from different anatomical sites (bone, colon, ovary and peritoneum) of female patients with primary papillary serous cystadenocarcinoma of the fallopian tube.
Control fallopian tube tumor study 1 (papillary serous cystadenocarcinoma; primary)
Primary tumor tissue samples obtained from the fallopian tube of female patients with papillary serous cystadenocarcinoma.

brain tumor study 1 (pilocytic astrocytoma) / brain tumor study 1 (ependymoma)

Relative Expression (log2-ratio):2.6496735
Number of Samples:15 / 46
Experimental brain tumor study 1 (pilocytic astrocytoma)
Primary tumor tissue sample from the brain of patients with pilocytic astrocytoma.
Control brain tumor study 1 (ependymoma)
Primary tumor tissue sample from the brain of patients with ependymoma.