Organism: Homo sapiens
Gene: 39991_at
Selected probe(set): 206193_s_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39991_at (206193_s_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-5.510642
Number of Samples:40 / 4

Experimental	melanoma study 34 (metastatic)
	Metastatic tumor tissue sample obtained from the patients with metastatic malignant melanoma of the skin. Metastatic samples composed of 22 macroscopic lymph node metastases, 16 subcutaneous metastases and 2 solid organ metastases (adrenal and brain).
Control	normal skin tissue
	Normal skin tissue.

Relative Expression (log2-ratio):-5.477042
Number of Samples:2 / 2

Experimental	keratinocyte differentiation study 2 (KLF4 siRNA)
	KLF4 (Kruppel-like factor 4) depleted primary neonatal keratinocytes differentiated with 1.2 mM calcium for 3 days. Keratinocytes obtained from freshly isolated foreskin were grown in keratinocyte-SFM medium supplemented with epidermal growth factor and bovine pituitary extract. KLF4 depletion was done using siRNAs: KLF4i(A): CCGAGGAGTTCAACGATCT; KLF4i(B): TGACCAGGCACTACCGTAA. Differentiation was induced at 100% confluency.
Control	keratinocyte differentiation study 2
	Primary neonatal keratinocytes differentiated with 1.2 mM calcium for 3 days. Keratinocytes obtained from freshly isolated foreskin were grown in keratinocyte-SFM medium supplemented with epidermal growth factor and bovine pituitary extract. Differentiation was induced at 100% confluency.

Relative Expression (log2-ratio):-5.2138615
Number of Samples:8 / 25

Experimental	psoriasis study 11 (lesional; brodalumab; 15d; 700mg)
	Lesional skin punch biopsies derived from patients with moderate to severe plaque psoriasis at day 15 (week 2) after treatment with a single dose (700 mg i.v.) of brodalumab. ATC code:
Control	psoriasis study 11 (lesional; baseline)
	Lesional skin punch biopsy samples derived from patients with moderate to severe plaque psoriasis before treatment.

Relative Expression (log2-ratio):-5.108227
Number of Samples:11 / 64

Experimental	Merkel cell carcinoma study 3 (metastatic)
	Metastatic tumor tissue from different metastatic sites (skin, lymph node, parotid gland) of patients with Merkel cell carcinoma of the skin.
Control	normal skin tissue
	Normal skin samples from healthy donors.

Relative Expression (log2-ratio):-4.877351
Number of Samples:19 / 64

Experimental	Merkel cell carcinoma study 3 (primary)
	Primary tumor tissue from the skin of patients with Merkel cell carcinoma.
Control	normal skin tissue
	Normal skin samples from healthy donors.

Relative Expression (log2-ratio):-4.8233337
Number of Samples:40 / 2

Experimental	melanoma study 34 (metastatic)
	Metastatic tumor tissue sample obtained from the patients with metastatic malignant melanoma of the skin. Metastatic samples composed of 22 macroscopic lymph node metastases, 16 subcutaneous metastases and 2 solid organ metastases (adrenal and brain).
Control	melanoma study 34 (in situ)
	Tumor tissue from the skin of patients with melanoma in situ.

Relative Expression (log2-ratio):-4.346346
Number of Samples:8 / 5

Experimental	psoriasis study 11 (lesional; brodalumab; 15d; 700mg)
	Lesional skin punch biopsies derived from patients with moderate to severe plaque psoriasis at day 15 (week 2) after treatment with a single dose (700 mg i.v.) of brodalumab. ATC code:
Control	psoriasis study 11 (lesional; placebo; 15d)
	Lesional skin punch biopsies derived from patients with moderate to severe plaque psoriasis at day 15 (week 2) after treatment with placebo.

Relative Expression (log2-ratio):-4.202609
Number of Samples:2 / 64

Experimental	basal cell carcinoma study 2
	Primary tumor tissue from the skin of patients with basal cell carcinoma (BCC).
Control	normal skin tissue
	Normal skin samples from healthy donors.

Relative Expression (log2-ratio):-4.055523
Number of Samples:2 / 2

Experimental	RAF1 overexpr. study 1 (retrovirus)
	MCF-7 cell line stably transfected with retrovirus containing cDNA for RAF1. The following retroviral construct was used: pLNCRaf-1 contains human Raf-1 cDNA encoding an amino terminally truncated form of Raf-1 that is constitutively active, which is inserted into retroviral vector pLNCX encoding neomycin resistance gene (NeoR). MCF7 cells were maintained in EMEM supplemented with 10% FBS and 20ug/ml insulin.
Control	control virus infected MCF7 cell sample
	MCF7 cell line transfected with pZipneo retrovirus, which is an empty retroviral vector encoding neomycine resistance gene (NeoR). MCF7 cells were maintained in EMEM supplemented with 10% FBS and 20ug/ml insulin.

Relative Expression (log2-ratio):-3.6912003
Number of Samples:8 / 25

Experimental	psoriasis study 11 (lesional; brodalumab; 43d; 700mg)
	Lesional skin punch biopsies derived from patients with moderate to severe plaque psoriasis at day 43 (week 6) after treatment with a single dose (700 mg i.v.) of brodalumab. ATC code:
Control	psoriasis study 11 (lesional; baseline)
	Lesional skin punch biopsy samples derived from patients with moderate to severe plaque psoriasis before treatment.