Organism: Homo sapiens
Gene: 39999_at
Selected probe(set): 205467_at
Platform: Affymetrix Human Genome U133 Plus 2.0 Array

Expression of 39999_at (205467_at) across 6674 perturbations tested by GENEVESTIGATOR:

Relative Expression (log2-ratio):-2.5380125
Number of Samples:4 / 4

Experimental	OPM-1
	Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-resistant. Synonyms:OPM1 Cellosaurus code:
Control	MM1.S
	Human primary cancer cell line derived from the peripheral blood of a patient with multiple myeloma. Dexamethasone-sensitive. Parental cell line:: MM.1 Synonyms:MM.1S; MM1-S; MM-1S; MM1S Cellosaurus code:

Relative Expression (log2-ratio):2.4942875
Number of Samples:3 / 17

Experimental	polyinosinic-polycytidylic acid study 1 (10ug/ml)
	Bronchial epithelial cells (NHBE) treated with polyinosinic-polycytidylic acid (Poly(I:C); 10ug/ml; vendor: InvivoGen / catalog number: tlrl-pic / catalog name: Poly(I:C) High Molecular Weight [31852-29-6]) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial). ATC code:
Control	vehicle (DME) treated bronchial epithelial cell sample
	Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).

Relative Expression (log2-ratio):2.4186316
Number of Samples:2 / 17

Experimental	IFN-g study 3
	Bronchial epithelial cells (NHBE) treated with 100 ng/ml recombinant human interferon gamma (IFN-g; vendor: PeproTech / catalog number: 300-02 / catalog name: IFN-γ) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).
Control	vehicle (DME) treated bronchial epithelial cell sample
	Bronchial epithelial cells (NHBE) treated with vehicle (DME) for 6 hours. For treatment primary cells were seeded at a density of 50'000 cells/well in pre-coated rat tail collagen type I 96-well plates for 24 hours followed by 4 hours starvation. NHBE cells were isolated from different Caucasian, healthy and non-smoker donors from the airway located above the bifurcation of the lungs (tracheal/bronchial).

Relative Expression (log2-ratio):-2.2201853
Number of Samples:4 / 4

Experimental	B-CLL study 11 (rolipram)
	Peripheral blood mononuclear cells (PBMCs) obtained from chronic lymphocytic leukemia (CLL) patients and in vitro treated with rolipram (20 uM, cyclic nucleotide phosphodiesterase (PDE4) inhibitor) for 4 hours. PBMCs’ samples contained 90% CD19+ CD5+ B lineage CLL cells (B-CLL). Inclusion criteria: untreated CLL patients or at least 1 month after chemotherapy. Exclusion criteria: patients with active infections or other serious medical conditions or with white blood cell (WBC) counts of 15,000/l. ATC code:---
Control	rolipram study 4 (normal B-cell; 20uM)
	MACS purified resting B-cells from healthy donor peripheral blood treated with rolipram (20 uM, cyclic nucleotide phosphodiesterase (PDE4) inhibitor) for 4 hours. ATC code:---

Relative Expression (log2-ratio):2.1930265
Number of Samples:2 / 2

Experimental	B. burgdorferi study 1 (IFN-g)
	Human umbilical vein endothelial cells (HUVEC) were stimulated with both Interferon-gamma (IFN-g) and Borrelia burgdorferi.
Control	unstimulated HUVEC sample
	Unstimulated human umbilical vein endothelial cells.

Relative Expression (log2-ratio):-2.0142412
Number of Samples:3 / 3

Experimental	colorectal cancer study 9 (metastatic progression)
	LCM-tumor tissue samples of patients who received resection after diagnosis of primary colorectal cancer with metastatic progression.
Control	adjacent colon tissue (metastatic progression)
	Histologically normal colon tissue samples from patients with primary colorectal cancer and metastatic progression collected after resection. Tissue was further extracted using laser-capture microdissection (LCM).

Relative Expression (log2-ratio):1.9912672
Number of Samples:3 / 3

Experimental	ulcerative colitis study 11
	Colon biopsies derived from patients with ulcerative colitis.
Control	colorectal cancer study 13 (tvvad)
	Colon biopsies derived from patients with low grade tubulovillous/villous adenoma.

Relative Expression (log2-ratio):-1.9774466
Number of Samples:3 / 3

Experimental	TGF-β study 11
	HCC827 cells were cultured for 3-5 weeks in the presence of 2ng/ml of TGF-β, to induce epithelial-mesenchymal transition (EMT). 24 hours prior analysis cells were re-seeded without TGF-β.
Control	untreated HCC827 cell sample
	HCC827 cells grown in standard media.

Relative Expression (log2-ratio):-1.9415989
Number of Samples:8 / 9

Experimental	hepatocyte (ESC)
	Hepatocyte-like cells differentiated from embryonic stem cells (ESC)
Control	Hep-G2
	Human primary cancer cell line derived from the liver of a patient with hepatocellular carcinoma. Synonyms:HEP-G2; Hep G2; HEP G2; HepG2; HEPG2 Cellosaurus code:

Relative Expression (log2-ratio):1.9337835
Number of Samples:4 / 3

Experimental	Crohn's disease study 10
	Colon biopsies derived from patients with Crohn's disease.
Control	colorectal cancer study 13 (tvvad)
	Colon biopsies derived from patients with low grade tubulovillous/villous adenoma.